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AB244447

Anti-Kazrin antibody

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Rabbit Polyclonal Kazrin antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KAZN aa 600 to C-terminus.

View Alternative Names

C1orf196, KAZ, KIAA1026, HRIHFB2003, KAZN, Kazrin

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-Kazrin antibody (AB244447)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Kazrin antibody (AB244447)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for Kazrin (green) using ab244447 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kazrin antibody (AB244447)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kazrin antibody (AB244447)

Paraffin-embedded human spleen tissue stained for Kazrin using ab244447 at 1/5000 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human KAZN aa 600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q674X7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/5000 - 1/10000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kazrin also known as KAZ is a multifunctional protein involved in several cellular processes. It has an approximate mass of 55 kDa and is expressed in a variety of tissues including skin hair follicles and the cytoplasm of epithelial cells. Kazrin interacts with various proteins influencing cell adhesion proliferation and differentiation. Scientists also study its role in cytoskeletal organization as it binds to cytoskeletal proteins and contributes to cellular structure integrity.
Biological function summary

Kazrin plays a significant role in the maintenance of skin barrier function and epidermal differentiation. It is part of a complex that includes desmosomal and cytoskeletal proteins which together ensure proper cell-cell adhesion. These interactions assist in maintaining the mechanical stress response in tissues therefore contributing to tissue homeostasis. Kazrin influences epithelial morphogenesis and wound healing by modulating the dynamics and organization of actin filaments.

Pathways

Several biological pathways feature Kazrin due to its involvement in cellular adhesion and organization. Notably it participates in the keratinocyte differentiation pathway and cadherin signaling. Within these pathways it interacts with proteins such as desmoplakin and plakophilins which are essential for desmosome assembly and function. By regulating these interactions Kazrin supports the mechanical strength and resilience of cellular structures.

Dysregulation of Kazrin associates with certain skin-related conditions and cancers. Abnormal expression levels can impact epidermolysis bullosa a group of heritable skin blistering disorders by affecting the stability and function of desmosome components. Additionally Kazrin’s interaction with p53 a well-known tumor suppressor protein links it to various cancer progressions. Researchers continue to explore these connections to understand better Kazrin's role in disease mechanisms and potential therapeutic targets.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Component of the cornified envelope of keratinocytes. May be involved in the interplay between adherens junctions and desmosomes. The function in the nucleus is not known.
See full target information KAZN
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Product promise

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