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AB224324

Anti-Kinectin 1 antibody

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Rabbit Polyclonal Kinectin 1 antibody. Suitable for IHC-P, WB, ICC/IF and reacts with Human samples. Immunogen corresponding to Recombinant Fragment Protein within Human KTN1 aa 150-350.

View Alternative Names

CG1, KIAA0004, KTN1, Kinectin, CG-1 antigen, Kinesin receptor

4 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kinectin 1 antibody (AB224324)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kinectin 1 antibody (AB224324)

Paraffin-embedded human cerebral cortex tissue stained for Kinectin 1 using ab224324 at 1/50 dilution in immunohistochemical analysis.

Western blot - Anti-Kinectin 1 antibody (AB224324)
  • WB

Supplier Data

Western blot - Anti-Kinectin 1 antibody (AB224324)

All lanes:

Western blot - Anti-Kinectin 1 antibody (ab224324) at 1/100 dilution

All lanes:

RT4 (human urinary bladder cancer cell line) cell lysate

Predicted band size: 156 kDa

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Immunocytochemistry/ Immunofluorescence - Anti-Kinectin 1 antibody (AB224324)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Kinectin 1 antibody (AB224324)

PFA-fixed/Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells stained for Kinectin 1 (green) using ab224324 at 4 μg/ml in ICC/IF.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kinectin 1 antibody (AB224324)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Kinectin 1 antibody (AB224324)

Paraffin-embedded human testis tissue stained for Kinectin 1 using ab224324 at 1/50 dilution in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human KTN1 aa 150-350. The exact immunogen used to generate this antibody is proprietary information.

Q86UP2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Kinectin 1 also known as kinectin is a protein with a molecular mass of approximately 156 kDa. Predominantly located in the endoplasmic reticulum kinectin 1 functions as a membrane anchor for kinesin motors. This protein facilitates the movement of organelles along microtubules by binding to kinesin which is essential for intracellular transport. Kinectin 1 expression can be detected in various tissues but is notably high in the brain liver and kidney reflecting its involvement in critical cellular processes.
Biological function summary

Kinectin 1 plays an important role in the organization of the cytoskeleton. It interacts with other cytoskeletal components and participates in the assembly of the Golgi apparatus. Kinectin 1 also forms part of the larger motor protein complex that includes kinesin light chains and other adaptors critical for vesicle-mediated transport. This complex is responsible for maintaining cellular homeostasis and efficient distribution of materials within the cell.

Pathways

Kinectin 1 is integral to the intracellular trafficking and signaling pathways. It is closely associated with the secretory and endocytic pathways both of which depend on accurate and timely transport of proteins and membranes. Kinectin 1 collaborates with proteins like kinesin and cytoplasmic dynein facilitating directional transport along microtubules. This interaction is vital for the proper functioning of cellular logistics and signaling cascades.

Research shows that kinectin 1 is connected to neurodegenerative diseases such as Alzheimer's. Disruption in its normal function or expression can lead to impaired intracellular transport contributing to the pathogenesis of such conditions. Additionally kinectin 1 interacts with kinesin motor proteins in processes that when dysregulated may relate to metabolic disorders impacting cellular energy distribution. Understanding these connections could inform therapeutic strategies for related diseases.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Receptor for kinesin thus involved in kinesin-driven vesicle motility. Accumulates in integrin-based adhesion complexes (IAC) upon integrin aggregation by fibronectin.
See full target information KTN1
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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.
For full details, please see our Terms & Conditions
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Associated Products

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Alternative Product
Primary Antibodies

AB231002

Anti-Kinectin 1 antibody

primary-antibodies

kinectin-1-antibody-ab231002

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