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Rabbit Polyclonal Junin antibody. Suitable for WB and reacts with Argentinian mammarenavirus samples. Immunogen corresponding to Virus preparation containing Junin protein.

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Images

Western blot - Anti-Junin antibody (AB190477), expandable thumbnail

Key facts

Isotype

IgG

Host species

Rabbit

Storage buffer

Preservative: 0.01% Sodium azide
Constituents: 99% PBS

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Virus preparation containing Junin protein. The exact immunogen used to generate this antibody is proprietary information.

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Argentinian mammarenavirus
Tested

Tested
Tested

Species

Argentinian mammarenavirus

Dilution info

-

Notes

If probing against purified infected cell supernatant, cross-adsorption recommended.

Targets

Junin

Recommended products

Rabbit Polyclonal Junin antibody. Suitable for WB and reacts with Argentinian mammarenavirus samples. Immunogen corresponding to Virus preparation containing Junin protein.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Virus preparation containing Junin protein. The exact immunogen used to generate this antibody is proprietary information.
Purification technique

Affinity purification Protein A

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Candid #1 represents a surrogate strain for the Category A (NIAID) and HHS Select Agent Junin virus.

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

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Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Junin virus encodes the Junin virus glycoprotein an important component of its envelop structure with a molecular mass of approximately 75 kilodaltons. This glycoprotein often abbreviated JUNV GP facilitates the virus's entry into host cells. It mediates cell attachment and fusion mainly expressed in the cells lining respiratory and endothelial tissues. JUNV GP interacts with host receptors to initiate viral infection efficiently contributing to the virus's transmission cycle.

Biological function summary

The Junin virus glycoprotein plays a role in viral replication and immune evasion. It constructs a complex with other viral proteins integral to the formation of a functional viral particle. The glycoprotein is recognized by the host's immune system yet it undergoes mutations that help escape immune detection. These adaptations ensure the persistence and survival of the virus within the infected host affecting the host's ability to mount an effective immune response.

Pathways

The Junin virus glycoprotein is important in mechanisms of viral entry and immune modulation. The notable pathways include the cellular receptor-mediated endocytosis and the interferon signaling pathways. Within these pathways JUNV GP interacts with proteins such as transferrin receptor 1 facilitating viral entry and affects the function of host interferon-stimulated genes by interfering with antiviral responses.

Associated diseases and disorders

Junin virus glycoprotein is linked to Argentine hemorrhagic fever a severe disease caused by Junin virus infection. This disease presents symptoms like fever bleeding and shock. The immune system's failure to target JUNV GP effectively is partly responsible for the disease's progression. The glycoprotein's interaction with host proteins like transferrin receptor 1 plays a role in the virus's pathogenicity contributing to the disease's severe manifestation.

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1 product image

  • Western blot - Anti-Junin antibody (ab190477), expandable thumbnail

    Western blot - Anti-Junin antibody (ab190477)

    ab190477 was diluted to 1 μg/ml and incubated with 2% FBS for 2 hours prior to blotting.

    All lanes: Western blot - Anti-Junin antibody (ab190477) at 1 µg/mL

    All lanes: Sucrose-purified infected cell supernatant

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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