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AB252972

Anti-KBTBD10/KRP1 antibody

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(1 Publication)

Rabbit Polyclonal KBTBD10/KRP1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KLHL41 aa 250-350.

View Alternative Names

KBTBD10, KRP1, KLHL41, Kelch-like protein 41, Kel-like protein 23, Kelch repeat and BTB domain-containing protein 10, Kelch-related protein 1, Sarcosin

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KBTBD10/KRP1 antibody (AB252972)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KBTBD10/KRP1 antibody (AB252972)

Paraffin-embedded human lymph tissue stained for KBTBD10/KRP1 using ab252972 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KBTBD10/KRP1 antibody (AB252972)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KBTBD10/KRP1 antibody (AB252972)

Paraffin-embedded human colon tissue stained for KBTBD10/KRP1 using ab252972 at 1/200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-KBTBD10/KRP1 antibody (AB252972)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-KBTBD10/KRP1 antibody (AB252972)

PFA-fixed, Triton X-100 permeabilized RH-30 (Human bone marrow metastasis cell line) cells stained for KBTBD10/KRP1 (green) using ab252972 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KBTBD10/KRP1 antibody (AB252972)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KBTBD10/KRP1 antibody (AB252972)

Paraffin-embedded human skeletal-muscle tissue stained for KBTBD10/KRP1 using ab252972 at 1/200 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KBTBD10/KRP1 antibody (AB252972)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KBTBD10/KRP1 antibody (AB252972)

Paraffin-embedded human liver tissue stained for KBTBD10/KRP1 using ab252972 at 1/200 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF, WB

applications

Immunogen

Recombinant Fragment Protein within Human KLHL41 aa 250-350. The exact immunogen used to generate this antibody is proprietary information.

O60662

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

The KBTBD10 also known as KRP1 is a protein with a molecular mass of approximately 47 kDa. This protein belongs to the BTB-kelch family and plays a role in processes related to cellular structural organization. The expression of KBTBD10 occurs in a variety of tissues including skeletal muscle and cardiac muscle where it is involved in maintaining muscle integrity and function. Its function in these tissues suggests it might also have roles in other muscle-related processes.
Biological function summary

KBTBD10/KRP1 assists in muscle cell differentiation and survival by modulating actin cytoskeleton dynamics. This protein interacts with actin filaments and contributes to the stability and assembly of the cytoskeletal framework. It acts as a part of larger protein complexes that regulate the cytoskeleton which enables cells to maintain their shape and respond to mechanical stress. KBTBD10 is implicated in cellular signaling that influences transcriptional activities important for muscle maturation and repair.

Pathways

KBTBD10/KRP1 has important roles in the regulation of the actin cytoskeleton pathway and the Wnt signaling pathway. These pathways are key in processes like cell adhesion and signal transduction. In these pathways KBTBD10 interacts with proteins like beta-catenin and other actin-binding proteins which are important in transmitting signals that affect cell motility and gene expression. Its involvement in these pathways highlights its essential role in cellular architecture and signaling networks.

KBTBD10/KRP1 has relevance to muscular diseases such as muscular dystrophy and cardiac disorders. Mutations or dysregulation of KBTBD10 can lead to disruptions in muscle cell stability and function which contribute to the development of these conditions. It associates with proteins like dystrophin and other muscle structural proteins making it integral to maintaining muscle health and function. Understanding KBTBD10's involvement in these diseases can aid in developing targeted therapeutic strategies.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.
See full target information KLHL41
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Experimental and therapeutic medicine 24:539 PubMed35837031

2022

Formation of three-dimensional cell aggregates expressing lens-specific proteins in various cultures of human iris-derived tissue cells and iPS cells.

Applications

Unspecified application

Species

Unspecified reactive species

Noriko Hiramatsu,Naoki Yamamoto,Yu Kato,Noriaki Nagai,Sumito Isogai,Kazuyoshi Imaizumi
View all publications
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Product promise

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