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Mouse Polyclonal Kappa Opioid Receptor antibody. N-terminal. Suitable for WB and reacts with Rat, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human OPRK1 aa 1-100.

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Images

Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (AB194371), expandable thumbnail
  • Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (AB194371), expandable thumbnail
  • Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (AB194371), expandable thumbnail

Key facts

Isotype

IgG

Host species

Mouse

Storage buffer

Constituents: 50% Glycerol (glycerin, glycerine)

Form

Liquid

Clonality

Polyclonal

Immunogen

  • Recombinant Fragment Protein within Human OPRK1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link P41145

Reactivity data

Select an application
Product promiseTestedExpectedPredictedNot recommended
WB
Human
Tested
Rat
Tested

Tested
Tested

Species

Rat

Dilution info

1/500 - 1/1000

Notes

-

Species

Human

Dilution info

1/500 - 1/1000

Notes

-

Associated Products

Select an associated product type

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Target data

Function

G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.

Alternative names

Recommended products

Mouse Polyclonal Kappa Opioid Receptor antibody. N-terminal. Suitable for WB and reacts with Rat, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human OPRK1 aa 1-100.

Key facts

Isotype

IgG

Form

Liquid

Clonality

Polyclonal

Immunogen
  • Recombinant Fragment Protein within Human OPRK1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information. Database link P41145
Purity

Whole antiserum

Concentration
Loading...

Storage

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

Notes

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

The Kappa Opioid Receptor also known as KOR or kappa receptors is a type of opioid receptor that plays an important role in the nervous system. It is a protein with an approximate mass of 43 kDa. This receptor mainly expresses in the human brain especially in regions involved in pain and stress responses such as the hypothalamus and thalamus. Kappa receptors are involved in modulating neurotransmitter release and can affect synaptic transmission.

Biological function summary

Kappa opioid receptors mediate pain perception mood regulation and stress response. They form part of a larger receptor family the G-protein coupled receptors (GPCRs) which are critical in cellular signaling. Activation of these receptors can produce analgesic effects differing from other opioid receptors due to their unique mechanism of action. Kappa receptors interact with endogenous ligands called dynorphins which are peptide neurotransmitters involved in natural pain relief processes.

Pathways

Kappa opioid receptors are integral to the dopaminergic and serotonergic pathways. In the dopaminergic pathway kappa receptors reduce dopamine release influencing the reward system and potentially affecting addiction behaviors. In the serotonergic pathway they modulate serotonin levels connecting to mood and anxiety regulation. These pathways also involve proteins like the mu-opioid receptor and delta-opioid receptor which along with kappa receptors form a complex regulatory network.

Associated diseases and disorders

Kappa opioid receptors have been linked to depression and drug addiction. In depression dysfunctional kappa receptor activity may disrupt mood regulation contributing to depressive symptoms. The associated protein dynorphin plays a role in this condition by interacting with kappa receptors. In drug addiction these receptors influence the brain's reward circuits impacting addiction severity through altered dopamine signaling. Understanding kappa receptors can offer insights into new therapeutic approaches for these conditions.

Product promise

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3 product images

  • Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371), expandable thumbnail

    Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371)

    All lanes: Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371) at 1/500 dilution

    All lanes: Rat kidney tissue lysate at 50 µg

    Developed using the ECL technique.

    Predicted band size: 42 kDa

  • Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371), expandable thumbnail

    Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371)

    All lanes: Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371) at 1/500 dilution

    All lanes: Human ovarian cancer tissue lysate at 50 µg

    Developed using the ECL technique.

    Predicted band size: 42 kDa

  • Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371), expandable thumbnail

    Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371)

    Predicted MWt of immunogen: 32.49 KDa.

    All lanes: Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371) at 1/1000 dilution

    All lanes: recombinant Human Kappa Opioid Receptor protein (immunogen) at 0.2 µg

    Developed using the ECL technique.

    Predicted band size: 42 kDa

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can:

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