Rabbit Polyclonal ITGB3BP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ITGB3BP.
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- Bioengineered 12:1138-11492021Integrin β3 overexpression contributes to podocyte injury through inhibiting RhoA/YAP signaling pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhuo Li,Zhiwen Lian,Jianchao Ma,Li Zhang,Xingji Lian,Shuangxin Liu,Jianteng Xie,Zhonglin Feng,Ting Lin,Hong Zhang,Xinling LiangPubMed 33818281
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human ITGB3BP. Database link Q13352
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info - | Notes - |
Target data
Function
Transcription coregulator that can have both coactivator and corepressor functions. Isoform 1, but not other isoforms, is involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand-dependent fashion. In contrast, it does not coactivate nuclear receptors for retinoic acid, vitamin D, progesterone receptor, nor glucocorticoid. Acts as a coactivator for estrogen receptor alpha. Acts as a transcriptional corepressor via its interaction with the NFKB1 NF-kappa-B subunit, possibly by interfering with the transactivation domain of NFKB1. Induces apoptosis in breast cancer cells, but not in other cancer cells, via a caspase-2 mediated pathway that involves mitochondrial membrane permeabilization but does not require other caspases. May also act as an inhibitor of cyclin A-associated kinase. Also acts a component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex.
Alternative names
CENPR, NRIF3, ITGB3BP, Centromere protein R, CENP-R, Beta-3-endonexin, Integrin beta-3-binding protein, Nuclear receptor-interacting factor 3
Recommended products
Rabbit Polyclonal ITGB3BP antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ITGB3BP.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human ITGB3BP. Database link Q13352
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The protein ITGB3BP also known as Interferon-induced Transmembrane Protein 1 (IFITM1) plays a role in molecular binding and signal transduction. ITGB3BP weighs approximately 58 kDa. This protein is primarily expressed in various tissues including the brain heart and placenta. Its main function involves interaction with integrin beta-3 a protein involved in the formation of cell-extracellular matrix interactions.
- Biological function summary
ITGB3BP influences cellular processes such as cell adhesion migration and angiogenesis. It forms part of a larger protein complex involving integrins which often associate with intracellular cytoskeletal and signaling components. Through its binding properties ITGB3BP impacts integrin signaling pathways that contribute to tissue formation and repair.
- Pathways
ITGB3BP plays significant roles in the integrin-mediated signaling and PI3K/AKT pathways. Through these pathways ITGB3BP contributes to cellular functions like survival proliferation and motility. The interaction between ITGB3BP and other proteins such as integrins and focal adhesion kinase (FAK) plays a central role in these pathways reinforcing cellular connections to the extracellular matrix.
- Associated diseases and disorders
Mutations or dysregulations in ITGB3BP expression associate with cancer and cardiovascular diseases. In cancer ITGB3BP influences tumor cell invasion and metastasis often working alongside proteins like integrins and matrix metalloproteinases. In cardiovascular diseases the aberrant function of ITGB3BP can affect vascular integrity and heart tissue remodeling potentially linked to altered interactions with integrins.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-ITGB3BP antibody (ab182773)
Gel: 15%+12%+10% SDS-PAGE
All lanes: Western blot - Anti-ITGB3BP antibody (ab182773) at 1/300 dilution
All lanes: 231 cell lysate at 50 µg
SecondaryAll lanes: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution
Predicted band size: 20 kDa
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