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AB176299

Anti-Kallikrein 5 antibody

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(4 Publications)

Rabbit Polyclonal Kallikrein 5 antibody. Suitable for WB and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KLK5 aa 1-200.

View Alternative Names

SCTE, UNQ570/PRO1132, KLK5, Kallikrein-5, Kallikrein-like protein 2, Stratum corneum tryptic enzyme, KLK-L2

1 Images
Western blot - Anti-Kallikrein 5 antibody (AB176299)
  • WB

Supplier Data

Western blot - Anti-Kallikrein 5 antibody (AB176299)

All lanes:

Western blot - Anti-Kallikrein 5 antibody (ab176299) at 1/500 dilution

All lanes:

Mouse brain tissue lysate

Predicted band size: 32 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human KLK5 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.

Q9Y337

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kallikrein 5 also known as KLK5 or stratum corneum tryptic enzyme is a serine protease enzyme with a molecular weight of approximately 30 kDa. It is encoded by the KLK5 gene and is part of the kallikrein family. KLK5 is mainly expressed in the skin but also found in other tissues such as the esophagus and breast. The enzyme plays a mechanical role in skin barrier function by processing and activating other kallikreins catalyzing the degradation of corneodesmosomes which are essential for skin desquamation.
Biological function summary

KLK5 assists in maintaining the skin's outermost layer by regulating the desquamation process. It does not operate in isolation but is an intrinsic part of the kallikrein proteolytic cascade which involves several other kallikrein-related peptidases including KLK7 and KLK14. This cascade ensures proper turnover and shedding of damaged or mature cells from the skin surface playing an important role in skin homeostasis and renewal. It is significant in forming a protective barrier against environmental insults.

Pathways

KLK5 integrates into the skin barrier and inflammation regulation pathways. Its activity influences the activation of other proteases and signaling molecules involved in skin inflammation and repair processes. Related proteins like protease-activated receptors (PARs) interact with KLK5 mediating downstream signaling that impacts inflammation and tissue remodeling. The cascades involving KLK5 serve as checkpoints in cutaneous homeostasis and immune responses.

KLK5 has an important association with skin conditions like atopic dermatitis and Netherton syndrome. In atopic dermatitis abnormal KLK5 expression leads to compromised skin barrier integrity exacerbating the condition. It also relates to LEKTI (lympho-epithelial Kazal-type related inhibitor) dysfunction in Netherton syndrome where uncontrolled KLK5 activity contributes to severe barrier defects. The interactions between KLK5 and these disorders highlight its role in pathophysiological processes affecting skin health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

May be involved in desquamation.
See full target information KLK5
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Gland surgery 14:1456-1472 PubMed40948916

2025

Identification and validation of a novel lymph node metastasis-related model for papillary thyroid carcinoma to predict the prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Chao-Ran Xie,Xi-Wei Zhang,Qi Chen,Li-Feng Zhao,Kai-Ming Huang,Yong Wang,Xing Yu

Cancer innovation 2:376-390 PubMed38090381

2023

Bioinformatics analysis of human kallikrein 5 () expression in metaplastic triple-negative breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yue Song,Guiying Bai,Xiaoqing Li,Liyan Zhou,Yiran Si,Xiaohui Liu,Yilin Deng,Yehui Shi

Experimental dermatology 31:223-232 PubMed34378233

2021

STAT3 maintains skin barrier integrity by modulating SPINK5 and KLK5 expression in keratinocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Jaehyung Kim,Min-Gyu Kim,Sang Hoon Jeong,Hee Joo Kim,Sang Wook Son

International journal of molecular sciences 21: PubMed32630820

2020

Effects of DSPP and MMP20 Silencing on Adhesion, Metastasis, Angiogenesis, and Epithelial-Mesenchymal Transition Proteins in Oral Squamous Cell Carcinoma Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Jaya Aseervatham,Kalu U E Ogbureke
View all publications
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