Rabbit Polyclonal ITIH3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Inter-alpha-trypsin inhibitor heavy chain H3 aa 100-400.
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Publications
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- Drug design, development and therapy 17:1819-18292023Luteolin Alleviates Liver Fibrosis in Rat Hepatic Stellate Cell HSC-T6: A Proteomic Analysis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBatudeligen,Zhiqiang Han,Hongmei Chen, Narisu,Yanhua Xu, Anda,Gegentaoli HanPubMed 37360572
- The Journal of biological chemistry 289:23465-812014Umbilical cord mesenchymal stem cells suppress host rejection: the role of the glycocalyx.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human Inter-alpha-trypsin inhibitor heavy chain H3 aa 100-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q06033
Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Rabbit | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/500.00000 - 1/3000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rabbit | Dilution info - | Notes - |
Associated Products
Select an associated product type
2 products for Alternative Product
Target data
Function
May act as a carrier of hyaluronan in serum or as a binding protein between hyaluronan and other matrix protein, including those on cell surfaces in tissues to regulate the localization, synthesis and degradation of hyaluronan which are essential to cells undergoing biological processes.
Alternative names
Inter-alpha-trypsin inhibitor heavy chain H3, ITI heavy chain H3, ITI-HC3, Inter-alpha-inhibitor heavy chain 3, Serum-derived hyaluronan-associated protein, SHAP, ITIH3
Recommended products
Rabbit Polyclonal ITIH3 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Inter-alpha-trypsin inhibitor heavy chain H3 aa 100-400.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7
Preservative: 0.01% Thimerosal (merthiolate)
Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human Inter-alpha-trypsin inhibitor heavy chain H3 aa 100-400. The exact immunogen used to generate this antibody is proprietary information. Database link Q06033
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The Inter-Alpha-Trypsin Inhibitor Heavy Chain H3 (ITIH3) is a protein composed of approximately 96 kDa. Researchers commonly refer to it by its abbreviation ITIH3. It is part of the inter-alpha-trypsin inhibitors family which plays roles in multiple biological processes. ITIH3 expresses mainly in the liver but also shows its presence in other tissues and bodily fluids. This protein has a structural component that stabilizes the extracellular matrix by covalently binding with hyaluronan a necessary process for maintaining tissue integrity.
- Biological function summary
ITIH3 functions in the extracellular matrix and as a stabilizer in tissue architecture. It forms a multi-protein complex with other proteins in its family such as ITIH1 and ITIH2. This complex facilitates the inhibition of extracellular proteases and contributes to hyaluronic acid stabilization. The activity of ITIH3 is significant for physiological processes that require a stable extracellular matrix. Protective roles like wound healing and inflammatory response modulation benefit from ITIH3's presence in tissues.
- Pathways
ITIH3 interacts closely with processes involved in cell migration and inflammation. Specifically it takes part in the hyaluronan metabolic pathway alongside other proteins like TSG-6 which also aid in stabilizing the extracellular matrix. ITIH3 influences cellular signaling pathways that affect tissue responses to stress and injury. Understanding how ITIH3 functions within these pathways reveals insights into its roles in tissue repair and cellular integrity.
- Associated diseases and disorders
Researchers linked ITIH3 to neuropsychiatric disorders like schizophrenia and bipolar disorder. Genome-wide association studies have identified connections between ITIH3 and these conditions highlighting its significance in disease biology. Studies revealed links between ITIH3 and other proteins like ITIH4 in schizophrenia-related pathways. ITIH3's involvement in maintaining tissue stability and regulating inflammation might influence its connection to these disorders. This information suggests that ITIH3 potentially serves as a biomarker or therapeutic target in relevant disease contexts.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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1 product image
Western blot - Anti-ITIH3 antibody (ab97758)
7.5% SDS-PAGE.
All lanes: Western blot - Anti-ITIH3 antibody (ab97758) at 1/1000 dilution
All lanes: A431 whole cell lysate at 30 µg
Predicted band size: 100 kDa
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