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AB237735

Anti-JAGN1 antibody

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(1 Publication)

Rabbit Polyclonal JAGN1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human JAGN1 aa 1-50.

View Alternative Names

Protein jagunal homolog 1, JAGN1

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JAGN1 antibody (AB237735)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JAGN1 antibody (AB237735)

Paraffin-embedded human adrenal gland tissue stained for JAGN1 using ab237735 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-JAGN1 antibody (AB237735)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-JAGN1 antibody (AB237735)

A549 (human lung carcinoma cell line) cells stained for JAGN1 (green) using ab237735 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JAGN1 antibody (AB237735)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-JAGN1 antibody (AB237735)

Paraffin-embedded human colon cancer tissue stained for JAGN1 using ab237735 at 1/100 dilution in immunohistochemical analysis.

Western blot - Anti-JAGN1 antibody (AB237735)
  • WB

Supplier Data

Western blot - Anti-JAGN1 antibody (AB237735)

All lanes:

Western blot - Anti-JAGN1 antibody (ab237735) at 1/500 dilution

All lanes:

HL-60 (human promyelocytic leukemia cell line) whole cell lysate

Secondary

All lanes:

Goat polyclonal to rabbit at 1/10000 dilution

Predicted band size: 21 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human JAGN1 aa 1-50. The exact immunogen used to generate this antibody is proprietary information.

Q8N5M9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein G
Purification notes
Purity greater than 95%.
Storage buffer
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

JAGN1 also known as Jagunal homolog 1 is a protein expressed in various tissues including the bone marrow and immune cells. The protein has a mass of approximately 18 kDa. JAGN1 plays a role in the endoplasmic reticulum where it is involved in the process of protein maturation and trafficking. It is a vital component in ensuring proper glycosylation of proteins which is important for their stability and function.
Biological function summary

The protein aids in cellular processes linked to immune cell function and development. It forms part of a complex that participates in the secretory pathway influencing how proteins are processed and transported within cells. This involvement directly impacts the immune response as it ensures that immune cells mature correctly and are functionally active.

Pathways

JAGN1 plays a significant role in the N-linked glycosylation pathway an important process necessary for protein folding and stability. It interacts with other proteins like Dolichyl-Diphosphooligosaccharide-Protein Glycosyltransferase to effectively carry out its glycosylation functions. Another important pathway includes the unfolded protein response pathway which involves proteins like IRE1 and PERK important for maintaining cellular homeostasis under stress conditions.

JAGN1 has been linked to severe congenital neutropenia a disorder affecting the production and function of neutrophils important immune cells. Mutations in the JAGN1 gene have been observed in patients with this condition leading to increased vulnerability to infections. Furthermore research suggests a potential connection with asthma where it may affect immune cell function and inflammatory responses. Through these conditions JAGN1 interacts with proteins like ELANE and CSF3R further elucidating its importance in immune-related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Endoplasmic reticulum transmembrane protein involved in vesicle-mediated transport, which is required for neutrophil function. Required for vesicle-mediated transport; it is however unclear whether it is involved in early secretory pathway or intracellular protein transport. Acts as a regulator of neutrophil function, probably via its role in vesicle-mediated transport : required for defense against fungal pathogens and for granulocyte colony-stimulating factor (GM-CSF) signaling pathway; possibly by regulating glycosylation and/or targeting of proteins contributing to the viability and migration of neutrophils.
See full target information JAGN1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of cancer research and clinical oncology 150:214 PubMed38662050

2024

High core 1β1,3-galactosyltransferase 1 expression is associated with poor prognosis and promotes cellular radioresistance in lung adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Chen,Yanyan Ji,Lin Shen,Ying Li,Yue Ren,Hongcan Shi,Yue Li,Yunjiang Wu
View all publications
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