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AB233139

Anti-K33A antibody

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(1 Publication)

Rabbit Polyclonal K33A antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KRT33A aa 50-400.

View Alternative Names

HHA3-I, HKA3A, KRTHA3A, KRT33A, Keratin-33A, K33A

9 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)

Formalin-fixed, paraffin-embedded human liver tissue stained for K33A using ab233139 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)

Formalin-fixed, paraffin-embedded human prostate cancer tissue stained for K33A using ab233139 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)

Formalin-fixed, paraffin-embedded human kidney tissue stained for K33A using ab233139 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)

Formalin-fixed, paraffin-embedded human glioma tissue stained for K33A using ab233139 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)

Formalin-fixed, paraffin-embedded human liver cancer tissue stained for K33A using ab233139 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-K33A antibody (AB233139)

Formalin-fixed, paraffin-embedded human cerebrum tissue stained for K33A using ab233139 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-K33A antibody (AB233139)
  • WB

Supplier Data

Western blot - Anti-K33A antibody (AB233139)

All lanes:

Western blot - Anti-K33A antibody (ab233139) at 1 µg/mL

All lanes:

Human lung lysate

Predicted band size: 46 kDa

false

Western blot - Anti-K33A antibody (AB233139)
  • WB

Supplier Data

Western blot - Anti-K33A antibody (AB233139)

All lanes:

Western blot - Anti-K33A antibody (ab233139) at 2 µg

All lanes:

Recombinant human K33A protein

Predicted band size: 46 kDa

false

Western blot - Anti-K33A antibody (AB233139)
  • WB

Supplier Data

Western blot - Anti-K33A antibody (AB233139)

All lanes:

Western blot - Anti-K33A antibody (ab233139) at 1 µg

All lanes:

Mouse testis lysate

Predicted band size: 46 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human KRT33A aa 50-400. The exact immunogen used to generate this antibody is proprietary information.

O76009

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.2-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

K33A also known as Katanin p60 subunit A1 is a microtubule-severing ATPase that plays a significant role in cellular function. This protein has a mass of approximately 60 kDa and is expressed in a variety of tissues with particular abundance in neural tissues. K33A functions by cutting microtubules which are essential components of the cytoskeleton into smaller pieces facilitating cellular processes like mitosis and migration.
Biological function summary

The ability of K33A to sever microtubules affects the dynamic restructuring of the cytoskeleton which is essential for cell division and intracellular transport. It often operates as part of a protein complex with other proteins such as Katanin p80 which regulates its activity. This activity is important for maintaining proper microtubule network organization which influences cellular architecture and function.

Pathways

The severing action K33A performs is essential in the regulation of the microtubule dynamics pathway. This pathway plays a critical role in cellular events like signal transduction where K33A interacts with and modulates the behavior of microtubules. K33A also indirectly connects with proteins like Tau which stabilizes microtubules suggesting its significant involvement in maintaining cellular stability and transport.

Mutations or dysregulation in K33A expression have links to neurological diseases such as spastic paraplegia and neurodegeneration disorders. Neurodegeneration often involves the abnormal behavior of K33A's interacting protein Tau leading to disrupted cellular transport and stability. Understanding these connections emphasizes the importance of K33A in neuronal health and disease pathology.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information KRT33A
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

BMC genomics 24:200 PubMed37055767

2023

Proteomic profiles and the function of RBP4 in endometrium during embryo implantation phases in pigs.

Applications

Unspecified application

Species

Unspecified reactive species

Yueying Wang,Songyi Xue,Qiaorui Liu,Dengying Gao,Renwu Hua,Minggang Lei
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