Rabbit Polyclonal ITPR2 antibody. Suitable for ICC, IHC-Fr and reacts with Human, Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Rat Inositol 1,4,5-trisphosphate receptor type 2 aa 300-350.
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Publications
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- Scientific reports 10:77902020Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPrashant Kumar Jaiswal,Latifa Aljebali,Marie-Hélène Gaumond,Chun-do Oh,Hideyo Yasuda,Pierre MoffattPubMed 32385306
- American journal of respiratory cell and molecular biology 59:684-6942018CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata.Applications:Unspecified applicationReactive species:Unspecified reactive speciesBenjamin Causton,Ana Pardo-Saganta,Jacob Gillis,Katherine Discipio,Tristan Kooistra,Jayaraj Rajagopal,Ramnik J Xavier,Josalyn L Cho,Benjamin D MedoffPubMed 29958012
- The Journal of physiology 593:2649-632015Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells.Applications:Unspecified applicationReactive species:Unspecified reactive speciesNidhi Kapoor et. al.PubMed 25903031
- Journal of molecular and cellular cardiology 52:988-972012Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Rat Inositol 1,4,5-trisphosphate receptor type 2 aa 300-350. The exact immunogen used to generate this antibody is proprietary information. Database link P29995
Reactivity data
Select an application| ICC | WB | IHC-Fr | |
|---|---|---|---|
| Human | Tested | Not recommended | Expected |
| Rat | Expected | Not recommended | Tested |
| Cow | Predicted | Not recommended | Predicted |
ICC
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 2 µg/mL | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow | Dilution info - | Notes - |
WB
Not recommendedNot recommended
| Species | Dilution info | Notes |
|---|---|---|
Species Rat, Human, Cow | Dilution info - | Notes - |
IHC-Fr
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info 1/100 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Cow | Dilution info - | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm (PubMed:25329695). Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity).
Alternative names
IP3 receptor isoform 2, IP3R 2, InsP3R2, Type 2 InsP3 receptor, ITPR2
Recommended products
Rabbit Polyclonal ITPR2 antibody. Suitable for ICC, IHC-Fr and reacts with Human, Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Rat Inositol 1,4,5-trisphosphate receptor type 2 aa 300-350.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.05% Sodium azide
Constituents: 99% PBS, 0.1% BSA- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Rat Inositol 1,4,5-trisphosphate receptor type 2 aa 300-350. The exact immunogen used to generate this antibody is proprietary information. Database link P29995
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
The type 2 inositol 145-trisphosphate receptor (ITPR2) acts as a channel for calcium ions. This receptor is also known as IP3R2 and weighs approximately 313 kDa. It consists of six transmembrane domains. ITPR2 enables the release of calcium from the endoplasmic reticulum into the cytosol. ITPR2 is expressed mostly in the brain heart and testis although its expression can vary in other tissues according to physiological needs.
- Biological function summary
ITPR2 regulates intracellular calcium signaling. Calcium ions serve as second messengers in a variety of cellular processes. ITPR2 forms a functional tetrameric complex which increases its functional diversity. This complex plays a role in neuronal communication muscle contraction and various cellular signaling pathways like cell growth.
- Pathways
ITPR2 participates actively in the calcium signaling pathway. It closely associates with proteins such as calmodulin that mediate cellular responses. ITPR2 is also central to the phosphoinositide pathway where it links with phospholipase C to initiate downstream effects. These pathways impact diverse physiological functions by modulating intracellular calcium levels.
- Associated diseases and disorders
Abnormal function of ITPR2 links to neurodegenerative diseases such as Alzheimer's disease. It can lead to disrupted calcium homeostasis affecting neuronal viability. ITPR2 also associates with cardiac hypertrophy where calcium imbalance impairs cardiac cell function. Interactions with proteins like amyloid-beta in Alzheimer's contribute to its pathological role. Understanding these interactions could offer targets for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Immunocytochemistry - Anti-ITPR2 antibody (ab5805)
4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilised SH-SY5Y (human neuroblastoma cell line from bone marrow) cells labeling ITPR2 using ab5805 at 2 μg/ml in 0.1% BSAfor 3 hours at RT, followed by a Goat Anti-Rabbit (H&L) AlexaFluor® secondary antibody (Green (a)). The nuclear counter stain is DAPI (Blue (b)). F-actin is stained with AlexaFluor® 555-Rhodamine (Red (c)). Panel D shows the merged image. Panel (e) is a secondary antibody only control.
Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (ab5805)
Shows immunolocalization of IP3R-II in rat brain using ab5805.
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