Rabbit Polyclonal KATNAL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KATNAL1.
IgG
Rabbit
Constituents: Whole serum
Liquid
Polyclonal
| WB | IHC-P | |
|---|---|---|
| Human | Expected | Expected |
| Mouse | Predicted | Predicted |
| Rat | Predicted | Predicted |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info Use at an assay dependent concentration. | Notes - |
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse, Rat | Dilution info - | Notes - |
Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays (By similarity). Has microtubule-severing activity in vitro (PubMed:26929214).
Katanin p60 ATPase-containing subunit A-like 1, Katanin p60 subunit A-like 1, p60 katanin-like 1, KATNAL1
Rabbit Polyclonal KATNAL1 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KATNAL1.
Katanin p60 ATPase-containing subunit A-like 1, Katanin p60 subunit A-like 1, p60 katanin-like 1, KATNAL1
IgG
Rabbit
Constituents: Whole serum
Liquid
Polyclonal
Whole antiserum
Blue Ice
-20°C
Upon delivery aliquot
Avoid freeze / thaw cycle
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This supplementary information is collated from multiple sources and compiled automatically.
KATNAL1 also known as Katanin p60 subunit A1-like 1 acts as a microtubule-severing enzyme. This protein has a molecular mass of roughly 54 kDa. Microtubule severing is essential for regulating microtubule dynamics in cells. KATNAL1 is mainly expressed in testis and other tissues that require active microtubule rearrangement including brain and muscle tissues. Its activity helps modulate the cytoskeleton's architecture impacting cell division and intracellular transport.
KATNAL1 controls microtubule length and organization in cellular environments. It is part of a larger complex involving microtubule-associated proteins which regulate assembly and disassembly of microtubules. The severing activity performed by KATNAL1 ensures proper cell cycle progression influencing spindle formation during mitosis and helping distribute organelles and proteins efficiently along cytoskeletal tracks.
Several cellular processes require microtubule dynamics modulated by KATNAL1. One important pathway it is involved in is the regulation of the cell cycle where it interacts with proteins like tubulin for accurate chromosome segregation. In the neurological context its activity affects the establishment and maintenance of neuronal networks linking it to proteins such as stathmin which also influence microtubule stability.
KATNAL1's microtubule severing role has implications in fertility and neurodegenerative conditions. Disruption in its function results in abnormal spermatogenesis potentially leading to male infertility. In relation to neurological health KATNAL1's impairment may contribute to disorders characterized by defective neuronal morphology such as Alzheimer's disease. It connects with disease-associated proteins like tau a protein that stabilizes microtubules which accumulates abnormally in such disorders.
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This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
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