JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB121410

Anti-KANK4 antibody

Be the first to review this product! Submit a review

|

(3 Publications)

Rabbit Polyclonal KANK4 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KANK4 aa 350-550.

View Alternative Names

ANKRD38, KANK4, KN motif and ankyrin repeat domain-containing protein 4, Ankyrin repeat domain-containing protein 38

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KANK4 antibody (AB121410)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KANK4 antibody (AB121410)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placenta tissue labelling KANK4 with ab121410 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KANK4 antibody (AB121410)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KANK4 antibody (AB121410)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling KANK4 with ab121410 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KANK4 antibody (AB121410)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KANK4 antibody (AB121410)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human kidney tissue labelling KANK4 with ab121410 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KANK4 antibody (AB121410)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KANK4 antibody (AB121410)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pancreas tissue labelling KANK4 with ab121410 at 1/50 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Western blot - Anti-KANK4 antibody (AB121410)
  • WB

Unknown

Western blot - Anti-KANK4 antibody (AB121410)

All lanes:

Western blot - Anti-KANK4 antibody (ab121410) at 0.4 µg/mL

All lanes:

Human Placenta Tissue

Predicted band size: 107 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human KANK4 aa 350-550. The exact immunogen used to generate this antibody is proprietary information.

Q5T7N3

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KANK4 also referred to as KN motif and ankyrin repeat domain-containing protein 4 is a protein that plays an important role in cellular functions. It has a molecular mass of approximately 45 kDa. This protein is expressed in various tissues with notable levels in the kidney and brain. Its presence in these tissues suggests a significant role in cellular structural maintenance and signaling processes. KANK4 contributes to the organization of the cytoskeleton and participates in cellular adhesion.
Biological function summary

KANK4 functions as a scaffolding protein that connects other proteins to the cytoskeleton aiding in maintaining cell shape and motility. It is a part of a larger protein complex that includes elements involved in actin filament assembly. This functional role is important for cellular responses to external stimuli and mechanical stress. KANK4's interaction with such protein complexes can influence cell motility and structural integrity reflecting its versatility in multiple biological contexts.

Pathways

KANK4 integrates into pathways like the Rho GTPase signaling pathway which is vital for cytoskeletal rearrangement and cell movement. It is associated with actin-binding proteins and Rho-associated coiled-coil containing protein kinase (ROCK) indicating its role in signal transduction and changes in cell shape. These pathways highlight KANK4’s involvement in cellular dynamics and its influence on other proteins related to cytoskeletal functions.

KANK4 has associations with kidney diseases particularly those involving impaired glomerular function. Alterations or dysregulation in KANK4 can disrupt cellular architecture impacting kidney function and leading to pathological states. Additionally deficiencies in KANK4 expression have been linked to neurodevelopmental disorders due to its interactions with proteins like Ankyrin which is essential for neuronal connectivity and stability. These connections indicate the potential impact of KANK4 in specific tissues and highlight its significance in health and disease.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

May be involved in the control of cytoskeleton formation by regulating actin polymerization.
See full target information KANK4
style
left-column

Publications (3)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 14:8725 PubMed38622256

2024

Exclusive expression of KANK4 promotes myofibroblast mobility in keloid tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Mayumi Oishi,Keiko Shinjo,Keisuke Takanari,Ayako Muraoka,Miho M Suzuki,Miki Kanbe,Shinichi Higuchi,Katsumi Ebisawa,Kazunobu Hashikawa,Yuzuru Kamei,Yutaka Kondo

Mechanisms of ageing and development 177:157-181 PubMed29913199

2018

Genome-wide profiling of adult human papillary and reticular fibroblasts identifies ACAN, Col XI α1, and PSG1 as general biomarkers of dermis ageing, and KANK4 as an exemplary effector of papillary fibroblast ageing, related to contractility.

Applications

Unspecified application

Species

Unspecified reactive species

Valérie Haydont,Véronique Neiveyans,Hélène Zucchi,Nicolas O Fortunel,Daniel Asselineau

Nature communications 8:14898 PubMed28358029

2017

Genome-wide association study identifies three novel loci in Fuchs endothelial corneal dystrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Natalie A Afshari,Robert P Igo,Nathan J Morris,Dwight Stambolian,Shiwani Sharma,V Lakshmi Pulagam,Steven Dunn,John F Stamler,Barbara J Truitt,Jacqueline Rimmler,Abraham Kuot,Christopher R Croasdale,Xuejun Qin,Kathryn P Burdon,S Amer Riazuddin,Richard Mills,Sonja Klebe,Mollie A Minear,Jiagang Zhao,Elmer Balajonda,George O Rosenwasser,Keith H Baratz,V Vinod Mootha,Sanjay V Patel,Simon G Gregory,Joan E Bailey-Wilson,Marianne O Price,Francis W Price,Jamie E Craig,John H Fingert,John D Gottsch,Anthony J Aldave,Gordon K Klintworth,Jonathan H Lass,Yi-Ju Li,Sudha K Iyengar
View all publications
style
left-column
style
left-column
style
right-column

Complementary Products

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB121927

Anti-UBE3D antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-UBE3D antibody (AB121927)

  • 5
  • 1
Primary Antibodies

AB121677

Anti-SVEP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SVEP1 antibody (AB121677)

  • 0
  • 1
Primary Antibodies

AB121425

Anti-OPALIN antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-OPALIN antibody (AB121425)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com