AB197988

Anti-Kif2a antibody

Name: Anti-Kif2a antibody (ab197988) | Abcam
Brand: Abcam Limited
SKU: AB197988
Price: 535 USD
Availability: InStock

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(14 Publications )

Rabbit Polyclonal KIF2A antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 14 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KIF2A.

View Alternative Names

KIF2, KNS2, KIF2A, Kinesin-like protein KIF2A, Kinesin-2, hK2

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KIF2A. The exact immunogen used to generate this antibody is proprietary information.

O00139

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Reactivity data

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kif2a known as Kinesin family member 2A is a motor protein involved in microtubule dynamics. It has a mass around 93 kDa and provides mechanical force by depolymerizing microtubules. Kif2a expresses mainly in the brain but shows presence in other tissues as well. By regulating microtubule dynamics Kif2a plays a role in cellular assembly processes including mitotic spindle formation and chromosome segregation during cell division.

Biological function summary

Kif2a assists in microtubule destabilization and plays a critical role in ensuring proper mitotic spindle assembly. It doesn't function alone but interacts with other proteins to exert its function. Kif2a forms part of a machinery complex responsible for chromosome alignment and segregation. This complex action contributes significantly to the accuracy of cell division ensuring cell viability.

Pathways

The Kif2a protein engages in critical cellular pathways like the spindle assembly checkpoint and chromosomal passenger complex pathway. Kif2a's activity influences the Aurora B kinase a major regulator in the chromosome segregation process. Through these interactions it secures the maintenance of genomic stability by preventing improper chromosome segregation and aneuploidy.

Kif2a's dysfunction links to neurodevelopmental disorders and various cancers. Impaired function in neural development can relate to altered Kif2a activity affecting brain development processes. Furthermore abnormal Kif2a expression found in cancer cells shows its involvement in oncogenesis. In neurodevelopmental disorders its interaction with proteins like Lis1 connects it to abnormalities in neuronal migration highlighting its critical impact on neural health.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.

See full target information KIF2A

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Publications (14)

Recent publications for all applications. Explore the full list and refine your search

Histology and histopathology 40:1239-1251 PubMed39587911

2024

Hsa_circ_0088036 promotes tumorigenesis and chemotherapy resistance in hepatocellular carcinoma via the miR-140-3p/KIF2A axis.

Applications

Unspecified application

Species

Unspecified reactive species

Zhong Wang,Lei Wang,Guoqing Yin,Heng Li,Rong Zhang,Yuan Feng,Wen Chang

Oncology letters 28:396 PubMed38974111

2024

KIF2A correlates with lymphovascular invasion and higher tumor stage, and can be used to predict worse prognosis in patients with endometrial carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Shi,Liyang Yin,Yajing Hao,Jurong Wang,Weiyue Zhou

Open medicine (Warsaw, Poland) 17:1780-1787 PubMed36447525

2022

HPV16 E6E7 up-regulates KIF2A expression by activating JNK/c-Jun signal, is beneficial to migration and invasion of cervical cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yuyan Wang,Jinfeng Wang,Anqi Zhao,Xin Huang,Xin Zhang

Histology and histopathology 38:431-441 PubMed36196919

2022

Circ_SATB2 knockdown inhibits the tumorigenesis of non-small cell lung cancer via miR-760/KIF2A axis.

Applications

Unspecified application

Species

Unspecified reactive species

Pengchao Zheng,Jianhua Jiang,Lei Li,Liang Wei,Jie Li,Ling Jin

Experimental and therapeutic medicine 24:683 PubMed36277155

2022

KIF2A participates in the progression of hepatocellular carcinoma and angiogenesis by interacting with Notch1.

Applications

Unspecified application

Species

Unspecified reactive species

Qi Wu,Xuting Ren,Yun Chen,Ye Jin,Xiaobo Zhan,Changfeng Liu,Bing Zhang

The Journal of clinical endocrinology and metabolism 107:3100-3110 PubMed36017587

2022

Inflammatory Cytokines Rewire the Proinsulin Interaction Network in Human Islets.

Applications

Unspecified application

Species

Unspecified reactive species

Duc T Tran,Anita Pottekat,Kouta Lee,Megha Raghunathan,Salvatore Loguercio,Saiful A Mir,Adrienne W Paton,James C Paton,Peter Arvan,Randal J Kaufman,Pamela Itkin-Ansari

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 18:55 PubMed35718777

2022

KIF2A decreases IL-33 production and attenuates allergic asthmatic inflammation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhengxia Wang,Jingjing Wu,Jingxian Jiang,Qiyun Ma,Meijuan Song,Tingting Xu,Yanan Liu,Zhongqi Chen,Yanmin Bao,Mao Huang,Mingshun Zhang,Ningfei Ji

Oncology letters 24:256 PubMed35765280

2022

Aberrant kinesin family member 2A signifies tumor size and invasion, and may help predict prognosis of patients with papillary thyroid carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoyi Zhang,Mian Wu,Gongling Peng,Wenhuan Li,Zhe Guo,Hai Li,Ming Jiang

Journal of clinical laboratory analysis 36:e24313 PubMed35313389

2022

Kinesin family member 2A links with advanced tumor stage, reduced chemosensitivity and worse prognosis in gastric cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fei Bai,Zhuo He,Huijun Zhou,Wei Gan

Cancer cell international 22:81 PubMed35164763

2022

Circular RNA circ_IRAK3 contributes to tumor growth through upregulating KIF2A via adsorbing miR-603 in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Wang,Jingruo Li,Lin Li,Zhuo Chen,Nan Wang,Mingzhi Zhu,Hailong Mi,Youyi Xiong,Guangcheng Guo,Yuanting Gu

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Kif2a antibody

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Alternative Products

Primary Antibodies

Complementary Products

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (14)

Product promise