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AB66640

Anti-KCNQ3 antibody

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(4 Publications)

Rabbit Polyclonal KCNQ3 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human KCNQ3.

View Alternative Names

Potassium voltage-gated channel subfamily KQT member 3, KQT-like 3, Potassium channel subunit alpha KvLQT3, Voltage-gated potassium channel subunit Kv7.3, KCNQ3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KCNQ3 antibody (AB66640)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KCNQ3 antibody (AB66640)

IHC image of ab66640 staining in human colon formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab66640, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.

For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human KCNQ3. The exact immunogen used to generate this antibody is proprietary information.

O43525

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Sodium Potassium ATPase antibody [EP1845Y] - Plasma Membrane Loading Control (AB76020)

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purity
Whole antiserum
Storage buffer
Constituents: Whole serum
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Pore-forming subunit of the voltage-gated potassium (Kv) M-channel which is responsible for the M-current, a key controller of neuronal excitability (PubMed : 16319223, PubMed : 27564677, PubMed : 28793216, PubMed : 9872318). M-channel is composed of pore-forming subunits KCNQ2 and KCNQ3 assembled as heterotetramers (PubMed : 14534157, PubMed : 16319223, PubMed : 27564677, PubMed : 9872318). The native M-current has a slowly activating and deactivating potassium conductance which plays a critical role in determining the subthreshold electrical excitability of neurons as well as the responsiveness to synaptic inputs (PubMed : 14534157, PubMed : 16319223, PubMed : 28793216). M-channel is selectively permeable in vitro to other cations besides potassium, in decreasing order of affinity K(+) > Rb(+) > Cs(+) > Na(+) (PubMed : 28793216). M-channel association with SLC5A3/SMIT1 alters channel ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) (PubMed : 28793216). Suppressed by activation of M1 muscarinic acetylcholine receptors (PubMed : 10713961). KCNQ3 also associates with KCNQ5 to form a functional channel in vitro and may also contribute to the M-current in brain (PubMed : 11159685).
See full target information KCNQ3
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of clinical medicine 12: PubMed37048724

2023

Comparative Transcriptomic Analysis of Archival Human Vestibular Schwannoma Tissue from Patients with and without Tinnitus.

Applications

Unspecified application

Species

Unspecified reactive species

Krishna Bommakanti,Richard Seist,Phanidhar Kukutla,Murat Cetinbas,Shelley Batts,Ruslan I Sadreyev,Anat Stemmer-Rachamimov,Gary J Brenner,Konstantina M Stankovic

Science advances 8:eabo3625 PubMed35857840

2022

Electro-mechanical coupling of KCNQ channels is a target of epilepsy-associated mutations and retigabine.

Applications

Unspecified application

Species

Unspecified reactive species

Nien-Du Yang,Richard Kanyo,Lu Zhao,Jingru Li,Po Wei Kang,Alex Kelly Dou,Kelli McFarland White,Jingyi Shi,Jeanne M Nerbonne,Harley T Kurata,Jianmin Cui

Neuron 106:649-661.e4 PubMed32197063

2020

Muscarinic M1 Receptors Modulate Working Memory Performance and Activity via KCNQ Potassium Channels in the Primate Prefrontal Cortex.

Applications

Unspecified application

Species

Unspecified reactive species

Veronica C Galvin,Sheng Tao Yang,Constantinos D Paspalas,Yang Yang,Lu E Jin,Dibyadeep Datta,Yury M Morozov,Taber C Lightbourne,Adam S Lowet,Pasko Rakic,Amy F T Arnsten,Min Wang

PloS one 13:e0192122 PubMed29579054

2018

The expression and function of KCNQ potassium channels in human chorionic plate arteries from women with normal pregnancies and pre-eclampsia.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaohong Wei,Yujiao Zhang,Benlan Yin,Jing Wen,Jun Cheng,Xiaodong Fu
View all publications
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Product promise

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