AB197672

Anti-ITGB6 antibody

Name: Anti-ITGB6 antibody (ab197672) | Abcam
Brand: Abcam Limited
SKU: AB197672
Price: 535 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal ITGB6 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Fusion protein corresponding to Integrin beta-6, fused to Integrin beta-6.

View Alternative Names

Integrin beta-6, ITGB6

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling ITGB6 with ab197672 at 1/10 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Immunohistochemical analysis of paraffin-embedded Human lung cancer tissue labeling ITGB6 with ab197672 at 1/10 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Fusion protein corresponding to Integrin beta-6, fused to Integrin beta-6. The exact immunogen used to generate this antibody is proprietary information.

P18564

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/10 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The protein ITGB6 also known as Integrin beta-6 is a part of the integrin family which are transmembrane receptors. ITGB6 has a molecular mass of approximately 88 kDa. It functions mechanically by binding to extracellular matrix proteins such as fibronectin vitronectin and tenascin. ITGB6 pairs exclusively with the integrin alpha-V subunit to form the integrin alpha-V beta-6 (αvβ6) heterodimer. Its expression mainly occurs in epithelial cells particularly in the skin lungs and gastrointestinal tract.

Biological function summary

ITGB6 plays important roles in cell adhesion migration and signaling. It is part of the αv integrin complex which is significant in the regulation of transforming growth factor-beta (TGF-β) activation. This activation influences epithelial-mesenchymal transition (EMT) tissue repair and fibrosis. ITGB6 impacts processes such as inflammation and wound healing due to its expression in epithelial tissues thereby contributing to maintaining tissue integrity and function.

Pathways

ITGB6 interacts in the TGF-β signaling and epithelial cell migration pathways. TGF-β activation via ITGB6 plays a critical role in controlling immune responses and cellular proliferation. ITGB6 is interconnected with other integrin family members such as ITGAV (Integrin alpha-V) which collaborates in cellular mechanisms involving cell adhesion and signaling processes. These interactions contribute to cellular responses to extracellular signals that influence pathophysiological processes.

ITGB6 has associations with fibrosis and cancer. In fibrotic diseases ITGB6 facilitates excess activation of TGF-β leading to aberrant tissue remodeling in organs such as the lungs and liver. Regarding cancer ITGB6 influences tumor progression and metastasis particularly in epithelial-derived cancers due to its role in EMT and tissue invasion. ITGB6's interactions with other integrins and ECM proteins contribute to tumorigenesis and fibrotic tissue changes making it a therapeutic target in these conditions.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Integrin alpha-V : beta-6 (ITGAV : ITGB6) is a receptor for fibronectin and cytotactin (PubMed : 17158881, PubMed : 17545607). It recognizes the sequence R-G-D in its ligands (PubMed : 17158881, PubMed : 17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed : 17158881, PubMed : 17545607). ITGAV : ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed : 17158881). Integrin alpha-V : beta-6 (ITGAV : ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed : 15184403, PubMed : 22278742, PubMed : 28117447).. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1.. (Microbial infection) Integrin ITGAV : ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed : 24367260).

See full target information Integrin beta-6

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

PloS one 20:e0328263 PubMed40680053

2025

Odontogenesis-associated phosphoprotein (ODAPH) Promotes Ameloblast adhesion and alkaline phosphatase (ALP) expression via LAMC2/ ITGB6/TGF-β1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mingyue Li,Jie Zhang,Shuang Xiao,Xinyang Liu,Shuai Song,Xiaoyuan Ye,Ruonan Bi,Yuguang Gao,Li Zhang

Journal of biochemical and molecular toxicology 38:e23693 PubMed38622980

2024

IGSF10 inhibits the metastasis of lung adenocarcinoma via the Spi-B/Integrin-β1 signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Bo Ling,Guangbin Ye,Chunyan Qin,Xianjiu Liao,Ruirui Yang,Lili Su,Guangzi Qi

Frontiers in oncology 11:759586 PubMed34976806

2021

Systematic Analysis of an Invasion-Related 3-Gene Signature and Its Validation as a Prognostic Model for Pancreatic Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Dafeng Xu,Yu Wang,Yuliang Zhang,Zhehao Liu,Yonghai Chen,Jinfang Zheng

Clinical epigenetics 13:141 PubMed34289901

2021

Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Li-Yuan Feng,Bing-Bing Yan,Yong-Zhi Huang,Li Li

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-ITGB6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB197672)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (4)

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