AB190924

Anti-Kallikrein 6 antibody - C-terminal

Name: Anti-Kallikrein 6 antibody - C-terminal (ab190924) | Abcam
Brand: Abcam Limited
SKU: AB190924
Price: 545 USD
Availability: InStock

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(3 Publications)

Rabbit Polyclonal Kallikrein 6 antibody. C-terminal. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human KLK6 aa 200 to C-terminus.

View Alternative Names

PRSS18, PRSS9, KLK6, Kallikrein-6, Neurosin, Protease M, SP59, Serine protease 18, Serine protease 9, Zyme

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-Kallikrein 6 antibody - C-terminal (AB190924)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Kallikrein 6 antibody - C-terminal (AB190924)

Immunocytochemical analysis of PC3 cells labeling Kallikrein 6 using ab190924 at 1 μg/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 6 antibody - C-terminal (AB190924)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 6 antibody - C-terminal (AB190924)

Immunohistochemical analysis of formalin fixed paraffin-embedded Human intestinal cancer tissue labeling Kallikrein 6 using ab190924 at 1 μg/ml.

Supplier Data

Western blot - Anti-Kallikrein 6 antibody - C-terminal (AB190924)

All lanes:

Western blot - Anti-Kallikrein 6 antibody - C-terminal (ab190924) at 0.5 µg/mL

Lane 1:

MCF-7 whole cell lysate at 40 µg

Lane 2:

HeLa whole cell lysate at 40 µg

Lane 3:

MM 231 whole cell lysate at 40 µg

Lane 4:

MM 453 whole cell lysate at 40 µg

Lane 5:

A549 whole cell lysate at 40 µg

Lane 6:

SMMC whole cell lysate at 40 µg

Lane 7:

COLO320 whole cell lysate at 40 µg

Lane 8:

SW620 whole cell lysate at 40 µg

Lane 9:

HT1080 whole cell lysate at 40 µg

Predicted band size: 27 kDa

Observed band size: 27 kDa

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Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Synthetic Peptide within Human KLK6 aa 200 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q92876

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "0.5-1 µg/mL", "IHCP-species-notes": " Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.5 µg/mL", "WB-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.5-1 µg/mL", "ICCIF-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

Preservative: 0.025% Sodium azide, 0.025% Thimerosal (merthiolate) Constituents: 2.5% BSA, 0.45% Sodium chloride, 0.1% Disodium hydrogenorthophosphate

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kallikrein 6 also known as KLK6 is a serine protease with notable enzymatic properties. This protein part of the kallikrein family weighs approximately 25 kDa and exhibits chymotrypsin-like activity. KLK6 is highly expressed in the central nervous system and various body fluids such as cerebrospinal fluid and milk. Due to this distribution KLK6 may play roles in neurological and physiological processes.

Biological function summary

KLK6 participates in the degradation of extracellular matrix components. It functions within complex proteolytic cascades facilitating tissue remodeling and repair. Additionally KLK6 interacts with other kallikreins like kallikrein 3 showing intricate regulation within the kallikrein-related peptidase network. This interplay points toward its importance in modulating extracellular environment and cellular interactions.

Pathways

KLK6 engages in the neurogenic and inflammatory response pathways. It ties into MAPK signaling influencing processes such as cell proliferation and apoptosis. Through these pathways KLK6 associates with proteins like MMPs which modulate extracellular matrix dynamics. Its presence in these pathways positions KLK6 as a significant regulatory protein during cellular homeostasis and stress responses.

KLK6 correlates with neurodegenerative diseases like Alzheimer's and multiple sclerosis. Altered expression and activity levels of KLK6 have implications for disease progression and pathology. In Alzheimer's KLK6 may influence amyloid-beta processing connecting with proteins like APP. In multiple sclerosis KLK6 affects demyelination processes showing potential interactions with myelin-associated proteins. Understanding these relationships can guide therapeutic strategies targeting KLK6-related pathways.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis.

See full target information KLK6

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Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 8:1387 PubMed41028816

2025

Uncovering a fibroblast differentiation-based keloid classification by integration of single-cell and bulk RNA sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Wei Zhang,Jianyu Lu,Xirui Tong,Sujie Xie,Shuyuan Xian,Yifan Liu,Jiale Yan,Weijin Qian,Hanlin Sun,Yushu Zhu,Luofeng Jiang,Xinya Guo,Xinran Ding,Yixu Li,Chenguang Bai,Runzhi Huang,Zhaofan Xia,Shizhao Ji

Matrix biology plus 6-7:100019 PubMed33543017

2019

Kallikreins: Essential epidermal messengers for regulation of the skin microenvironment during homeostasis, repair and disease.

Applications

Unspecified application

Species

Unspecified reactive species

Pauline Nauroy,Alexander Nyström

Journal of gastric cancer 18:356-367 PubMed30607299

2018

KLK6 Promotes Growth, Migration, and Invasion of Gastric Cancer Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Shengxing Zhu,Jihua Shi,Shanfeng Zhang,Zhen Li

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Kallikrein 6 antibody - C-terminal

Immunocytochemistry/ Immunofluorescence - Anti-Kallikrein 6 antibody - C-terminal (AB190924)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kallikrein 6 antibody - C-terminal (AB190924)

Western blot - Anti-Kallikrein 6 antibody - C-terminal (AB190924)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (3)

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