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AB187656

Anti-Kallistatin/PI-4 antibody [EPR15310]

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(4 Publications)

Rabbit Recombinant Monoclonal Kallistatin/PI-4 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications.

View Alternative Names

KST, PI4, SERPINA4, Kallistatin, Kallikrein inhibitor, Peptidase inhibitor 4, Serpin A4, PI-4

1 Images
Western blot - Anti-Kallistatin/PI-4 antibody [EPR15310] (AB187656)
  • WB

Supplier Data

Western blot - Anti-Kallistatin/PI-4 antibody [EPR15310] (AB187656)

All lanes:

Western blot - Anti-Kallistatin/PI-4 antibody [EPR15310] (ab187656) at 1/1000 dilution

All lanes:

Human plasma lysate at 20 µg

Secondary

All lanes:

Anti-Rabbit IgG (HRP), specific to the non-reduced form of IgG at 1/1000 dilution

Predicted band size: 49 kDa

Observed band size: 49 kDa

true

  • Carrier free

    Anti-Kallistatin/PI-4 antibody [EPR15310] - BSA and Azide free

Key facts

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR15310

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Product details

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kallistatin also known as PI-4 is a serine proteinase inhibitor with a mass of approximately 52 kDa. You find it mainly in the liver as part of the serpin superfamily. This protein acts mechanically by inhibiting the tissue kallikrein-kinin system which involves proteolytic processes that regulate vascular homeostasis and blood pressure. In addition to the liver kallistatin is expressed in endothelial cells and various human tissues.
Biological function summary

Kallistatin participates in inhibiting angiogenesis and inflammation impacting cellular behavior and responses. As a serpin it functions uniquely in forming stable complexes with target enzymes like tissue kallikrein. Through this mechanism kallistatin contributes to maintaining vascular integrity and preventing excessive vascular growth or inflammation that could lead to pathology.

Pathways

The inhibitory effects of kallistatin integrate into the kallikrein-kinin system and the renin-angiotensin system. In the kallikrein-kinin system kallistatin regulates processes involving vascular tone and fluid balance. It interacts with proteins such as bradykinin mediating inflammatory responses and endothelial cell function through these key pathways.

Researchers link kallistatin with conditions like hypertension and cancer. Its role in inhibiting angiogenesis and inflammation helps understand its protective effects against tumor growth and metastasis. In hypertension kallistatin's relationship with the renin-angiotensin system connects it to other proteins like angiotensin II influencing blood pressure regulation and vascular health.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Inhibits human amidolytic and kininogenase activities of tissue kallikrein. Inhibition is achieved by formation of an equimolar, heat- and SDS-stable complex between the inhibitor and the enzyme, and generation of a small C-terminal fragment of the inhibitor due to cleavage at the reactive site by tissue kallikrein.
See full target information SERPINA4
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

eLife 13: PubMed40762561

2025

The novel role of Kallistatin in linking metabolic syndromes and cognitive memory deterioration by inducing amyloid-β plaques accumulation and tau protein hyperphosphorylation.

Applications

Unspecified application

Species

Unspecified reactive species

Weiwei Qi,Yanlan Long,Ziming Li,Zhen Zhao,Jinhui Shi,Wanting Xie,Laijian Wang,Yandan Tan,Ti Zhou,Minting Liang,Ping Jiang,Bin Jiang,Xia Yang,Guoquan Gao

Journal of cellular and molecular medicine 26:4613-4623 PubMed35866203

2022

Kallistatin prevents ovarian hyperstimulation syndrome by regulating vascular leakage.

Applications

Unspecified application

Species

Unspecified reactive species

Jianfang Huang,Yuling Mao,Quanxin Li,Honghai Hong,Ni Tang,Xiangjin Kang,Yuling Huang,Jianqiao Liu,Qing Gong,Yachao Yao,Lei Li

Diabetes 71:747-761 PubMed35044447

2022

Pathogenic Role of Diabetes-Induced Overexpression of Kallistatin in Corneal Wound Healing Deficiency Through Inhibition of Canonical Wnt Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Wentao Liang,Li Huang,Xiang Ma,Lijie Dong,Rui Cheng,Marcus Dehdarani,Dimitrios Karamichos,Jian-Xing Ma

The Journal of cell biology 220: PubMed33861319

2021

FIT2 organizes lipid droplet biogenesis with ER tubule-forming proteins and septins.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Chen,Bing Yan,Jie Ren,Rui Lyu,Yanfang Wu,Yuting Guo,Dong Li,Hong Zhang,Junjie Hu
View all publications
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Product promise

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