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AB216696

Anti-KCNA3 antibody

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(1 Publication)

Rabbit Polyclonal KCNA3 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human KCNA3 aa 500-550 conjugated to Keyhole Limpet Haemocyanin.

View Alternative Names

HGK5, KCNA3, Potassium voltage-gated channel subfamily A member 3, HLK3, HPCN3, Voltage-gated K(+) channel HuKIII, Voltage-gated potassium channel subunit Kv1.3

1 Images
Western blot - Anti-KCNA3 antibody (AB216696)
  • WB

Supplier Data

Western blot - Anti-KCNA3 antibody (AB216696)

All lanes:

Western blot - Anti-KCNA3 antibody (ab216696) at 1/300 dilution

All lanes:

HepG2 lysate

Secondary

All lanes:

Goat Anti-Rabbit IgG Antibody (H+L), HRP at 1/5000 dilution

Predicted band size: 63 kDa

false

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human KCNA3 aa 500-550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P22001

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Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KCNA3 also known as Kv1.3 is a voltage-gated potassium channel that plays a part in controlling membrane potential in cells. It consists of a protein with a mass of approximately 57 kDa. KCNA3 is mainly expressed in the immune system particularly in T lymphocytes macrophages and microglia. Its expression also extends to the central nervous system where it helps regulate neuronal excitability.
Biological function summary

This potassium channel contributes to the activation and proliferation of T cells. It typically forms a complex with other ion channels to coordinate cellular responses to stimuli. KCNA3 regulates calcium signaling and helps balance the cell's internal environment by facilitating potassium efflux providing support for various immune functions.

Pathways

KCNA3 is involved in both the immune response and intracellular signaling pathways. It plays roles in pathways like the calcium signaling pathway and the MAPK signal transduction cascade. Through these pathways it often interacts with other proteins such as calcium release-activated calcium (CRAC) channels to maintain cellular homeostasis and function.

KCNA3 has associations with autoimmune conditions like multiple sclerosis and rheumatoid arthritis. Dysfunction in KCNA3's regulation of T cell activity can lead to abnormal immune responses. It's linked with the protein CTLA-4 which is another immune checkpoint molecule involved in autoimmune pathologies. This makes KCNA3 a potential target for therapy in related autoimmune diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Isoform 1. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.. Isoform 2. Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.. Isoform 3. Lacks voltage-gated potassium channel activity.
See full target information KCNA3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

World journal of stem cells 12:500-513 PubMed32742567

2020

Cytotoxicity of nonylphenol on spermatogonial stem cells phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jun-Hao Lei,Wen Yan,Chun-Hua Luo,Yu-Ming Guo,Yang-Yang Zhang,Xing-Huan Wang,Xin-Jun Su
View all publications
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