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AB167192

Anti-KLF15 antibody

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(5 Publications)

Mouse Polyclonal KLF15 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF15.

View Alternative Names

KKLF, KLF15, Krueppel-like factor 15, Kidney-enriched krueppel-like factor

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-KLF15 antibody (AB167192)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-KLF15 antibody (AB167192)

Immunofluorescent analysis of HepG2 cells labeling KLF15 with ab167192 at 10 ug/ml.

Western blot - Anti-KLF15 antibody (AB167192)
  • WB

Unknown

Western blot - Anti-KLF15 antibody (AB167192)

All lanes:

Western blot - Anti-KLF15 antibody (ab167192) at 1 µg/mL

Lane 1:

Lysate of 293T cells transfected with KLF15 at 15 µL

Lane 2:

Lysate of 293T cells (non-transfected) at 15 µL

Secondary

All lanes:

Goat anti-mouse HRP conjugated antibody at 1/2500 dilution

Predicted band size: 119 kDa,33 kDa,34 kDa,36 kDa,38 kDa,39 kDa,40 kDa,42 kDa,43 kDa,44 kDa,45 kDa,47 kDa,49 kDa,77 kDa

false

Key facts

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Full Length Protein corresponding to Human KLF15.

Q9UIH9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "10 µg/mL", "ICCIF-species-notes": "<p></p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Protein A
Storage buffer
pH: 7.4 Constituents: PBS
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLF15 also known as Kruppel-like factor 15 works mechanically as a transcription factor. The KLF15 protein with a molecular mass of approximately 44 kDa functions by regulating the expression of genes involved in metabolism and cell differentiation. It is expressed in various tissues including the heart liver and skeletal muscle. This expression suggests that the KLF-15 protein plays a significant role in maintaining tissue-specific functions.
Biological function summary

KLF15 influences several cellular processes by regulating gene expression. It is part of a transcription factor complex that modulates glucose metabolism lipid metabolism and muscle differentiation. The KLF-15 protein contributes to maintaining homeostasis by upregulating genes responsible for gluconeogenesis and lipid usage which is essential in adapting to fasting states. Additionally it impacts muscle cell differentiation by influencing the expression of specific myogenic factors.

Pathways

KLF15 is significant in metabolic and myogenic pathways. It upregulates genes involved in the gluconeogenesis pathway and fatty acid oxidation collaborating with proteins such as PGC-1α. Additionally within myogenic pathways KLF-15 protein interacts with myogenic regulatory factors contributing to muscle differentiation. These interactions highlight its importance in metabolic and muscle function pathways and highlight its regulatory capacity across different biological processes.

KLF15 has important roles. Alterations in KLF-15 protein levels link to metabolic diseases such as diabetes and cardiac hypertrophy. In diabetes it affects glucose metabolism and insulin sensitivity with connections to proteins like FOXO1. In cardiac hypertrophy KLF-15 influences structural remodeling of the heart potentially interacting with hypertrophy-associated factors. This connection to diseases emphasizes its potential as a therapeutic target for related disorders.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
See full target information KLF15
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Publications (5)

Recent publications for all applications. Explore the full list and refine your search

Communications biology 6:1059 PubMed37853052

2023

Pseudogene MAPK6P4-encoded functional peptide promotes glioblastoma vasculogenic mimicry development.

Applications

Unspecified application

Species

Unspecified reactive species

Mengyang Zhang,Yubo Zhao,Xiaobai Liu,Xuelei Ruan,Ping Wang,Libo Liu,Di Wang,Weiwei Dong,Chunqing Yang,Yixue Xue

Translational oncology 30:101635 PubMed36774884

2023

Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A.

Applications

Unspecified application

Species

Unspecified reactive species

Zi-Hao Wang,Lin-Lin Ye,Xuan Xiang,Xiao-Shan Wei,Yi-Ran Niu,Wen-Bei Peng,Si-Yu Zhang,Pei Zhang,Qian-Qian Xue,Hao-Lei Wang,Yi-Heng Du,Yao Liu,Jia-Qi Ai,Qiong Zhou

Viruses 13: PubMed34203849

2021

Regulation of Krüppel-Like Factor 15 Expression by Herpes Simplex Virus Type 1 or Bovine Herpesvirus 1 Productive Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Fouad S El-Mayet,Kelly S Harrison,Clinton Jones

Acta histochemica 121:253-259 PubMed30611528

2019

Curcumin represses adipogenic differentiation of human bone marrow mesenchymal stem cells via inhibiting kruppel-like factor 15 expression.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Wang,Ruiqiao Yan,Xiaoyuan Xu,Xingnuan Li,Lingling Cao,Liyun Gao,Jianyun Liu,Xiaoou Zhou,Hui Yu,Xinping Wang,He Jiang,Yaofang Yang

International journal of molecular medicine 42:1593-1602 PubMed29901095

2018

Loss of KLF15 accelerates chronic podocyte injury.

Applications

Unspecified application

Species

Unspecified reactive species

Seung Seok Han,Mi-Yeon Yu,Kyung Don Yoo,Jung Pyo Lee,Dong Ki Kim,Yon Su Kim,Seung Hee Yang
View all publications
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Product promise

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