AB5199

Anti-KDM2B antibody

Name: Anti-KDM2B antibody (ab5199) | Abcam
Brand: Abcam Limited
SKU: AB5199
Rating: 4 (2 reviews)

(2 Reviews)

(10 Publications)

Goat Polyclonal KDM2B antibody. Suitable for IHC-P and reacts with Human samples. Cited in 10 publications. Immunogen corresponding to Synthetic Peptide within Human KDM2B aa 1300 to C-terminus.

View Alternative Names

CXXC2, FBL10, FBXL10, JHDM1B, NDY1, PCCX2, KDM2B, Lysine-specific demethylase 2B, CXXC-type zinc finger protein 2, F-box and leucine-rich repeat protein 10, F-box protein FBL10, F-box/LRR-repeat protein 10, JmjC domain-containing histone demethylation protein 1B, Jumonji domain-containing EMSY-interactor methyltransferase motif protein, Protein-containing CXXC domain 2, [Histone-H3]-lysine-36 demethylase 1B, Protein JEMMA

Key facts

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human KDM2B aa 1300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8NHM5

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Purification notes

Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.

Storage buffer

pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed : 16362057, PubMed : 17994099, PubMed : 26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed : 16362057, PubMed : 17994099, PubMed : 26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed : 16362057, PubMed : 17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable).

See full target information KDM2B

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Publications (10)

Recent publications for all applications. Explore the full list and refine your search

BMC cardiovascular disorders 25:141 PubMed40021969

2025

Identification of the CeRNA axis of circ_0000006/miR-483-5p/KDM2B in the progression of aortic aneurysm to aorta dissection.

Applications

Unspecified application

Species

Unspecified reactive species

Yong Liu,Xiong Tan,Liang Wang,Weitao Jin,Yangchen He,Yu Yan,Kai Hu,Hao Wang,Chaohu Xiang,Ming Hou,Yinglong Lai

Bioengineered 12:12227-12235 PubMed34783291

2021

Knockdown of lysine (K)-specific demethylase 2B KDM2B inhibits glycolysis and induces autophagy in lung squamous cell carcinoma cells by regulating the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zhonghai Xie,Hongwei Li,Jin Zang

Biochemistry and biophysics reports 25:100912 PubMed33537462

2021

Intestinal TMEM16A control luminal chloride secretion in a NHERF1 dependent manner.

Applications

Unspecified application

Species

Unspecified reactive species

Tultul Saha,Joydeep Aoun,Mikio Hayashi,Sheikh Irshad Ali,Paramita Sarkar,Prasanta Kumar Bag,Normand Leblanc,Nadia Ameen,Owen M Woodward,Kazi Mirajul Hoque

Journal of virology 93: PubMed30996097

2019

Interplay between the Epigenetic Enzyme Lysine (K)-Specific Demethylase 2B and Epstein-Barr Virus Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Romina C Vargas-Ayala,Antonin Jay,Francesca Manara,Mohamed Ali Maroui,Hector Hernandez-Vargas,Audrey Diederichs,Alexis Robitaille,Cecilia Sirand,Maria Grazia Ceraolo,Maria Carmen Romero-Medina,Marie Pierre Cros,Cyrille Cuenin,Geoffroy Durand,Florence Le Calvez-Kelm,Lucia Mundo,Lorenzo Leoncini,Evelyne Manet,Zdenko Herceg,Henri Gruffat,Rosita Accardi

Cell death & disease 9:1123 PubMed30409964

2018

miR-146b promotes cell proliferation and increases chemosensitivity, but attenuates cell migration and invasion via FBXL10 in ovarian cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Meina Yan,Xinxin Yang,Rong Shen,Chengjiang Wu,Hui Wang,Qing Ye,Peifang Yang,Lubin Zhang,Miao Chen,Bing Wan,Qinqin Zhang,Sheng Xia,Xiaodong Lu,Genbao Shao,Xiaoming Zhou,Jun Yu,Qixiang Shao

Experimental and therapeutic medicine 15:5100-5106 PubMed29805536

2018

Vildagliptin, a DPP4 inhibitor, alleviates diabetes-associated cognitive deficits by decreasing the levels of apoptosis-related proteins in the rat hippocampus.

Applications

Unspecified application

Species

Unspecified reactive species

Dan-Dan Zhang,Nan Shi,Hui Fang,Liang Ma,Wei-Ping Wu,Ya-Zhong Zhang,Jin-Li Tian,Luo-Bing Tian,Kang Kang,Si Chen

American journal of physiology. Renal physiology 311:F343-51 PubMed27279487

2016

The NHERF1 PDZ1 domain and IRBIT interact and mediate the activation of Na+/H+ exchanger 3 by ANG II.

Applications

Unspecified application

Species

Unspecified reactive species

Peijian He,Luqing Zhao,Yi Ran No,Serhan Karvar,C Chris Yun

The Journal of clinical investigation 125:3519-31 PubMed26258413

2015

Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss.

Applications

Unspecified application

Species

Unspecified reactive species

Peijian He,Luqing Zhao,Lixin Zhu,Edward J Weinman,Roberto De Giorgio,Michael Koval,Shanthi Srinivasan,C Chris Yun

The Journal of biological chemistry 286:33061-9 PubMed21757686

2011

Lysine-specific demethylase 2B (KDM2B)-let-7-enhancer of zester homolog 2 (EZH2) pathway regulates cell cycle progression and senescence in primary cells.

Applications

Species

Mouse

Alexandros Tzatsos,Polina Paskaleva,Stephania Lymperi,Gianmarco Contino,Svetlana Stoykova,Zhao Chen,Kwok-Kin Wong,Nabeel Bardeesy

Cell death and differentiation 18:1184-95 PubMed21252908

2011

F-box protein 10, an NF-κB-dependent anti-apoptotic protein, regulates TRAIL-induced apoptosis through modulating c-Fos/c-FLIP pathway.

Applications

Unspecified application

Species

Unspecified reactive species

R Ge,Z Wang,Q Zeng,X Xu,A F Olumi

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-KDM2B antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Purification notes

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (10)

Product promise