AB197845

Anti-K Cadherin/CDH6 antibody

Name: Anti-K Cadherin/CDH6 antibody (ab197845) | Abcam
Brand: Abcam Limited
SKU: AB197845
Price: 535 USD
Availability: InStock
Rating: 4 (2 reviews)

(2 Reviews)

(3 Publications)

Rabbit Polyclonal K Cadherin/CDH6 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Fusion protein corresponding to CDH6, fused to CDH6.

View Alternative Names

Cadherin-6, Kidney cadherin, K-cadherin, CDH6

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K Cadherin/CDH6 antibody (AB197845)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K Cadherin/CDH6 antibody (AB197845)

Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling K Cadherin/CDH6 with ab197845 at 1/50 dilution.

Supplier Data

Western blot - Anti-K Cadherin/CDH6 antibody (AB197845)

Gel : 8%SDS-PAGE

All lanes:

Western blot - Anti-K Cadherin/CDH6 antibody (ab197845) at 1/500 dilution

Lane 1:

HeLa cell lysate at 40 µg

Lane 2:

A549 cell lysate at 40 µg

Lane 3:

Human liver cancer tissue lysate at 40 µg

Lane 4:

HT29 cell lysate at 40 µg

Predicted band size: 88 kDa

false

Exposure time: 2min

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Fusion protein corresponding to CDH6, fused to CDH6. The exact immunogen used to generate this antibody is proprietary information.

P55285

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

K Cadherin also known as CDH6 K-Cadherin or Cadherin-6 is a protein that plays a significant mechanical role in cell adhesion. It belongs to the cadherin superfamily of proteins which are known for their role in calcium-dependent cell-cell adhesion. The CDH6 protein has an approximate molecular mass of 88 kDa. It is mainly expressed in the kidney brain and pancreas where it contributes to maintaining proper cellular architecture and signaling.

Biological function summary

Cadherin-6 is involved in the dynamic regulation of tissue morphogenesis and neural development. It interacts with intracellular catenins to form a cadherin-catenin complex which links to the actin cytoskeleton. This complex is essential for transmitting mechanical signals and maintaining cellular structure. CDH6 plays a critical role in branching morphogenesis and neuronal connectivity aiding in the formation of organized tissue architecture and neural networks.

Pathways

Cadherin-6 is a component of the Wnt signaling pathway which influences cell fate determination and patterning. CDH6 interacts with related proteins like beta-catenin facilitating the transduction of signals within the Wnt pathway. Additionally it is part of the epithelial-mesenchymal transition (EMT) pathway where it influences cell migration and differentiation by interacting with growth factor receptors and downstream signaling molecules.

Dysregulation of cadherin-6 expression links to various cancers such as renal cell carcinoma and glioblastoma. In these contexts altered CDH6 levels can impact tumor progression and metastatic potential. Furthermore its interplay with proteins like E-cadherin and integrins affects cellular proliferation and invasion highlighting the importance of CDH6 in cancer biology.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.

See full target information CDH6

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 38:e23602 PubMed38581236

2024

Neurotensin modulates ovarian vascular permeability via adherens junctions.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew C Pearson,Ketan Shrestha,Thomas E Curry,Diane M Duffy

Frontiers in cell and developmental biology 10:699144 PubMed35356283

2022

Molecular Characterization of Differentiated-Resistance MSC Subclones by Single-Cell Transcriptomes.

Applications

Unspecified application

Species

Unspecified reactive species

Andres Stucky,Li Gao,Shengwen Calvin Li,Lingli Tu,Jun Luo,Xi Huang,Xuelian Chen,Xiaoqing Li,Tiffany H Park,Jin Cai,Mustafa H Kabeer,Ashley S Plant,Lan Sun,Xi Zhang,Jiang F Zhong

Oncotarget 7:69871-69882 PubMed27563818

2016

Cadherin-6 type 2, K-cadherin (CDH6) is regulated by mutant p53 in the fallopian tube but is not expressed in the ovarian surface.

Applications

IHC, WB

Species

Unspecified reactive species, Unspecified reactive species

Subbulakshmi Karthikeyan,Daniel D Lantvit,Dam Hee Chae,Joanna E Burdette

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-K Cadherin/CDH6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K Cadherin/CDH6 antibody (AB197845)

Western blot - Anti-K Cadherin/CDH6 antibody (AB197845)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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