Anti-KBTBD7 antibody

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

KBTBD7 also known as Kelch repeat and BTB domain-containing protein 7 plays a significant role in cellular processes. It exhibits a molecular mass of approximately 67 kDa. KBTBD7 expresses across various tissues with notable levels in the brain and kidney. The protein contains a BTB/POZ domain and kelch repeats which are essential for its interaction with other proteins and participation in ubiquitin-mediated proteolysis.

Biological function summary

KBTBD7 participates in cellular regulation by mediating protein degradation. It forms part of a complex involved in ubiquitin-protein ligase activity facilitating the tagging of proteins for degradation. The protein's activity is important in maintaining protein homeostasis and removing damaged or unnecessary proteins from the cell. Its involvement in these processes emphasizes its role in cellular quality control.

Pathways

KBTBD7 influences the ubiquitin-proteasome pathway important for protein turnover. This pathway regulates the degradation of key proteins affecting various cellular activities. KBTBD7 interacts with proteins such as CUL3 where it acts as an adaptor in the cullin-RING E3 ubiquitin ligase (CRL) complexes. Through these interactions it indirectly influences cellular events governed by ubiquitin-mediated processes.

Associated diseases and disorders

KBTBD7 has associations with neurodegenerative diseases and cancer. Dysregulation in the ubiquitin-proteasome pathway involving KBTBD7 contributes to the accumulation of misfolded proteins affecting diseases like Alzheimer's. In cancer improper KBTBD7 activity might lead to unrestrained cell proliferation due to disrupted protein degradation cycles. Connections with proteins like Cyclins highlight the impact of its regulatory malfunction in pathological states.