Rabbit Polyclonal Junin antibody. Suitable for WB and reacts with Argentinian mammarenavirus samples. Immunogen corresponding to Virus preparation containing Junin protein.
IgG
Rabbit
Preservative: 0.01% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
WB | |
---|---|
Argentinian mammarenavirus | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Argentinian mammarenavirus | Dilution info - | Notes If probing against purified infected cell supernatant, cross-adsorption recommended. |
Junin
Rabbit Polyclonal Junin antibody. Suitable for WB and reacts with Argentinian mammarenavirus samples. Immunogen corresponding to Virus preparation containing Junin protein.
IgG
Rabbit
Preservative: 0.01% Sodium azide
Constituents: 99% PBS
Liquid
Polyclonal
Affinity purification Protein A
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
Candid #1 represents a surrogate strain for the Category A (NIAID) and HHS Select Agent Junin virus.
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
This supplementary information is collated from multiple sources and compiled automatically.
Junin virus encodes the Junin virus glycoprotein an important component of its envelop structure with a molecular mass of approximately 75 kilodaltons. This glycoprotein often abbreviated JUNV GP facilitates the virus's entry into host cells. It mediates cell attachment and fusion mainly expressed in the cells lining respiratory and endothelial tissues. JUNV GP interacts with host receptors to initiate viral infection efficiently contributing to the virus's transmission cycle.
The Junin virus glycoprotein plays a role in viral replication and immune evasion. It constructs a complex with other viral proteins integral to the formation of a functional viral particle. The glycoprotein is recognized by the host's immune system yet it undergoes mutations that help escape immune detection. These adaptations ensure the persistence and survival of the virus within the infected host affecting the host's ability to mount an effective immune response.
The Junin virus glycoprotein is important in mechanisms of viral entry and immune modulation. The notable pathways include the cellular receptor-mediated endocytosis and the interferon signaling pathways. Within these pathways JUNV GP interacts with proteins such as transferrin receptor 1 facilitating viral entry and affects the function of host interferon-stimulated genes by interfering with antiviral responses.
Junin virus glycoprotein is linked to Argentine hemorrhagic fever a severe disease caused by Junin virus infection. This disease presents symptoms like fever bleeding and shock. The immune system's failure to target JUNV GP effectively is partly responsible for the disease's progression. The glycoprotein's interaction with host proteins like transferrin receptor 1 plays a role in the virus's pathogenicity contributing to the disease's severe manifestation.
We have tested this species and application combination and it works. It is covered by our product promise.
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
We do not recommend this combination. It is not covered by our product promise.
We are dedicated to supporting your work with high quality reagents and we are here for you every step of the way should you need us.
In the unlikely event of one of our products not working as expected, you are covered by our product promise.
Full details and terms and conditions can be found here:
Terms & Conditions.
ab190477 was diluted to 1 μg/ml and incubated with 2% FBS for 2 hours prior to blotting.
All lanes: Western blot - Anti-Junin antibody (ab190477) at 1 µg/mL
All lanes: Sucrose-purified infected cell supernatant
Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.
For licensing inquiries, please contact partnerships@abcam.com