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AB244475

Anti-KLF14 antibody

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(2 Publications)

Rabbit Polyclonal KLF14 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KLF14 aa 250 to C-terminus.

View Alternative Names

BTEB5, KLF14, Krueppel-like factor 14, Basic transcription element-binding protein 5, Transcription factor BTEB5, BTE-binding protein 5

5 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human placenta tissue labeling KLF14 with ab244475 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human pancreas tissue labeling KLF14 with ab244475 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human adrenal gland tissue labeling KLF14 with ab244475 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testis tissue labeling KLF14 with ab244475 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF14 antibody (AB244475)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labeling KLF14 with ab244475 at 1/500 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KLF14 aa 250 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q8TD94

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Chimpanzee": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLF14 also known as Krüppel-like factor 14 functions as a transcription factor that influences gene expression by binding to specific DNA sequences. This protein has a mass of approximately 29 kDa. Researchers have observed KLF14 expression in multiple tissues including adipose tissue liver and skeletal muscle. Its role in regulating various cellular processes makes it a significant protein in understanding different biological mechanisms.
Biological function summary

KLF14 serves as a critical regulator of lipid metabolism and insulin sensitivity involved in both separate and complex cellular interactions. KLF14 modulates the expression of genes related to these processes influencing how the body manages lipid storage and glucose homeostasis. It does not form large multimeric complexes but interfaces with other transcription factors to execute its regulatory duties efficiently. Its activity contributes importantly to maintaining energy balance within the body.

Pathways

Researchers have identified KLF14 as an influential part of the adipogenesis and insulin signaling pathways. It interacts with other proteins such as PPARγ and SREBP1 which play notable roles within these pathways. KLF14's modulation of gene expression impacts the pathway outcomes leading to effects on cellular metabolism and systemic energy homeostasis. Its involvement in pathways related to glucose and lipid metabolism illustrates its key role in these physiological processes.

Scientists have associated KLF14 with type 2 diabetes and cardiovascular disease. Changes in KLF14 expression or function can impact insulin resistance and dyslipidemia contributing to the progression of these conditions. It also links to proteins such as TCF7L2 and adiponectin which are related to the metabolic disturbances seen in these diseases. Understanding KLF14's role provides insight into therapeutic targets for managing and potentially treating such metabolic disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

See full target information KLF14
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Publications (2)

Recent publications for all applications. Explore the full list and refine your search

Journal of experimental & clinical cancer research : CR 42:5 PubMed36600258

2023

KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Zhou,Junru Chen,Mingjie Fan,Huajian Cai,Yufei Dong,Yue Qiu,Qianqian Zhuang,Zhaoying Lei,Mengyao Li,Xue Ding,Peng Yan,Aifu Lin,Shusen Zheng,Qingfeng Yan

Frontiers in oncology 12:795971 PubMed35814368

2022

Expression Promotes Lung Adenocarcinoma Progression and Is Associated With Poor Prognosis.

Applications

Unspecified application

Species

Unspecified reactive species

Feng Jiang,Xiaolu Huang,Xiang Yang,Huixin Zhou,Yumin Wang
View all publications
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