AB104550

Anti-ITPR2 antibody

Name: Anti-ITPR2 antibody (ab104550) | Abcam
Brand: Abcam Limited
SKU: AB104550
Price: 630 USD
Availability: InStock

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(2 Publications)

Goat Polyclonal ITPR2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Inositol 1,4,5-trisphosphate receptor type 2 aa 1150-1200.

View Alternative Names

IP3 receptor isoform 2, IP3R 2, InsP3R2, Type 2 InsP3 receptor, ITPR2

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

ab104550 at 3.75μg/ml staining ITPR2 in Human kidney by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

ab104550 at 3.75μg/ml staining ITPR2 in Human skin by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

ab104550 at 3.75μg/ml staining ITPR2 in Human heart by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen.

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Inositol 1,4,5-trisphosphate receptor type 2 aa 1150-1200. The exact immunogen used to generate this antibody is proprietary information.

Q14571

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "3.75 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The type 2 inositol 145-trisphosphate receptor (ITPR2) acts as a channel for calcium ions. This receptor is also known as IP3R2 and weighs approximately 313 kDa. It consists of six transmembrane domains. ITPR2 enables the release of calcium from the endoplasmic reticulum into the cytosol. ITPR2 is expressed mostly in the brain heart and testis although its expression can vary in other tissues according to physiological needs.

Biological function summary

ITPR2 regulates intracellular calcium signaling. Calcium ions serve as second messengers in a variety of cellular processes. ITPR2 forms a functional tetrameric complex which increases its functional diversity. This complex plays a role in neuronal communication muscle contraction and various cellular signaling pathways like cell growth.

Pathways

ITPR2 participates actively in the calcium signaling pathway. It closely associates with proteins such as calmodulin that mediate cellular responses. ITPR2 is also central to the phosphoinositide pathway where it links with phospholipase C to initiate downstream effects. These pathways impact diverse physiological functions by modulating intracellular calcium levels.

Abnormal function of ITPR2 links to neurodegenerative diseases such as Alzheimer's disease. It can lead to disrupted calcium homeostasis affecting neuronal viability. ITPR2 also associates with cardiac hypertrophy where calcium imbalance impairs cardiac cell function. Interactions with proteins like amyloid-beta in Alzheimer's contribute to its pathological role. Understanding these interactions could offer targets for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm (PubMed : 25329695). Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity).

See full target information Inositol 1,4,5-trisphosphate receptor type 2

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of molecular and cellular cardiology 179:47-59 PubMed37003353

2023

InsPR-RyR channel crosstalk augments sarcoplasmic reticulum Ca release and arrhythmogenic activity in post-MI pig cardiomyocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Jin,Anna Meletiou,Joshua Chung,Agne Tilunaite,Kateryna Demydenko,Eef Dries,Rosa Doñate Puertas,Matthew Amoni,Ashutosh Tomar,Guillaume Gilbert,Piet Claus,Christian Soeller,Vijay Rajagopal,Karin Sipido,H Llewelyn Roderick

BioMed research international 2014:395781 PubMed24563864

2014

Direct cell-cell contact between mesenchymal stem cells and endothelial progenitor cells induces a pericyte-like phenotype in vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Markus Loibl,Andreas Binder,Marietta Herrmann,Fabian Duttenhoefer,R Geoff Richards,Michael Nerlich,Mauro Alini,Sophie Verrier

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-ITPR2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

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