AB169271

Anti-ITGB6 antibody

Name: Anti-ITGB6 antibody (ab169271) | Abcam
Brand: Abcam Limited
SKU: AB169271
Price: 535 USD
Availability: InStock

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(1 Publication)

Mouse Polyclonal ITGB6 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Integrin beta-6.

View Alternative Names

Integrin beta-6, ITGB6

1 Images

Unknown

Western blot - Anti-ITGB6 antibody (AB169271)

All lanes:

Western blot - Anti-ITGB6 antibody (ab169271) at 1 µg/mL

Lane 1:

ITGB6 transfected 293T cell lysate at 15 µL

Lane 2:

Non-transfected 293T cell lysate at 15 µL

Predicted band size: 86 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Integrin beta-6.

P18564

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Protein A

Storage buffer

pH: 7.4 Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein ITGB6 also known as Integrin beta-6 is a part of the integrin family which are transmembrane receptors. ITGB6 has a molecular mass of approximately 88 kDa. It functions mechanically by binding to extracellular matrix proteins such as fibronectin vitronectin and tenascin. ITGB6 pairs exclusively with the integrin alpha-V subunit to form the integrin alpha-V beta-6 (αvβ6) heterodimer. Its expression mainly occurs in epithelial cells particularly in the skin lungs and gastrointestinal tract.

Biological function summary

ITGB6 plays important roles in cell adhesion migration and signaling. It is part of the αv integrin complex which is significant in the regulation of transforming growth factor-beta (TGF-β) activation. This activation influences epithelial-mesenchymal transition (EMT) tissue repair and fibrosis. ITGB6 impacts processes such as inflammation and wound healing due to its expression in epithelial tissues thereby contributing to maintaining tissue integrity and function.

Pathways

ITGB6 interacts in the TGF-β signaling and epithelial cell migration pathways. TGF-β activation via ITGB6 plays a critical role in controlling immune responses and cellular proliferation. ITGB6 is interconnected with other integrin family members such as ITGAV (Integrin alpha-V) which collaborates in cellular mechanisms involving cell adhesion and signaling processes. These interactions contribute to cellular responses to extracellular signals that influence pathophysiological processes.

ITGB6 has associations with fibrosis and cancer. In fibrotic diseases ITGB6 facilitates excess activation of TGF-β leading to aberrant tissue remodeling in organs such as the lungs and liver. Regarding cancer ITGB6 influences tumor progression and metastasis particularly in epithelial-derived cancers due to its role in EMT and tissue invasion. ITGB6's interactions with other integrins and ECM proteins contribute to tumorigenesis and fibrotic tissue changes making it a therapeutic target in these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Integrin alpha-V : beta-6 (ITGAV : ITGB6) is a receptor for fibronectin and cytotactin (PubMed : 17158881, PubMed : 17545607). It recognizes the sequence R-G-D in its ligands (PubMed : 17158881, PubMed : 17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed : 17158881, PubMed : 17545607). ITGAV : ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed : 17158881). Integrin alpha-V : beta-6 (ITGAV : ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed : 15184403, PubMed : 22278742, PubMed : 28117447).. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed : 24367260).

See full target information Integrin beta-6

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of orthopaedic research : official publication of the Orthopaedic Research Society 36:272-281 PubMed28574610

2017

Costamere protein expression and tissue composition of rotator cuff muscle after tendon release in sheep.

Applications

Species

Unspecified reactive species

Severin Ruoss,Christoph B Möhl,Mario C Benn,Brigitte von Rechenberg,Karl Wieser,Dominik C Meyer,Christian Gerber,Martin Flück

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ITGB6 antibody

Western blot - Anti-ITGB6 antibody (AB169271)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

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