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AB20947

Anti-Klebsiella pneumoniae antibody

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(4 Publications)

Rabbit Polyclonal Klebsiella pneumoniae antibody. Suitable for ICC/IF and reacts with Klebsiella pneumoniae samples. Cited in 4 publications.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Klebsiella pneumoniae

Applications

ICC/IF

applications

Specificity

Polyvalent for multiple Klebsiella antigens. Product is unabsorbed and may crossreact with related Enterobacteriaceae.

Reactivity data

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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Purification notes
>95% pure.
Storage buffer
Preservative: 0.1% Sodium azide Constituents: 0.0268% PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle

Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

Klebsiella pneumoniae sometimes referred to as Kleb pneumo is a gram-negative bacterium known for its role in human infections. It has a molecular mass of around 5.5 million Daltons. Klebsiella pneumoniae is typically found in the intestinal tract of humans and animals. Beyond the intestines it can colonize the respiratory tract and other mucosal surfaces making it a common pathogen in hospital settings. In laboratory cultures Klebsiella pneumoniae exhibits mucoid colonies due to its polysaccharide capsule which contributes to its virulence.
Biological function summary

Klebsiella pneumoniae plays a significant role in infections. The organism is noted for its pathogenic mechanisms which include evading host immune responses and harboring antibiotic resistance genes. It produces a robust polysaccharide capsule an important virulence factor and a siderophore production system for iron acquisition aiding in infection and persistence in host tissues. The bacterium does not form interlinked complexes with other microorganisms but it interacts with host cells and immune system components influencing the immune response.

Pathways

Klebsiella pneumoniae impacts metabolic routes related to its persistence and virulence. Iron uptake pathways important for its survival and growth involve proteins such as enterobactin which are essential for iron binding and transport. The bacterium also engages in nitrogen metabolism pathways that facilitate its growth in nutrient-limiting environments. Its ability to manipulate these pathways allows it to thrive in diverse environments including host tissues.

Klebsiella pneumoniae is implicated in a variety of infections such as pneumonia and urinary tract infections. The bacterium's capsule a significant virulence factor plays a central role in these infections by preventing phagocytosis. In pneumonia Klebsiella pneumoniae can be particularly severe and is frequently associated with multidrug-resistant strains. Through mechanisms like beta-lactamase production the bacterium ties into the broader issue of antimicrobial resistance complicating treatment options for infections it causes.

Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Publications (4)

Recent publications for all applications. Explore the full list and refine your search

Chemical science 11:3054-3067 PubMed34122810

2020

Antibody-recruiting protein-catalyzed capture agents to combat antibiotic-resistant bacteria.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew N Idso,Ajay Suresh Akhade,Mario L Arrieta-Ortiz,Bert T Lai,Vivek Srinivas,James P Hopkins,Ana Oliveira Gomes,Naeha Subramanian,Nitin Baliga,James R Heath

The Journal of veterinary medical science 79:1167-1171 PubMed28529273

2017

Septicemic invasive Klebsiella pneumoniae infection in a cynomolgus monkey (Macaca fascicularis) with severe diffused suppurative meningoencephalitis.

Applications

Unspecified application

Species

Unspecified reactive species

Kazufumi Kasuya,Kou Takayama,Makiko Bito,Natsumi Shimokubo,Ryosuke Kawashima,Tomoyuki Shibahara

PloS one 9:e110703 PubMed25333280

2014

Identification of antigenic proteins of the nosocomial pathogen Klebsiella pneumoniae.

Applications

Unspecified application

Species

Unspecified reactive species

Sebastian Hoppe,Frank F Bier,Markus von Nickisch-Rosenegk

Mikrochimica acta 181:1707-1714 PubMed25253911

2014

Rapid identification of novel antigens of Enteritidis by microarray-based immunoscreening.

Applications

Unspecified application

Species

Unspecified reactive species

Lena Danckert,Sebastian Hoppe,Frank F Bier,Markus von Nickisch-Rosenegk
View all publications

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