AB181402

Anti-Kallikrein 4 antibody

Name: Anti-Kallikrein 4 antibody (ab181402) | Abcam
Brand: Abcam Limited
SKU: AB181402

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(3 Publications )

Rabbit Polyclonal Kallikrein 4 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human KLK4.

View Alternative Names

EMSP1, PRSS17, PSTS, KLK4, Kallikrein-4, Enamel matrix serine proteinase 1, Kallikrein-like protein 1, Prostase, Serine protease 17, KLK-L1

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-Kallikrein 4 antibody (AB181402)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Kallikrein 4 antibody (AB181402)

Immunofluorescence analysis of Human kidney tissue, labeling Kallikrein 4 using ab181402 at 20 μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 4 antibody (AB181402)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 4 antibody (AB181402)

Immunohistochemical analysis of paraffin-embedded Human kidney tissue, labeling Kallikrein 4 using ab181402 at 5 μg/mL.

Supplier Data

Western blot - Anti-Kallikrein 4 antibody (AB181402)

All lanes:

Western blot - Anti-Kallikrein 4 antibody (ab181402) at 1 µg/mL

All lanes:

Human kidney tissue lysate at 15 µg

Predicted band size: 27 kDa

Observed band size: 31 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Synthetic Peptide within Human KLK4. The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5 µg/mL", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kallikrein 4 also known by the alternate name KLK4 is a serine protease enzyme with a molecular mass of approximately 30 kDa. This enzyme belongs to the kallikrein family which is a subset of the larger protease family. KLK4 is mainly expressed in the prostate teeth and skin. Its primary mechanical function involves cleaving peptide bonds in proteins contributing to protein degradation and activation of other proteins.

Biological function summary

KLK4 plays a significant role in the remodeling of extracellular matrix components. It is particularly involved in dentin matrix degradation during tooth development where it contributes to enamel formation and maturation. Although not part of a larger protein complex KLK4 works in conjunction with enzymes like KLK1 and KLK3 to regulate various biological processes through proteolytic action.

Pathways

The activity of KLK4 integrates into the kallikrein-kinin system and the broader ECM degradation pathway. Within the kallikrein-kinin system KLK4 functions alongside proteins like KLK1 to influence vasodilation and inflammation. In the ECM degradation pathway KLK4 contributes to matrix remodeling by breaking down structural proteins facilitating physiological processes like tissue repair and cancer metastasis.

KLK4 has connections with prostate cancer and amelogenesis imperfecta. In prostate cancer aberrant expression of KLK4 might contribute to tumor progression associating with prostate-specific antigen (PSA) also known as KLK3. In amelogenesis imperfecta mutations in the KLK4 gene can impair enamel formation emphasizing its role in tooth integrity and formation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Has a major role in enamel formation (PubMed : 15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).

See full target information KLK4

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Molecular therapy : the journal of the American Society of Gene Therapy 31:193-210 PubMed36146932

2022

NAMPT is a metabolic checkpoint of IFNγ-producing CD4 T cells in lupus nephritis.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyuan Li,Yimei Lai,Binfeng Chen,Chaohuan Guo,Mianjing Zhou,Siyuan Zhao,Shuyi Wang,Jin Li,Niansheng Yang,Hui Zhang

Science advances 7: PubMed33627420

2021

Islet expression of type I interferon response sensors is associated with immune infiltration and viral infection in type 1 diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Paola S Apaolaza,Diana Balcacean,Jose Zapardiel-Gonzalo,Grace Nelson,Nataliya Lenchik,Pouria Akhbari,Ivan Gerling,Sarah J Richardson,Teresa Rodriguez-Calvo

Cancer management and research 12:2753-2765 PubMed32425594

2020

Circular RNA Circ_0025033 Promotes the Evolvement of Ovarian Cancer Through the Regulation of miR-330-5p/KLK4 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Hailing Cheng,Ning Wang,Jun Tian,Yanyun Li,Lu Ren,Zhenyu Shi

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Kallikrein 4 antibody

Immunocytochemistry/ Immunofluorescence - Anti-Kallikrein 4 antibody (AB181402)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 4 antibody (AB181402)

Western blot - Anti-Kallikrein 4 antibody (AB181402)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

Product promise