AB197657

Anti-Kallikrein 4 antibody

Name: Anti-Kallikrein 4 antibody (ab197657) | Abcam
Brand: Abcam Limited
SKU: AB197657
Price: 535 USD
Availability: InStock

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(2 Publications)

Rabbit Polyclonal Kallikrein 4 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KLK4.

View Alternative Names

EMSP1, PRSS17, PSTS, KLK4, Kallikrein-4, Enamel matrix serine proteinase 1, Kallikrein-like protein 1, Prostase, Serine protease 17, KLK-L1

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 4 antibody (AB197657)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 4 antibody (AB197657)

Immunohistochemical analysis of paraffin-embedded Human cervical cancer tissue labeling Kallikrein 4 using ab197657 at a 1/15 dilution.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 4 antibody (AB197657)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling Kallikrein 4 using ab197657 at a 1/15 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KLK4. The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/15 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kallikrein 4 also known by the alternate name KLK4 is a serine protease enzyme with a molecular mass of approximately 30 kDa. This enzyme belongs to the kallikrein family which is a subset of the larger protease family. KLK4 is mainly expressed in the prostate teeth and skin. Its primary mechanical function involves cleaving peptide bonds in proteins contributing to protein degradation and activation of other proteins.

Biological function summary

KLK4 plays a significant role in the remodeling of extracellular matrix components. It is particularly involved in dentin matrix degradation during tooth development where it contributes to enamel formation and maturation. Although not part of a larger protein complex KLK4 works in conjunction with enzymes like KLK1 and KLK3 to regulate various biological processes through proteolytic action.

Pathways

The activity of KLK4 integrates into the kallikrein-kinin system and the broader ECM degradation pathway. Within the kallikrein-kinin system KLK4 functions alongside proteins like KLK1 to influence vasodilation and inflammation. In the ECM degradation pathway KLK4 contributes to matrix remodeling by breaking down structural proteins facilitating physiological processes like tissue repair and cancer metastasis.

KLK4 has connections with prostate cancer and amelogenesis imperfecta. In prostate cancer aberrant expression of KLK4 might contribute to tumor progression associating with prostate-specific antigen (PSA) also known as KLK3. In amelogenesis imperfecta mutations in the KLK4 gene can impair enamel formation emphasizing its role in tooth integrity and formation.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
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Target data

Has a major role in enamel formation (PubMed : 15235027). Required during the maturation stage of tooth development for clearance of enamel proteins and normal structural patterning of the crystalline matrix (By similarity).

See full target information KLK4

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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular medicine 46:179-190 PubMed32626909

2020

Effects of applying amoxicillin in juvenile mice on enamel mineralization and the expression of kallikrein‑related peptidase 4 and tight junction proteins in ameloblasts.

Applications

Unspecified application

Species

Unspecified reactive species

Jianghong Gao,Xinmei Li,Liping Gao,Haiyan Chen,Bashayer H Baras,Xiaojing Liu,Hao Liu,Ayesha Rana,Meili Gao,Jianping Ruan

Journal of gastroenterology and hepatology 34:1851-1859 PubMed30884543

2019

Establishment of gene-edited pigs expressing human blood-coagulation factor VII and albumin for bioartificial liver use.

Applications

Unspecified application

Species

Unspecified reactive species

Li Li,Hongyi Meng,Qingjian Zou,Jianmin Zhang,Lei Cai,Bin Yang,Jun Weng,Liangxue Lai,Huaqiang Yang,Yi Gao

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Kallikrein 4 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 4 antibody (AB197657)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 4 antibody (AB197657)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

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Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (2)

Product promise