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AB233416

Anti-KLB antibody

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(4 Publications)

Rabbit Polyclonal KLB antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Beta-klotho aa 500-650.

View Alternative Names

Beta-klotho, BKL, BetaKlotho, Klotho beta-like protein, KLB

3 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLB antibody (AB233416)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLB antibody (AB233416)

Formalin-fixed, paraffin-embedded human pancreas tissue stained for KLB using ab233416 at 20 μg/ml in immunohistochemical analysis. AEC staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLB antibody (AB233416)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLB antibody (AB233416)

Formalin-fixed, paraffin-embedded human liver tissue stained for KLB using ab233416 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLB antibody (AB233416)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLB antibody (AB233416)

Formalin-fixed, paraffin-embedded human kidney tissue stained for KLB using ab233416 at 20 μg/ml in immunohistochemical analysis. AEC staining.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Beta-klotho aa 500-650. The exact immunogen used to generate this antibody is proprietary information.

Q86Z14

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Purification notes
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
Storage buffer
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity).
See full target information Beta-klotho
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Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Discover oncology 16:1655 PubMed40879845

2025

KLB as a potential prognostic biomarker and therapeutic target in colorectal cancer: insights from multi omics and single cell analyses.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaofei Bi,Wenjin Zhang,Meimei Shen,Guicheng Wu,Chengmei Fang,Jian Gao

Cell death and differentiation 31:738-752 PubMed38594444

2024

IFI35 regulates non-canonical NF-κB signaling to maintain glioblastoma stem cells and recruit tumor-associated macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Daqi Li,Xiefeng Wang,Kexin Chen,Danyang Shan,Gaoyuan Cui,Wei Yuan,Qiankun Lin,Ryan C Gimple,Deobrat Dixit,Chenfei Lu,Danling Gu,Hao You,Jiancheng Gao,Yangqing Li,Tao Kang,Junlei Yang,Hang Yu,Kefan Song,Zhumei Shi,Xiao Fan,Qiulian Wu,Wei Gao,Zhe Zhu,Jianghong Man,Qianghu Wang,Fan Lin,Weiwei Tao,Stephen C Mack,Yun Chen,Junxia Zhang,Chaojun Li,Nu Zhang,Yongping You,Xu Qian,Kailin Yang,Jeremy N Rich,Qian Zhang,Xiuxing Wang

Frontiers in pharmacology 14:1148737 PubMed37077819

2023

Geniposide plus chlorogenic acid reverses non-alcoholic steatohepatitis regulation of gut microbiota and bile acid signaling in a mouse model .

Applications

Unspecified application

Species

Unspecified reactive species

Hongshan Li,Yingfei Xi,Xin Xin,Qin Feng,Yiyang Hu

Nutrition & metabolism 17:34 PubMed32377219

2020

Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Hongshan Li,Yingfei Xi,Xin Xin,Huajie Tian,Yiyang Hu
View all publications
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