Anti-Kaptin antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

Kaptin also known as KPTN is an actin-binding protein with a molecular weight of approximately 45 kDa. It plays an important mechanical role in the regulation of actin cytoskeleton dynamics. Kaptin localizes to cellular structures where actin remodeling occurs such as the tips of filopodia and lamellipodia. It expresses widely but shows increased presence in neuronal tissues where active cytoskeletal rearrangements take place.

Biological function summary

Kaptin acts in cellular processes requiring actin filament regulation. It is a part of the complex interacting with actin influencing cellular movement shape and signal transduction. By binding actin Kaptin promotes changes in cell motility and is particularly important in neuronal cells where rapid restructuring is needed for functions like synaptic signaling and plasticity.

Pathways

Kaptin plays a role in the regulation of the actin cytoskeleton pathway which is critical for cell movement and signaling. It interacts with proteins such as profilin and gelsolin which also modulate actin dynamics. Its involvement is vital in pathways facilitating cell motility and growth cone guidance in neurons showing its importance in maintaining cellular architecture and communication.

Associated diseases and disorders

Scientists relate Kaptin to neurological conditions and sensory impairments. Mutations in the KPTN gene associate with conditions like intellectual disability and cortical malformations. Kaptin's connectivity with actin and related proteins such as cofilin highlights its potential impact on disease when dysregulated influencing neuronal development and function.