Rabbit Polyclonal KDM4A / JHDM3A / JMJD2A antibody. Suitable for WB and reacts with Human samples. Cited in 13 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KDM4A aa 550-750.
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- Development (Cambridge, England) 146:2019PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants.Applications:Unspecified applicationReactive species:Unspecified reactive speciesRavindra S Prajapati et. al.PubMed 31806661
- Scientific reports 7:110942017KDM4A regulates HIF-1 levels through H3K9me3.Applications:Unspecified applicationReactive species:Unspecified reactive speciesGrzegorz Dobrynin et. al.PubMed 28894274
- Breast cancer : basic and clinical research 10:169-1752016KDM4C Activity Modulates Cell Proliferation and Chromosome Segregation in Triple-Negative Breast Cancer.
- BioMed research international 2016:26349762016Role of Histone Demethylases in Cardiomyocytes Induced to Hypertrophy.
- Journal of molecular biology 426:3467-772014Gene-specific methylation control of H3K9 and H3K36 on neurotrophic BDNF versus astroglial GFAP genes by KDM4A/C regulates neural stem cell differentiation.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnna Cascante et. al.PubMed 24747049
- Physiological genomics 45:287-992013RNA-sequencing analysis of high glucose-treated monocytes reveals novel transcriptome signatures and associated epigenetic profiles.
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology 26:449-5920115-Aza-2'-deoxycytidine reactivates gene expression via degradation of pRb pocket proteins.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZhixing Zheng,Lian Li,Xiangyu Liu,Donglai Wang,Bo Tu,Lina Wang,Haiying Wang,Wei-Guo ZhuPubMed 21990374
- Journal of virology 85:3283-932011Histone demethylase JMJD2A regulates Kaposi's sarcoma-associated herpesvirus replication and is targeted by a viral transcriptional factor.Applications:Unspecified applicationReactive species:Unspecified reactive speciesPei-Ching Chang,Latricia D Fitzgerald,Datsun A Hsia,Yoshihiro Izumiya,Chun-Yi Wu,Wen-Ping Hsieh,Su-Fang Lin,Mel Campbell,Kit S Lam,Paul A Luciw,Clifford G Tepper,Hsing-Jien KungPubMed 21228229
- Developmental cell 19:460-82010Histone demethylase JmjD2A regulates neural crest specification.Applications:ChIPReactive species:ChickenPablo Hernan Strobl-Mazzulla,Tatjana Sauka-Spengler,Marianne Bronner-FraserPubMed 20833367
- Molecular cell 34:497-5092009Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis.Applications:ChIPReactive species:HumanJoseph E Aslan,Huihong You,Danielle M Williamson,Jessica Endig,Robert T Youker,Laurel Thomas,Hongjun Shu,Yuhong Du,Robert L Milewski,Matthew H Brush,Anthony Possemato,Kam Sprott,Haian Fu,Kenneth D Greis,Douglas N Runckel,Arndt Vogel,Gary ThomasPubMed 19481529
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
- Standard buffer
- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Fragment Protein within Human KDM4A aa 550-750. The exact immunogen used to generate this antibody is proprietary information. Database link O75164
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Reactivity data
Select an application| WB | |
|---|---|
| Human | Tested |
| Rat | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/2000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Target data
Function
Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. Isoform 2. Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.
Alternative names
JHDM3A, JMJD2, JMJD2A, KIAA0677, KDM4A, Lysine-specific demethylase 4A, JmjC domain-containing histone demethylation protein 3A, Jumonji domain-containing protein 2A, [histone H3]-trimethyl-L-lysine(36) demethylase 4A, [histone H3]-trimethyl-L-lysine(9) demethylase 4A
Recommended products
Rabbit Polyclonal KDM4A / JHDM3A / JMJD2A antibody. Suitable for WB and reacts with Human samples. Cited in 13 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KDM4A aa 550-750.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
- Standard buffer
- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Fragment Protein within Human KDM4A aa 550-750. The exact immunogen used to generate this antibody is proprietary information. Database link O75164
- Purity
- Whole antiserum
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
If you do not find a host species to meet your needs, our catalogue and custom Chimeric range provides scientists the specificity of Abcam's RabMAbs in the species backbone of your choice. Remember to also review our range of edited cell lines, proteins and biochemicals relevant to your target that may help you further your research goals.
Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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Full details and terms and conditions can be found here:
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1 product image
Western blot - Anti-KDM4A / JHDM3A / JMJD2A antibody (ab24545)
All lanes: Western blot - Anti-KDM4A / JHDM3A / JMJD2A antibody (ab24545) at 1/2000 dilution
All lanes: HeLa nuclear extract
Predicted band size: 120 kDa
Observed band size: 130 kDa
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