Anti-IWS1 antibody - N-terminal
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Rabbit Polyclonal IWS1 antibody. N-terminal. Suitable for IP, WB and reacts with Human, Mouse samples. Immunogen corresponding to Synthetic Peptide within Human IWS1 aa 1-50.
View Alternative Names
IWS1L, IWS1, Protein IWS1 homolog, IWS1-like protein
- IP
Supplier Data
Immunoprecipitation - Anti-IWS1 antibody - N-terminal (AB195309)
Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) from 293T cells prepared using NETN lysis buffer. Antibodies : ab195309 used for IP at 6 μg per reaction. For blotting immunoprecipitated IWS1, ab195309 was used at 0.4 μg/mL.
All lanes:
Immunoprecipitation - Anti-IWS1 antibody - N-terminal (ab195309)
Predicted band size: 92 kDa
true
Exposure time: 30s
- WB
Supplier Data
Western blot - Anti-IWS1 antibody - N-terminal (AB195309)
All lanes:
Western blot - Anti-IWS1 antibody - N-terminal (ab195309) at 0.4 µg/mL
Lane 1:
HeLa cell lysate at 50 µg
Lane 2:
293T cell lysate at 50 µg
Lane 3:
Jurkat cell lysate at 50 µg
Lane 4:
Mouse TCMK-1 cell lysate at 50 µg
Lane 5:
Mouse NIH3T3 cell lysate at 50 µg
Predicted band size: 92 kDa
true
Exposure time: 30s
Reactivity data
Properties and storage information
Form
Purification technique
Storage buffer
Shipped at conditions
Appropriate short-term storage duration
Appropriate short-term storage conditions
Appropriate long-term storage conditions
Aliquoting information
Storage information
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
The IWS1 protein is involved in mediating interactions between the transcription machinery and chromatin. IWS1 often functions as a part of the transcription elongation complex enhancing the efficiency of RNA polymerase II during the elongation phase of transcription. IWS1 as part of this complex assists in chromatin remodeling which allows for the transcription of tightly packaged DNA. This action facilitates efficient gene expression and is important in maintaining proper cellular functions and responses to environmental signals.
Pathways
IWS1 integrates into critical cellular processes like the cell cycle and DNA damage response pathways. One significant pathway is the RNA polymerase II transcription elongation pathway where IWS1 works closely with other elongation factors and chromatin remodeling proteins to ensure proper transcription regulation. Additionally IWS1 is associated with the DNA damage response pathway where it collaborates with proteins such as ATR and BRCA1 to manage cellular reactions to DNA damage contributing to genome stability and repair mechanisms.
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Target data
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