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AB89608

Anti-KAT2/AadAT antibody

5

(2 Reviews)

|

(2 Publications)

Mouse Polyclonal KAT2/AadAT antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 2 publications.

View Alternative Names

KAT2, KYAT2, AADAT, KAT/AadAT, 2-aminoadipate aminotransferase, 2-aminoadipate transaminase, Alpha-aminoadipate aminotransferase, Glycine transaminase AADAT, Kynurenine aminotransferase II, Kynurenine--glyoxylate transaminase AADAT, Kynurenine--oxoglutarate aminotransferase II, Kynurenine--oxoglutarate transaminase 2, Kynurenine--oxoglutarate transaminase II, Methionine--glyoxylate transaminase AADAT, AadAT

2 Images
Western blot - Anti-KAT2/AadAT antibody (AB89608)
  • WB

Unknown

Western blot - Anti-KAT2/AadAT antibody (AB89608)

All lanes:

Western blot - Anti-KAT2/AadAT antibody (ab89608) at 1 µg/mL

All lanes:

Human liver lysate at 50 µg

Predicted band size: 47 kDa

Observed band size: 44 kDa

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Western blot - Anti-KAT2/AadAT antibody (AB89608)
  • WB

Unknown

Western blot - Anti-KAT2/AadAT antibody (AB89608)

All lanes:

Western blot - Anti-KAT2/AadAT antibody (ab89608) at 1 µg/mL

Lane 1:

KAT2/AadAT transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Predicted band size: 47 kDa

Observed band size: 42 kDa

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Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Alternative Products

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AB254661

Anti-KAT2/AadAT antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KAT2/AadAT antibody (AB254661)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KAT2 also known as AadAT is an important lysine acetyltransferase enzyme that modifies proteins by adding acetyl groups to lysine residues. This process impacts several cellular functions. KAT2 typically features a molecular mass of approximately 55 kDa. You will usually find it expressed in a wide range of tissues including liver and brain. The enzyme's presence suggests an essential role in numerous physiological processes particularly within the nucleus where it modifies histones.
Biological function summary

KAT2/AadAT takes part in chromatin remodeling and gene expression regulation. This enzyme often functions as part of multiprotein complexes which include transcription factors and coactivators. The acetylation of histone proteins by KAT2 modifies chromatin structure resulting in enhanced access of transcription machinery to DNA. This activity is essential for processes like cell growth and differentiation playing a significant role in maintaining normal physiological conditions.

Pathways

KAT2/AadAT is integrated into the larger network of acetylation-mediated gene regulation. Two primary pathways it is involved with include the gene expression pathway and the chromatin modification pathway. In these pathways KAT2 interacts with proteins such as CBP/p300 which act as transcriptional coactivators. This interaction helps facilitate the acetylation process that is vital for gene activation and the subsequent biological responses to external stimuli.

Alterations in KAT2/AadAT activity link to specific conditions including cancer and neurodegenerative diseases. For instance abnormal KAT2 activity has been observed in certain cancers where dysregulated gene expression promotes tumor progression. Additionally altered acetylation patterns by KAT2 can contribute to neurodegenerative disorders where the modified interaction with proteins like HDAC1 disrupts normal neuronal function.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).
See full target information AADAT
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

International journal of molecular sciences 25: PubMed39000602

2024

Inhibition of Indoleamine 2,3-Dioxygenase Exerts Antidepressant-like Effects through Distinct Pathways in Prelimbic and Infralimbic Cortices in Rats under Intracerebroventricular Injection with Streptozotocin.

Applications

Unspecified application

Species

Unspecified reactive species

Yu Qin,Xiao Hu,Hui-Ling Zhao,Nurhumar Kurban,Xi Chen,Jing-Kun Yi,Yuan Zhang,Su-Ying Cui,Yong-He Zhang

Journal of the American Heart Association 12:e027769 PubMed36802924

2023

Role of PARP and TRPM2 in VEGF Inhibitor-Induced Vascular Dysfunction.

Applications

Unspecified application

Species

Unspecified reactive species

Karla B Neves,Rheure Alves-Lopes,Augusto C Montezano,Rhian M Touyz
View all publications
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Product promise

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