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AB226814

Anti-Jagged 2/JAG2 antibody

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(3 Publications)

Rabbit Polyclonal Jagged 2/JAG2 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human JAG2.

View Alternative Names

Protein jagged-2, Jagged2, hJ2, JAG2

1 Images
Western blot - Anti-Jagged 2/JAG2 antibody (AB226814)
  • WB

Supplier Data

Western blot - Anti-Jagged 2/JAG2 antibody (AB226814)

All lanes:

Western blot - Anti-Jagged 2/JAG2 antibody (ab226814) at 1/1000 dilution

All lanes:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate at 30 µg

Predicted band size: 133 kDa,55 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human JAG2. The exact immunogen used to generate this antibody is proprietary information.

Q9Y219

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.025% Proclin 300 Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Jagged 2 (JAG2) also known as JAGGED 2 is a membrane-bound ligand that weighs about 135 kDa. It interacts with the Notch family receptors to initiate signaling events that regulate cell fate decisions. JAG2 expresses in various tissues with high levels in neural hematopoietic and muscular systems. Its mechanical function involves binding to the Notch receptor on adjacent cells facilitating proteolytic cleavage and activation of the receptor's intracellular domain which then translocates to the nucleus to influence gene expression.
Biological function summary

The JAG2 protein plays a significant role in development and differentiation processes. It acts as a ligand in the Notch signaling pathway which includes other ligands like Jagged 1 (JAG1) and Delta-like proteins. In this complex JAG2 modulates neurogenesis myogenesis and angiogenesis. By affecting these processes JAG2 contributes to tissue homeostasis and the regulation of stem cells.

Pathways

The Notch signaling pathway involving JAG2 plays an important role in cell-cell communication. JAG2 activity in this pathway impact pathways like T-cell development and bone remodeling. It interacts with proteins like Notch1 and RBP-Jκ forming a pivotal part of the regulatory circuit that manages cell differentiation and proliferation.

Researchers link JAG2 to various conditions notably cancer and skeletal disorders. Dysregulation of JAG2 in the Notch pathway can contribute to oncogenesis with increased JAG2 expression observed in certain breast cancers. Additionally interactions between JAG2 and the Notch receptors influence bone diseases as alterations in signaling affect bone density and structure. Understanding the role of JAG2 and related proteins in these pathways allows potential therapeutic targeting in these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity).
See full target information JAG2
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Journal of Cancer 16:445-459 PubMed39744480

2025

NCAPG promotes the malignant progression of endometrioid cancer through LEF1/SEMA7A/PI3K-AKT.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Ren,Xiaohan Li,Chun Fu

Nature communications 15:438 PubMed38200007

2024

Disparate macrophage responses are linked to infection outcome of Hantan virus in humans or rodents.

Applications

Unspecified application

Species

Unspecified reactive species

Hongwei Ma,Yongheng Yang,Tiejian Nie,Rong Yan,Yue Si,Jing Wei,Mengyun Li,He Liu,Wei Ye,Hui Zhang,Linfeng Cheng,Liang Zhang,Xin Lv,Limin Luo,Zhikai Xu,Xijing Zhang,Yingfeng Lei,Fanglin Zhang

Cell death & disease 11:307 PubMed32366833

2020

Atypical chemokine receptor ACKR3/CXCR7 controls postnatal vasculogenesis and arterial specification by mesenchymal stem cells via Notch signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Sung-Tai Wei,Yen-Chih Huang,Mei-Ling Hsieh,Yu-Jung Lin,Woei-Cherng Shyu,Hui-Chen Chen,Chia-Hung Hsieh
View all publications
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Product promise

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