Anti-JM4/PRAF2 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

JM4 also known as PRAF2 (PRA1 domain family member 2) is a small protein with a molecular mass of approximately 21 kDa. It is expressed mainly in the brain hinting at a role in neurological functions. PRAF2 contains several transmembrane domains and is localized primarily to the Golgi apparatus and endosomal structures within cells. This localization suggests potential involvement in intracellular trafficking processes.

Biological function summary

PRAF2 participates in several cellular mechanisms related to vesicular transport and signal transduction. It is not independently acting; rather it forms part of a complex that includes other PRA family members. By interacting with these proteins PRAF2 helps modulate cell signaling pathways that can impact neuronal communication and cellular responses. The roles in signaling and transport suggest PRAF2's importance for cellular homeostasis and neuronal function.

Pathways

PRAF2 plays roles in multiple important biological cascades such as the neuronal signaling and vesicular transport pathways. Within these processes its interaction with proteins like Rab GTPases is significant as these help regulate vesicle movement and neurotransmitter release. These interactions hint at PRAF2’s role in maintaining the proper function and dynamic balance necessary for neurological health.

Associated diseases and disorders

Research implicates PRAF2 in conditions like glioblastoma and schizophrenia. Its upregulation has been observed in glioblastoma suggesting a possible role in tumor growth or progression. In schizophrenia altered PRAF2 expression may affect neurotransmitter systems aligning with symptoms of the disorder. Connections with related proteins such as PRAF1 and other Rab GTPases further highlight PRAF2's involvement in pathogenic processes that underline these diseases.