JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB239220

Anti-KATNAL2 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Goat Polyclonal KATNAL2 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KATNAL2 aa 100-200.

View Alternative Names

Katanin p60 ATPase-containing subunit A-like 2, Katanin p60 subunit A-like 2, p60 katanin-like 2, KATNAL2

1 Images
Western blot - Anti-KATNAL2 antibody (AB239220)
  • WB

Supplier Data

Western blot - Anti-KATNAL2 antibody (AB239220)

Incubated with primary antibody for 1 hour. Detected by chemiluminiscence.

All lanes:

Western blot - Anti-KATNAL2 antibody (ab239220) at 0.3 µg/mL

All lanes:

Human testis lysate at 35 µg

Predicted band size: 61 kDa

false

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human KATNAL2 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q8IYT4

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.1-0.3 µg/mL", "WB-species-notes": "<p>1 hour primary incubation is recommended for this product.</p>" } } }
style
left-column
style
left-column

Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Storage buffer
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
style
left-column

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KATNAL2 also known by its official full name Katanin catalytic subunit A-like 2 is a protein involved in microtubule severing. It possesses a molecular mass of approximately 63 kDa. KATNAL2 is expressed in various tissues throughout the body with notable expression in the brain and reproductive organs. This protein is important for the regulation of the cytoskeleton through the disassembly of microtubules contributing to cellular structure maintenance.
Biological function summary

KATNAL2 plays a role in cellular processes like mitosis and neuronal development. As part of a larger protein complex it interacts with other proteins to facilitate its microtubule severing activity. This action helps in remodeling the microtubule network which is essential for cellular dynamics and morphological changes during cell division and differentiation. The precise assembly and disassembly controlled by KATNAL2 are important for ensuring normal cell function and development.

Pathways

KATNAL2 associates with the microtubule dynamics pathway and is involved in mitotic spindle organization. It interacts with proteins such as katanin p60 which assists in severing microtubules. This interaction allows for the correct segregation of chromosomes during cell division. Additionally KATNAL2 may influence signaling pathways related to cytoskeletal organization demonstrating its importance in maintaining cellular integrity.

Changes in KATNAL2 function link to neurodevelopmental disorders and male infertility. Abnormal expression levels of KATNAL2 have implications in conditions affecting neuronal development where its role alongside proteins such as the tubulin family becomes apparent. Disruption in these pathways related to KATNAL2 can lead to disorders characterized by improper neuronal connections or alterations in testicular structure leading to infertility. Understanding KATNAL2's interaction with related proteins sheds light on its impact on these diseases.
style
left-column
style
left-column

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

Target data

Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.
See full target information KATNAL2
style
left-column

Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in molecular neuroscience 18:1552819 PubMed40206188

2025

The restoration of REST inhibits reactivity of Down syndrome iPSC-derived astrocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Tan Huang,Sharida Fakurazi,Pike-See Cheah,King-Hwa Ling
View all publications
style
left-column
style
left-column
style
right-column

Alternative Products

Primary Antibodies

AB184829

Anti-KATNAL2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KATNAL2 antibody (AB184829)

  • 0
  • 0

Complementary Products

Primary Antibodies

AB111881

Anti-p60 katanin antibody [EPR5071]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-p60 katanin antibody [EPR5071] (AB111881)

  • 0
  • 0
Primary Antibodies

AB237050

Anti-CBWD2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CBWD2 antibody (AB237050)

  • 0
  • 0
Primary Antibodies

AB176689

Anti-ZNF384 antibody

Immunoprecipitation - Anti-ZNF384 antibody (AB176689)

  • 5
  • 1
Primary Antibodies

AB235784

Anti-XRRA1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-XRRA1 antibody (AB235784)

  • 0
  • 0

Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com