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AB182941

Anti-ITGA7 antibody

4

(1 Review)

|

(5 Publications)

Rabbit Polyclonal ITGA7 antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human ITGA7 aa 1100-1150.

View Alternative Names

UNQ406/PRO768, ITGA7, Integrin alpha-7

1 Images
Western blot - Anti-ITGA7 antibody (AB182941)
  • WB

Supplier Data

Western blot - Anti-ITGA7 antibody (AB182941)

All lanes:

Western blot - Anti-ITGA7 antibody (ab182941) at 0.5 µg/mL

Lane 1:

293T cell lysate

Lane 2:

A431 cell lysate

Lane 3:

HeLa cell lysate

Lane 4:

Jurkat cell lysate

Lane 5:

Raji cell lysate

Predicted band size: 129 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human ITGA7 aa 1100-1150. The exact immunogen used to generate this antibody is proprietary information.

Q13683

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

ITGA7 also known as integrin alpha 7 is a transmembrane protein that plays an important role in cell adhesion and signaling. Weighing approximately 124 kDa ITGA7 is part of the integrin family of proteins functioning as a receptor that binds primarily to extracellular matrix proteins such as laminins. It is expressed largely in skeletal and cardiac muscle tissues but research shows its presence in other tissues like the nervous system.
Biological function summary

ITGA7 interacts with the beta-1 integrin subunit to form a heterodimeric receptor. This combination mediates cell-matrix adhesion promoting cell migration differentiation and survival. ITGA7 is also involved in the stabilization of mature muscle cells and development of muscle fibers. By engaging with specific laminin isoforms ITGA7 influences tissue architecture and function.

Pathways

Researchers recognize that ITGA7 is important in signaling pathways like the PI3K/Akt pathway which affects cell growth and survival. ITGA7 interacts with proteins like focal adhesion kinase (FAK) to transmit signals from the extracellular matrix to the inside of the cell. This communication helps regulate cellular responses and adaptability in dynamic environments.

ITGA7 has connections to muscular dystrophy and certain types of cancer. Mutations or altered expression of ITGA7 can lead to muscular dystrophy where muscle function becomes compromised. In cancer altered ITGA7 expression may affect tumor progression and metastasis with connections to proteins such as dystroglycan. Understanding these relationships is essential for developing targeted therapeutic interventions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as a Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity). Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
See full target information ITGA7
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:12306 PubMed40210748

2025

Molecular typing of gliomas on the basis of integrin family genes and a functional study of ITGA7.

Applications

Unspecified application

Species

Unspecified reactive species

Hongxi Han,Peng Feng,Guoqiang Yuan

Medicine and science in sports and exercise 54:89-97 PubMed34468415

2021

Increases in Integrin-ILK-RICTOR-Akt Proteins, Muscle Mass, and Strength after Eccentric Cycling Training.

Applications

Unspecified application

Species

Unspecified reactive species

Georgios Mavropalias,Yu-Fu Wu,Marni D Boppart,Anthony J Blazevich,Kazunori Nosaka

Journal of cellular and molecular medicine 24:11814-11827 PubMed32885592

2020

Comparative proteomic analysis of osteogenic differentiated human adipose tissue and bone marrow-derived stromal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Mehran Dadras,Caroline May,Johannes Maximilian Wagner,Christoph Wallner,Mustafa Becerikli,Stephanie Dittfeld,Bettina Serschnitzki,Lukas Schilde,Annika Guntermann,Christina Sengstock,Manfred Köller,Dominik Seybold,Jan Geßmann,Thomas Armin Schildhauer,Marcus Lehnhardt,Katrin Marcus,Björn Behr

American journal of cancer research 10:1026-1044 PubMed32266108

2020

LPPR4 promotes peritoneal metastasis via Sp1/integrin α/FAK signaling in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Zang,Chuang Zhang,Ce Li,Yibo Fan,Zhi Li,Kezuo Hou,Xiaofang Che,Yunpeng Liu,Xiujuan Qu

Cancer management and research 11:3237-3251 PubMed31043800

2019

NPTX1 promotes metastasis via integrin/FAK signaling in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Hongfei Yan,Chunlei Zheng,Zhi Li,Bowen Bao,Bowen Yang,Kezuo Hou,Xiujuan Qu,Jiawen Xiao,Xiaofang Che,Yunpeng Liu
View all publications
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