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AB82422

Anti-KATNAL1 antibody

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(1 Publication)

Rabbit Polyclonal KATNAL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KATNAL1.

View Alternative Names

Katanin p60 ATPase-containing subunit A-like 1, Katanin p60 subunit A-like 1, p60 katanin-like 1, KATNAL1

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human KATNAL1. The exact immunogen used to generate this antibody is proprietary information.

Q9BW62

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Reactivity data

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Product details

Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.

If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.

Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.

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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KATNAL1 also known as Katanin p60 subunit A1-like 1 acts as a microtubule-severing enzyme. This protein has a molecular mass of roughly 54 kDa. Microtubule severing is essential for regulating microtubule dynamics in cells. KATNAL1 is mainly expressed in testis and other tissues that require active microtubule rearrangement including brain and muscle tissues. Its activity helps modulate the cytoskeleton's architecture impacting cell division and intracellular transport.
Biological function summary

KATNAL1 controls microtubule length and organization in cellular environments. It is part of a larger complex involving microtubule-associated proteins which regulate assembly and disassembly of microtubules. The severing activity performed by KATNAL1 ensures proper cell cycle progression influencing spindle formation during mitosis and helping distribute organelles and proteins efficiently along cytoskeletal tracks.

Pathways

Several cellular processes require microtubule dynamics modulated by KATNAL1. One important pathway it is involved in is the regulation of the cell cycle where it interacts with proteins like tubulin for accurate chromosome segregation. In the neurological context its activity affects the establishment and maintenance of neuronal networks linking it to proteins such as stathmin which also influence microtubule stability.

KATNAL1's microtubule severing role has implications in fertility and neurodegenerative conditions. Disruption in its function results in abnormal spermatogenesis potentially leading to male infertility. In relation to neurological health KATNAL1's impairment may contribute to disorders characterized by defective neuronal morphology such as Alzheimer's disease. It connects with disease-associated proteins like tau a protein that stabilizes microtubules which accumulates abnormally in such disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed : 26929214).
See full target information KATNAL1
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of healthcare engineering 2022:4441603 PubMed35432831

2022

Impact of Yiqi Huoxue Decoction on the Relationship between Remodeling of Cardiac Nerves and Macrophages after Myocardial Infarction in Rats.

Applications

Unspecified application

Species

Unspecified reactive species

Yunke Liu,Shunwen Guo,Yuqin Zhang,Hui Wang,Jiani Wu,Wang'ou Lin,Binyue Zhang,Jie Chen,Yufei Li,Yunshu Zhang,Fanyu Wei,Tianhui Du
View all publications
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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