Rabbit Polyclonal Kallikrein 11 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KLK11.
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- American journal of cancer research 8:1856-18642018Elevated tumor tissue protein expression levels of kallikrein-related peptidases KLK10 and KLK11 are associated with a better prognosis in advanced high-grade serous ovarian cancer patients.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXiaocong Geng,Yueyang Liu,Tobias Dreyer,Holger Bronger,Enken Drecoll,Viktor Magdolen,Julia DornPubMed 30323977
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Synthetic Peptide within Human KLK11. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UBX7
Reactivity data
Select an application| IHC-P | WB | |
|---|---|---|
| Human | Tested | Tested |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.50000-1.00000 µg/mL | Notes Perform heat-mediated antigen retrieval before commencing with IHC staining protocol. |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 0.10000-0.50000 µg/mL | Notes - |
Associated Products
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1 product for Alternative Product
Target data
Function
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
Alternative names
PRSS20, TLSP, UNQ649/PRO1279, KLK11, Kallikrein-11, hK11, Hippostasin, Serine protease 20, Trypsin-like protease
Recommended products
Rabbit Polyclonal Kallikrein 11 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KLK11.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate)
Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Synthetic Peptide within Human KLK11. The exact immunogen used to generate this antibody is proprietary information. Database link Q9UBX7
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
Kallikrein 11 also known as hK11 is a secreted serine protease enzyme encoded by the KLK11 gene. It has an average molecular mass of approximately 30 kDa. This enzyme is mainly produced in various tissues including prostate spleen and thyroid playing a role in proteolytic processing. Kallikrein 11 has a function in post-translational modifications contributing to the activation and regulation of other proteins through cleavage.
- Biological function summary
Kallikrein 11 functions as a significant participant in seminal fluid production and sperm motility. It plays roles in maintenance and regulation of these physiological processes. Kallikrein 11 is part of the extensive kallikrein-related peptidase family; hence it shares functional characteristics with other serine proteases in this family. It contributes to the breaking down of extracellular matrix proteins implicating it in tissue remodeling.
- Pathways
Kallikrein 11 integrates into the kallikrein-kinin system and affects components involved in this biochemical network. This system impacts blood pressure regulation and inflammation processes. Kallikrein 11 acts in conjunction with other kallikreins and kinins leading to potential modulation of inflammatory responses and vascular functions. Its actions are related to pathways involving proteins such as prostatic acid phosphatase and prostate-specific antigen (PSA).
- Associated diseases and disorders
Kallikrein 11 has been implicated in prostate cancer and Alzheimer's disease. Increased expression of kallikrein 11 correlates with prostate cancer progression and serves as a potential biomarker for this condition. Additionally research suggests an association between aberrant kallikrein activity and Alzheimer's pathology though this involves more intricate enzymatic pathways with proteins like amyloid precursor protein (APP). Understanding its role in these diseases may offer new therapeutic avenues.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-Kallikrein 11 antibody (ab131038)
All lanes: Western blot - Anti-Kallikrein 11 antibody (ab131038) at 0.1 µg/mL
Lane 1: M231 cell lysate
Lane 2: M453 cell lysate
Lane 3: Jurkat cell lysate
Lane 4: COLO320 cell lysate
Lane 5: HT1080 cell lysate
Lane 6: COLO320 Cell Lysate
Lane 7: JURKAT Cell Lysate
Predicted band size: 31 kDa
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 11 antibody (ab131038)
Immunohistochemical analysis of paraffin-embedded Human prostatic cancer tissue labelling Kallikrein 11 with ab131038 at 0.5 μg/ml.
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