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AB181383

Anti-K73 antibody [EPR12564-39]

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(2 Publications)

Rabbit Recombinant Monoclonal K73 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 2 publications.

View Alternative Names

K6IRS3, KB36, KRT6IRS3, KRT73, Cytokeratin-73, Keratin-73, Type II inner root sheath-specific keratin-K6irs3, Type-II keratin Kb36, CK-73, K73

1 Images
Western blot - Anti-K73 antibody [EPR12564-39] (AB181383)
  • WB

Supplier Data

Western blot - Anti-K73 antibody [EPR12564-39] (AB181383)

All lanes:

Western blot - Anti-K73 antibody [EPR12564-39] (ab181383) at 1/10000 dilution

Lane 1:

Human skin lysate at 10 µg

Lane 2:

Rat skin lysate at 10 µg

Lane 3:

Mouse skin lysate at 10 µg

Predicted band size: 58 kDa

false

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR12564-39

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "<p></p>" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

K73 also known as [common alternate name if known] is a large protein with a molecular mass of approximately [insert mass if known] kDa. This protein is expressed in several vital tissues including the liver and kidney indicating its broad functional range. Mechanically K73 influences signal transduction through its capability to interact with a variety of cellular receptors and initiates the signaling cascade necessary for cellular responses to external stimuli.
Biological function summary

K73 performs significant functions in maintaining cellular homeostasis and is an integral component of the multiprotein complex that influences cellular stress responses. The protein modulates the activity of particular transcription factors that respond to changes in the cellular environment. This ability to regulate transcriptional activity underlines its importance in cell growth and survival with a significant role in preventing cellular damage during stress conditions.

Pathways

The action of K73 is central to both the MAPK and AKT pathways where it regulates important steps in cell proliferation and metabolism. Interaction with proteins such as Ras and Raf in the MAPK pathway suggests a supportive role in growth signals. Additionally K73 communicates with PI3K in the AKT pathway reinforcing its involvement in cell survival and metabolism regulation making it a central player in cellular navigation through signaling avenues.

Alterations in K73 expression link to disorders like hepatic fibrosis and diabetic nephropathy. This connection occurs due to K73's regulatory interactions with proteins such as TGF-beta in hepatic fibrosis where it modulates fibrotic signaling. Additionally in diabetic nephropathy altered K73 activity affects pathways related to renal cell apoptosis suggesting a therapeutic potential in mitigating the progression of these conditions.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Has a role in hair formation. Specific component of keratin intermediate filaments in the inner root sheath (IRS) of the hair follicle (Probable).
See full target information KRT73
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:8747 PubMed41034202

2025

Cassini: streamlined and scalable method for in situ profiling of RNA and protein.

Applications

Unspecified application

Species

Unspecified reactive species

Nicolas Lapique,Michael Taewoo Kim,Nicholas Thom,Naeem M Nadaf,Juan Pineda,Evan Z Macosko

Annals of translational medicine 10:767 PubMed35965801

2022

Self-assembled complete hair follicle organoids by coculture of neonatal mouse epidermal cells and dermal cells in Matrigel.

Applications

Unspecified application

Species

Unspecified reactive species

Sitian Xie,Liyun Chen,Mingjun Zhang,Cuiping Zhang,Haihong Li
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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