Anti-Japanese encephalitis virus antibody

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Biological function summary

The Japanese encephalitis virus impacts the central nervous system by invading human and animal neurons. During infection the virus forms a complex with the host cell machinery using it for viral replication and protein synthesis. It also causes an immune response involving immune cells that are trying to eliminate the virus further contributing to neural damage and inflammation.

Pathways

The Japanese encephalitis virus participates in the interferon signaling pathway and the Toll-like receptor signaling pathway. These pathways are critical for the host's antiviral defense. The virus can alter these pathways to favor its own survival and replication by interacting with host proteins such as STAT1 and STAT2 in the interferon pathway. Its ability to interfere with these pathways results in evasion of the host's immune response leading to prolonged infection.