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Rabbit Polyclonal ITGB6 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Integrin beta-6 aa 100-400.


Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB233519), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB233519), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB233519), expandable thumbnail
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (AB233519), expandable thumbnail
  • Western blot - Anti-ITGB6 antibody (AB233519), expandable thumbnail

Publications

Key facts

Isotype
IgG
Host species
Rabbit
Storage buffer

pH: 7.4
Preservative: 0.011% Proclin 300
Constituents: 55.77% Glycerol (glycerin, glycerine), 44.219% PBS

Form
Liquid
Clonality
Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human Integrin beta-6 aa 100-400. The exact immunogen used to generate this antibody is proprietary information. Database link P18564

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WBIHC-P
Human
Tested
Tested
Mouse
Predicted
Predicted
Rat
Predicted
Predicted
Cow
Predicted
Predicted
Pig
Tested
Expected
Sheep
Predicted
Predicted

Tested
Tested

Species
Pig
Dilution info
0.5-2 µg/mL
Notes

-

Species
Human
Dilution info
0.5-2 µg/mL
Notes

-

Predicted
Predicted

Species
Mouse, Rat, Sheep, Cow
Dilution info
-
Notes

-

Tested
Tested

Species
Human
Dilution info
5-20 µg/mL
Notes

-

Expected
Expected

Species
Pig
Dilution info
Use at an assay dependent concentration.
Notes

-

Predicted
Predicted

Species
Mouse, Rat, Sheep, Cow
Dilution info
-
Notes

-

Associated Products

Select an associated product type

3 products for Alternative Product

Target data

Function

Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (PubMed:17158881, PubMed:17545607). It recognizes the sequence R-G-D in its ligands (PubMed:17158881, PubMed:17545607). Internalization of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion (PubMed:17158881, PubMed:17545607). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:17158881). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:15184403, PubMed:22278742, PubMed:28117447). (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Coxsackievirus A9 and Coxsackievirus B1. (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for Herpes simplex virus-1/HHV-1 (PubMed:24367260).

Alternative names

Recommended products

Rabbit Polyclonal ITGB6 antibody. Suitable for WB, IHC-P and reacts with Pig, Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Integrin beta-6 aa 100-400.

Key facts

Isotype
IgG
Form
Liquid
Clonality
Polyclonal
Immunogen
  • Recombinant Fragment Protein within Human Integrin beta-6 aa 100-400. The exact immunogen used to generate this antibody is proprietary information. Database link P18564
Purification technique
Affinity purification Immunogen
Concentration
Loading...
Purification notes

Antigen-specific affinity chromatography followed by Protein A affinity chromatography.

Storage

Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.
Activity summary

The protein ITGB6 also known as Integrin beta-6 is a part of the integrin family which are transmembrane receptors. ITGB6 has a molecular mass of approximately 88 kDa. It functions mechanically by binding to extracellular matrix proteins such as fibronectin vitronectin and tenascin. ITGB6 pairs exclusively with the integrin alpha-V subunit to form the integrin alpha-V beta-6 (αvβ6) heterodimer. Its expression mainly occurs in epithelial cells particularly in the skin lungs and gastrointestinal tract.

Biological function summary

ITGB6 plays important roles in cell adhesion migration and signaling. It is part of the αv integrin complex which is significant in the regulation of transforming growth factor-beta (TGF-β) activation. This activation influences epithelial-mesenchymal transition (EMT) tissue repair and fibrosis. ITGB6 impacts processes such as inflammation and wound healing due to its expression in epithelial tissues thereby contributing to maintaining tissue integrity and function.

Pathways

ITGB6 interacts in the TGF-β signaling and epithelial cell migration pathways. TGF-β activation via ITGB6 plays a critical role in controlling immune responses and cellular proliferation. ITGB6 is interconnected with other integrin family members such as ITGAV (Integrin alpha-V) which collaborates in cellular mechanisms involving cell adhesion and signaling processes. These interactions contribute to cellular responses to extracellular signals that influence pathophysiological processes.

Associated diseases and disorders

ITGB6 has associations with fibrosis and cancer. In fibrotic diseases ITGB6 facilitates excess activation of TGF-β leading to aberrant tissue remodeling in organs such as the lungs and liver. Regarding cancer ITGB6 influences tumor progression and metastasis particularly in epithelial-derived cancers due to its role in EMT and tissue invasion. ITGB6's interactions with other integrins and ECM proteins contribute to tumorigenesis and fibrotic tissue changes making it a therapeutic target in these conditions.

Product promise

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6 product images

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (ab233519), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (ab233519)

    Formalin-fixed, paraffin-embedded human spleen tissue stained for ITGB6 using ab233519 at 10 μg/ml in immunohistochemical analysis. AEC staining.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (ab233519), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (ab233519)

    Formalin-fixed, paraffin-embedded human pancreas tissue stained for ITGB6 using ab233519 at 10 μg/ml in immunohistochemical analysis. AEC staining.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (ab233519), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (ab233519)

    Formalin-fixed, paraffin-embedded human breast tissue stained for ITGB6 using ab233519 at 10 μg/ml in immunohistochemical analysis. AEC staining.

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (ab233519), expandable thumbnail

    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGB6 antibody (ab233519)

    Formalin-fixed, paraffin-embedded human prostate tissue stained for ITGB6 using ab233519 at 10 μg/ml in immunohistochemical analysis. DAB staining.

  • Western blot - Anti-ITGB6 antibody (ab233519), expandable thumbnail

    Western blot - Anti-ITGB6 antibody (ab233519)

    All lanes: Western blot - Anti-ITGB6 antibody (ab233519) at 2 µg/mL

    All lanes: Pig skin tissue lysate

    Predicted band size: 86 kDa

  • Western blot - Anti-ITGB6 antibody (ab233519), expandable thumbnail

    Western blot - Anti-ITGB6 antibody (ab233519)

    All lanes: Western blot - Anti-ITGB6 antibody (ab233519) at 2 µg/mL

    All lanes: Recombinant human ITGB6 protein

    Predicted band size: 86 kDa

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Product protocols

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