AB92533

Anti-KDM5A / Jarid1A / RBBP2 antibody

Name: Anti-KDM5A / Jarid1A / RBBP2 antibody (ab92533) | Abcam
Brand: Abcam Limited
SKU: AB92533
Price: 535 USD
Availability: InStock

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(4 Publications)

Rabbit Polyclonal KDM5A / Jarid1A / RBBP2 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human KDM5A aa 1600 to C-terminus.

View Alternative Names

JARID1A, RBBP2, RBP2, KDM5A, Lysine-specific demethylase 5A, Histone demethylase JARID1A, Jumonji/ARID domain-containing protein 1A, Retinoblastoma-binding protein 2, [histone H3]-trimethyl-L-lysine(4) demethylase 5A, RBBP-2

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KDM5A / Jarid1A / RBBP2 antibody (AB92533)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KDM5A / Jarid1A / RBBP2 antibody (AB92533)

ab92533 at 1/250 dilution staining KDM5A / Jarid1A / RBBP2 in human prostate carcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection : DAB staining.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KDM5A / Jarid1A / RBBP2 antibody (AB92533)

Immunohistochemical analysis of parafin embedded human breast carcinoma tissue labelling KDM5A/Jarid1A/RBBP2 with ab92533 at 1 in 250 dilution.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human KDM5A aa 1600 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P29375

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chinese hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Horse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Product details

Concentration is optimized for IHC and not determined

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA

Shipped at conditions

Blue Ice

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Regulates specific gene transcription through DNA-binding on 5'-CCGCCC-3' motif (PubMed : 18270511). May stimulate transcription mediated by nuclear receptors. Involved in transcriptional regulation of Hox proteins during cell differentiation (PubMed : 19430464). May participate in transcriptional repression of cytokines such as CXCL12. Plays a role in the regulation of the circadian rhythm and in maintaining the normal periodicity of the circadian clock. In a histone demethylase-independent manner, acts as a coactivator of the CLOCK-BMAL1-mediated transcriptional activation of PER1/2 and other clock-controlled genes and increases histone acetylation at PER1/2 promoters by inhibiting the activity of HDAC1 (By similarity). Seems to act as a transcriptional corepressor for some genes such as MT1F and to favor the proliferation of cancer cells (PubMed : 27427228).

See full target information KDM5A

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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

European journal of medical research 30:284 PubMed40229896

2025

The KDM5A/HOXA5 axis regulates osteosarcoma progression via activating the Wnt/β-catenin pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Luo,Youzhi He,Yuxia Xu,Yongfu Wang,Li Yang

International journal of medical sciences 21:2158-2169 PubMed39239542

2024

Multiple Comprehensive Analyses Identify Lysine Demethylase KDM as a Potential Therapeutic Target for Pancreatic Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Wan-Jou Shen,Hsuan-Min Kao,Chih-Yang Wang,Rubina Kousar,Jing-Shan Lin,Ching-Chung Ko,Hung-Yun Lin,Hoang Dang Khoa Ta,Gangga Anuraga,Do Thi Minh Xuan,Sachin Kumar,Sanskriti Dey,Ngoc Phung Ly,Wei-Jan Wang

Journal of experimental & clinical cancer research : CR 39:223 PubMed33087165

2020

Activation of the KDM5A/miRNA-495/YTHDF2/m6A-MOB3B axis facilitates prostate cancer progression.

Applications

Unspecified application

Species

Unspecified reactive species

Chen Du,Caihong Lv,Yue Feng,Siwen Yu

OncoTargets and therapy 13:5857-5868 PubMed32606796

2020

Long Non-Coding RNA TUG1 Promotes Cell Proliferation and Inhibits Cell Apoptosis, Autophagy in Clear Cell Renal Cell Carcinoma via MiR-31-5p/FLOT1 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Dong Lv,Ying Xiang,Qi Yang,Juncheng Yao,Qiang Dong

View all publications

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Product promise

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For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

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Anti-KDM5A / Jarid1A / RBBP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KDM5A / Jarid1A / RBBP2 antibody (AB92533)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KDM5A / Jarid1A / RBBP2 antibody (AB92533)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Product details

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Product protocols

Target data

Publications (4)

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