Mouse Polyclonal ITIH1/SHAP antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ITIH1.
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- Stem cells (Dayton, Ohio) 39:280-2952021HC-HA/PTX3 from amniotic membrane reverts senescent limbal niche cells to Pax6+ neural crest progenitors to support limbal epithelial progenitors.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSzu-Yu Chen,Yingting Zhu,Yuan Zhang,David Hsu,Scheffer C G TsengPubMed 33373496
- Scientific reports 7:437362017Inhibition of Proliferation and Epithelial Mesenchymal Transition in Retinal Pigment Epithelial Cells by Heavy Chain-Hyaluronan/Pentraxin 3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHua He,Ajay E Kuriyan,Chen-Wei Su,Megha Mahabole,Yuan Zhang,Ying-Ting Zhu,Harry W Flynn,Jean-Marie Parel,Scheffer C G TsengPubMed 28252047
- Scientific reports 7:421952017Heavy Chain-Hyaluronan/Pentraxin 3 from Amniotic Membrane Suppresses Inflammation and Scarring in Murine Lacrimal Gland and Conjunctiva of Chronic Graft-versus-Host Disease.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYoko Ogawa et. al.PubMed 28165063
- The Journal of biological chemistry 289:13531-422014Constitutive expression of pentraxin 3 (PTX3) protein by human amniotic membrane cells leads to formation of the heavy chain (HC)-hyaluronan (HA)-PTX3 complex.Applications:Unspecified applicationReactive species:Unspecified reactive speciesSuzhen Zhang et. al.PubMed 24652286
- The Journal of biological chemistry 288:25792-8032013Immobilized heavy chain-hyaluronic acid polarizes lipopolysaccharide-activated macrophages toward M2 phenotype.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human ITIH1. Database link P19827
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Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
Associated Products
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Target data
Function
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes. Contains a potential peptide which could stimulate a broad spectrum of phagocytotic cells.
Alternative names
IGHEP1, ITIH1, Inter-alpha-trypsin inhibitor heavy chain H1, ITI heavy chain H1, ITI-HC1, Inter-alpha-inhibitor heavy chain 1, Inter-alpha-trypsin inhibitor complex component III, Serum-derived hyaluronan-associated protein, SHAP
Recommended products
Mouse Polyclonal ITIH1/SHAP antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ITIH1.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 100% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human ITIH1. Database link P19827
- Carrier free
- Yes
- Purification technique
- Affinity purification Protein G
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The target ITIH1 also known as Inter-alpha-trypsin inhibitor heavy chain H1 is a component of the inter-alpha-inhibitor family. ITIH1 has an approximate mass of 100 kDa. This protein is mainly expressed in the liver and secreted into the blood participating in the extracellular matrix. ITIH1 works by stabilizing urinary trypsin inhibitors and playing a role in maintaining structural integrity in tissues especially during inflammation and tissue repair.
- Biological function summary
ITIH1 interacts with other macromolecules to form complexes that modulate the extracellular environment. It is part of a complex that involves proteins like bikunin which is important in the formation of the inter-alpha-inhibitor complex. This complex plays important roles in modulating inflammation and is implicated in various physiological processes like immunological responses.
- Pathways
ITIH1 is integrated into the acute-phase response pathway which responds to inflammation. It cooperates with proteins such as ITIH2 another member of the inter-alpha-trypsin inhibitor family to mediate immune and inflammatory processes. Furthermore ITIH1 participates in the protective mechanisms against pathogenic invasion through the complement pathway.
- Associated diseases and disorders
ITIH1 has associations with conditions such as sepsis and liver cirrhosis. In sepsis ITIH1 levels may be altered influencing the inflammatory response and affecting patient outcomes. The interaction between ITIH1 and proteins involved in these diseases such as tumor necrosis factor-alpha (TNF-alpha) suggests its role as a potential biomarker or therapeutic target in these pathologies.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-ITIH1/SHAP antibody (ab70048)
All lanes: Western blot - Anti-ITIH1/SHAP antibody (ab70048) at 1/500 dilution
Lane 1: ITIH1/SHAP transfected 293T cell lysate at 25 µg
Lane 2: Non-transfected 293T cell lysate at 25 µg
SecondaryAll lanes: Goat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilution
Predicted band size: 101 kDa
Observed band size: 102 kDa
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