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AB130922

Anti-JMJD1C antibody

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(3 Publications)

Rabbit Polyclonal JMJD1C antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human JMJD1C aa 150-200.

View Alternative Names

JHDM2C, KDM3C, KIAA1380, TRIP8, JMJD1C, Jumonji domain-containing protein 1C, Thyroid receptor-interacting protein 8, TR-interacting protein 8, TRIP-8

1 Images
Western blot - Anti-JMJD1C antibody (AB130922)
  • WB

Unknown

Western blot - Anti-JMJD1C antibody (AB130922)

All lanes:

Western blot - Anti-JMJD1C antibody (ab130922) at 0.04 µg/mL

Lane 1:

HeLa whole cell lysate at 50 µg

Lane 2:

HeLa whole cell lysate at 15 µg

Lane 3:

HeLa whole cell lysate at 5 µg

Lane 4:

293T whole cell lysate at 15 µg

Predicted band size: 284 kDa

true

Exposure time: 3min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human JMJD1C aa 150-200. The exact immunogen used to generate this antibody is proprietary information.

Q15652

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified using an epitope specific to JMJD1C immobilized on solid support.
Storage buffer
Preservative: 0.09% Sodium azide Constituents: 99% Tris buffered saline, 0.1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

JMJD1C also known as KDM3C is a member of the Jumonji domain-containing proteins family. It acts as a histone demethylase specifically targeting histone H3 at lysine 9 (H3K9). This enzymatic function plays a role in epigenetic regulation by removing methyl groups from histone proteins influencing chromatin structure and gene expression. The protein has an approximate molecular mass of 170 kDa. It is expressed in various tissues with significant levels found in the testis brain and other central nervous system components.
Biological function summary

JMJD1C regulates gene expression linked to spermatogenesis metabolic processes and neurodevelopmental signaling. It interacts with components of transcriptional complexes having a role in the demethylation of histones to facilitate transcription. The protein also controls hormonal responses by influencing androgen receptor signaling pathways which is important in reproductive tissue function and development.

Pathways

JMJD1C integrates into metabolic and developmental regulatory networks. It is actively involved in the androgen receptor signaling pathway and the Wnt signaling pathway. Its interactions with proteins such as AR (androgen receptor) and components of the Wnt signaling orchestrate gene transcription impacting cellular growth and differentiation. By modulating these pathways JMJD1C links epigenetic modifications to broader physiological processes.

JMJD1C has been associated with cancer and neuropsychiatric disorders. Aberrant expression or mutation of JMJD1C can contribute to prostate cancer given its role in androgen receptor pathways and it has also been implicated in schizophrenia where it may influence neuronal gene expression. The protein's interaction with the androgen receptor and other transcription factors highlights its significance in these pathologies suggesting potential as a therapeutic target.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Demethylates lysine in proteins, such as STAT3 or MDC1 (By similarity) (PubMed : 24240613). Demethylates MDC1, thereby promoting MDC1-RNF8 interaction and facilitating RNF8-dependent MDC1 ubiquitination essential for double-strand break (DSB) repair (PubMed : 24240613). Demethylation of STAT3 at 'Lys-140' facilitates its interactions with the phosphatase PTPN6 and restrains STAT3 activation (By similarity). It is uncertain whether JMJD1C removes methyl groups from histone proteins as the other JMJD1/KDM3 proteins do (PubMed : 23593242, PubMed : 24240613, PubMed : 32034158). Nevertheless, JMJD1C may act as a context-specific histone demethylase. Implicated in lipogenic gene transcription in the liver, where USF1 recruits JMJD1C to lipogenic promoters in response to insulin or feeding stimuli, thereby potentially promoting H3K9me2 demethylation and enhancing chromatin accessibility (PubMed : 32034158). Post-translational modifications may regulate JMJD1C's enzymatic activity, contributing to its context-specific functions (PubMed : 32034158). Alternatively, JMJD1C may influence chromatin regulation indirectly, acting as a scaffold or co-regulator that recruits or stabilizes other active demethylase complexes modifying histone marks (PubMed : 24240613). Plays an indispensable role in spermatogenesis (By similarity).. Isoform 3. Coactivator of androgen receptor.
See full target information JMJD1C
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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Cellular and molecular biology (Noisy-le-Grand, France) 70:204-211 PubMed38650133

2024

circ_JMJD1C expedites breast cancer progression by regulating miR-182-5p/JMJD1C/SOX4 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Renyuan Xu,Haomiao Lan,Li Zhang,Sisi Yang,Yu Mao,Hongying Che

Cancer cell international 21:273 PubMed34022910

2021

Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis.

Applications

Unspecified application

Species

Unspecified reactive species

Fanyong Qu,Lina Wang,Caiyan Wang,Lingxia Yu,Kaikai Zhao,Hao Zhong

Genetics and molecular research : GMR 14:18249-58 PubMed26782472

2015

Expression pattern of JMJD1C in oocytes and its impact on early embryonic development.

Applications

Unspecified application

Species

Unspecified reactive species

C H Li,Y Gao,S Wang,F F Xu,L S Dai,H Jiang,X F Yu,C Z Chen,B Yuan,J B Zhang
View all publications
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Product promise

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