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AB79067

Anti-JP-4 antibody

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(2 Publications)

Rabbit Polyclonal JP-4 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human JPH4.

View Alternative Names

JPHL1, KIAA1831, JPH4, Junctophilin-4, JP-4, Junctophilin-like 1 protein

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-JP-4 antibody (AB79067)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-JP-4 antibody (AB79067)

Immunofluorescence of JP-4 in Human Brain cells using ab79067 at 20 ug/ml.

Western blot - Anti-JP-4 antibody (AB79067)
  • WB

Unknown

Western blot - Anti-JP-4 antibody (AB79067)

All lanes:

Western blot - Anti-JP-4 antibody (ab79067) at 1 µg/mL

Lane 1:

293 cell lysate at 15 µg

Lane 2:

293 cell lysate with blocking peptide at 15 µg

Predicted band size: 66 kDa

Observed band size: 66 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human JPH4. The exact immunogen used to generate this antibody is proprietary information.

Q96JJ6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-2 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Affinity chromatography purified via peptide column
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
+4°C
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

JP-4 also known as Junction Protein-4 is a 45 kDa protein that functions mechanically as a structural component in cellular junctions. It is expressed primarily in epithelial cells and assists in maintaining cell-cell adhesion and integrity. The protein is also seen in neural tissues where it plays a similar role in facilitating intercellular connections.
Biological function summary

JP-4 contributes to cellular communication and tissue stability through its involvement in cell junction assembly. It often forms part of a complex with other junctional proteins enhancing the strength and coordination of cellular connections. This protein stabilizes junctional connections ensuring effective communication between adjacent cells and maintaining tissue homeostasis.

Pathways

Cellular adhesion pathways and neural signaling processes incorporate JP-4. It interacts within the cadherin-mediated cell junction pathway associating with proteins such as E-cadherin and beta-catenin and aids in mediating adhesive interactions critical for tissue architecture. Additionally JP-4 involvement in neural pathways suggests a role in synaptic stability and neurotransmitter fluidity.

Abnormalities in JP-4 have associations with epithelial barrier dysfunctions and neurodegenerative conditions. In inflammatory bowel disease dysfunctional JP-4 disrupts epithelial barriers impairing digestive system integrity. Its interactions with neural proteins such as synapsin indicate potential links to disorders like Alzheimer's disease where synaptic connections deteriorate.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH4 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory (By similarity).
See full target information JPH4
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Cell reports 28:2427-2442.e6 PubMed31461656

2019

Junctophilin Proteins Tether a Cav1-RyR2-KCa3.1 Tripartite Complex to Regulate Neuronal Excitability.

Applications

Unspecified application

Species

Unspecified reactive species

Giriraj Sahu,Rima-Marie Wazen,Pina Colarusso,S R Wayne Chen,Gerald W Zamponi,Ray W Turner

The Journal of investigative dermatology 136:1355-1363 PubMed27021406

2016

Epithelium-Derived Wnt Ligands Are Essential for Maintenance of Underlying Digit Bone.

Applications

Unspecified application

Species

Unspecified reactive species

Makoto Takeo,Christopher S Hale,Mayumi Ito
View all publications
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