AB131038

Anti-Kallikrein 11 antibody

Name: Anti-Kallikrein 11 antibody (ab131038) | Abcam
Brand: Abcam Limited
SKU: AB131038
Price: 520 USD
Availability: InStock

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(1 Publication)

Rabbit Polyclonal Kallikrein 11 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KLK11.

View Alternative Names

PRSS20, TLSP, UNQ649/PRO1279, KLK11, Kallikrein-11, hK11, Hippostasin, Serine protease 20, Trypsin-like protease

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (AB131038)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (AB131038)

Immunohistochemical analysis of paraffin-embedded Human prostatic cancer tissue labelling Kallikrein 11 with ab131038 at 0.5 μg/ml.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (AB131038)

Paraffin embedded zebrafish tissue stained for BHMT with ab131038 (1/300) in Immunohistochemical analysis.

Unknown

Western blot - Anti-Kallikrein 11 antibody (AB131038)

All lanes:

Western blot - Anti-Kallikrein 11 antibody (ab131038) at 0.1 µg/mL

Lane 1:

M231 cell lysate

Lane 2:

M453 cell lysate

Lane 3:

Jurkat cell lysate

Lane 4:

COLO320 cell lysate

Lane 5:

HT1080 cell lysate

Lane 6:

COLO320 Cell Lysate

Lane 7:

JURKAT Cell Lysate

Predicted band size: 31 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Synthetic Peptide within Human KLK11. The exact immunogen used to generate this antibody is proprietary information.

Q9UBX7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kallikrein 11 also known as hK11 is a secreted serine protease enzyme encoded by the KLK11 gene. It has an average molecular mass of approximately 30 kDa. This enzyme is mainly produced in various tissues including prostate spleen and thyroid playing a role in proteolytic processing. Kallikrein 11 has a function in post-translational modifications contributing to the activation and regulation of other proteins through cleavage.

Biological function summary

Kallikrein 11 functions as a significant participant in seminal fluid production and sperm motility. It plays roles in maintenance and regulation of these physiological processes. Kallikrein 11 is part of the extensive kallikrein-related peptidase family; hence it shares functional characteristics with other serine proteases in this family. It contributes to the breaking down of extracellular matrix proteins implicating it in tissue remodeling.

Pathways

Kallikrein 11 integrates into the kallikrein-kinin system and affects components involved in this biochemical network. This system impacts blood pressure regulation and inflammation processes. Kallikrein 11 acts in conjunction with other kallikreins and kinins leading to potential modulation of inflammatory responses and vascular functions. Its actions are related to pathways involving proteins such as prostatic acid phosphatase and prostate-specific antigen (PSA).

Kallikrein 11 has been implicated in prostate cancer and Alzheimer's disease. Increased expression of kallikrein 11 correlates with prostate cancer progression and serves as a potential biomarker for this condition. Additionally research suggests an association between aberrant kallikrein activity and Alzheimer's pathology though this involves more intricate enzymatic pathways with proteins like amyloid precursor protein (APP). Understanding its role in these diseases may offer new therapeutic avenues.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.

See full target information KLK11

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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

American journal of cancer research 8:1856-1864 PubMed30323977

2018

Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaocong Geng,Yueyang Liu,Tobias Dreyer,Holger Bronger,Enken Drecoll,Viktor Magdolen,Julia Dorn

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Kallikrein 11 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (AB131038)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (AB131038)

Western blot - Anti-Kallikrein 11 antibody (AB131038)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (1)

Product promise