Mouse Polyclonal Kappa Opioid Receptor antibody. N-terminal. Suitable for WB and reacts with Rat, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human OPRK1 aa 1-100.
IgG
Mouse
Constituents: 50% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
WB | |
---|---|
Human | Tested |
Rat | Tested |
Species | Dilution info | Notes |
---|---|---|
Species Rat | Dilution info 1/500 - 1/1000 | Notes - |
Species Human | Dilution info 1/500 - 1/1000 | Notes - |
Select an associated product type
G-protein coupled opioid receptor that functions as a receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as a receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
OPRK, OPRK, OPRK1, Kappa-type opioid receptor, K-OR-1, KOR-1
Mouse Polyclonal Kappa Opioid Receptor antibody. N-terminal. Suitable for WB and reacts with Rat, Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human OPRK1 aa 1-100.
IgG
Mouse
Constituents: 50% Glycerol (glycerin, glycerine)
Liquid
Polyclonal
Whole antiserum
Blue Ice
1-2 weeks
+4°C
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
The Kappa Opioid Receptor also known as KOR or kappa receptors is a type of opioid receptor that plays an important role in the nervous system. It is a protein with an approximate mass of 43 kDa. This receptor mainly expresses in the human brain especially in regions involved in pain and stress responses such as the hypothalamus and thalamus. Kappa receptors are involved in modulating neurotransmitter release and can affect synaptic transmission.
Kappa opioid receptors mediate pain perception mood regulation and stress response. They form part of a larger receptor family the G-protein coupled receptors (GPCRs) which are critical in cellular signaling. Activation of these receptors can produce analgesic effects differing from other opioid receptors due to their unique mechanism of action. Kappa receptors interact with endogenous ligands called dynorphins which are peptide neurotransmitters involved in natural pain relief processes.
Kappa opioid receptors are integral to the dopaminergic and serotonergic pathways. In the dopaminergic pathway kappa receptors reduce dopamine release influencing the reward system and potentially affecting addiction behaviors. In the serotonergic pathway they modulate serotonin levels connecting to mood and anxiety regulation. These pathways also involve proteins like the mu-opioid receptor and delta-opioid receptor which along with kappa receptors form a complex regulatory network.
Kappa opioid receptors have been linked to depression and drug addiction. In depression dysfunctional kappa receptor activity may disrupt mood regulation contributing to depressive symptoms. The associated protein dynorphin plays a role in this condition by interacting with kappa receptors. In drug addiction these receptors influence the brain's reward circuits impacting addiction severity through altered dopamine signaling. Understanding kappa receptors can offer insights into new therapeutic approaches for these conditions.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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All lanes: Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371) at 1/500 dilution
All lanes: Rat kidney tissue lysate at 50 µg
Developed using the ECL technique.
Predicted band size: 42 kDa
All lanes: Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371) at 1/500 dilution
All lanes: Human ovarian cancer tissue lysate at 50 µg
Developed using the ECL technique.
Predicted band size: 42 kDa
Predicted MWt of immunogen: 32.49 KDa.
All lanes: Western blot - Anti-Kappa Opioid Receptor antibody - N-terminal (ab194371) at 1/1000 dilution
All lanes: recombinant Human Kappa Opioid Receptor protein (immunogen) at 0.2 µg
Developed using the ECL technique.
Predicted band size: 42 kDa
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