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AB5805

Anti-ITPR2 antibody

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(4 Publications)

Rabbit Polyclonal ITPR2 antibody. Suitable for ICC, IHC-Fr and reacts with Human, Rat samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Rat Inositol 1,4,5-trisphosphate receptor type 2 aa 300-350.

View Alternative Names

IP3 receptor isoform 2, IP3R 2, InsP3R2, Type 2 InsP3 receptor, ITPR2

2 Images
Immunocytochemistry - Anti-ITPR2 antibody (AB5805)
  • ICC

Supplier Data

Immunocytochemistry - Anti-ITPR2 antibody (AB5805)

4% paraformaldehyde-fixed, 0.1% Triton X-100 permeabilised SH-SY5Y (human neuroblastoma cell line from bone marrow) cells labeling ITPR2 using ab5805 at 2 μg/ml in 0.1% BSAfor 3 hours at RT, followed by a Goat Anti-Rabbit (H&L) AlexaFluor® secondary antibody (Green (a)). The nuclear counter stain is DAPI (Blue (b)). F-actin is stained with AlexaFluor® 555-Rhodamine (Red (c)). Panel D shows the merged image. Panel (e) is a secondary antibody only control.

Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (AB5805)
  • IHC-Fr

Unknown

Immunohistochemistry (Frozen sections) - Anti-ITPR2 antibody (AB5805)

Shows immunolocalization of IP3R-II in rat brain using ab5805.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

ICC, IHC-Fr

applications

Immunogen

Synthetic Peptide within Rat Inositol 1,4,5-trisphosphate receptor type 2 aa 300-350. The exact immunogen used to generate this antibody is proprietary information.

P29995

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Alternative Products

Primary Antibodies

AB104550

Anti-ITPR2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITPR2 antibody (AB104550)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB264283

Anti-ITPR3 antibody

Western blot - Anti-ITPR3 antibody (AB264283)

  • 0
  • 0
Primary Antibodies

AB108517

Anti-IP3 receptor antibody [EPR4537]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-IP3 receptor antibody [EPR4537] (AB108517)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB15323

Anti-iNOS antibody

BOND RX™ Validated

Western blot - Anti-iNOS antibody (AB15323)

  • 4
  • 20
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICC" : {"fullname" : "Immunocytochemistry", "shortname":"ICC"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICC-species-checked": "testedAndGuaranteed", "ICC-species-dilution-info": "2 µg/mL", "ICC-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" }, "Rat": { "ICC-species-checked": "guaranteed", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCFr-species-checked": "testedAndGuaranteed", "IHCFr-species-dilution-info": "1/100", "IHCFr-species-notes": "<p></p>" }, "Cow": { "ICC-species-checked": "predicted", "ICC-species-dilution-info": "", "ICC-species-notes": "", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCFr-species-checked": "predicted", "IHCFr-species-dilution-info": "", "IHCFr-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
Preservative: 0.05% Sodium azide Constituents: PBS, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The type 2 inositol 145-trisphosphate receptor (ITPR2) acts as a channel for calcium ions. This receptor is also known as IP3R2 and weighs approximately 313 kDa. It consists of six transmembrane domains. ITPR2 enables the release of calcium from the endoplasmic reticulum into the cytosol. ITPR2 is expressed mostly in the brain heart and testis although its expression can vary in other tissues according to physiological needs.
Biological function summary

ITPR2 regulates intracellular calcium signaling. Calcium ions serve as second messengers in a variety of cellular processes. ITPR2 forms a functional tetrameric complex which increases its functional diversity. This complex plays a role in neuronal communication muscle contraction and various cellular signaling pathways like cell growth.

Pathways

ITPR2 participates actively in the calcium signaling pathway. It closely associates with proteins such as calmodulin that mediate cellular responses. ITPR2 is also central to the phosphoinositide pathway where it links with phospholipase C to initiate downstream effects. These pathways impact diverse physiological functions by modulating intracellular calcium levels.

Abnormal function of ITPR2 links to neurodegenerative diseases such as Alzheimer's disease. It can lead to disrupted calcium homeostasis affecting neuronal viability. ITPR2 also associates with cardiac hypertrophy where calcium imbalance impairs cardiac cell function. Interactions with proteins like amyloid-beta in Alzheimer's contribute to its pathological role. Understanding these interactions could offer targets for therapeutic intervention.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inositol 1,4,5-trisphosphate-gated calcium channel that upon inositol 1,4,5-trisphosphate binding transports calcium from the endoplasmic reticulum lumen to cytoplasm. Exists in two states; a long-lived closed state where the channel is essentially 'parked' with only very rare visits to an open state and that ligands facilitate the transition from the 'parked' state into a 'drive' mode represented by periods of bursting activity (By similarity).
See full target information Inositol 1,4,5-trisphosphate receptor type 2
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 10:7790 PubMed32385306

2020

Biochemical characteristics of the chondrocyte-enriched SNORC protein and its transcriptional regulation by SOX9.

Applications

Unspecified application

Species

Unspecified reactive species

Prashant Kumar Jaiswal,Latifa Aljebali,Marie-Hélène Gaumond,Chun-do Oh,Hideyo Yasuda,Pierre Moffatt

American journal of respiratory cell and molecular biology 59:684-694 PubMed29958012

2018

CARMA3 Mediates Allergic Lung Inflammation in Response to Alternaria alternata.

Applications

Unspecified application

Species

Unspecified reactive species

Benjamin Causton,Ana Pardo-Saganta,Jacob Gillis,Katherine Discipio,Tristan Kooistra,Jayaraj Rajagopal,Ramnik J Xavier,Josalyn L Cho,Benjamin D Medoff

The Journal of physiology 593:2649-63 PubMed25903031

2015

Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells.

Applications

Unspecified application

Species

Unspecified reactive species

Nidhi Kapoor,Andrew Tran,Jeanney Kang,Rui Zhang,Kenneth D Philipson,Joshua I Goldhaber

Journal of molecular and cellular cardiology 52:988-97 PubMed22285480

2012

Arrhythmogenic coupling between the Na+ -Ca2+ exchanger and inositol 1,4,5-triphosphate receptor in rat pulmonary vein cardiomyocytes.

Applications

ICC/IF

Species

Rat

Yosuke Okamoto,Makoto Takano,Takayoshi Ohba,Kyoichi Ono
View all publications
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