Mouse Polyclonal KLF15 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF15.
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- Communications biology 6:10592023Pseudogene MAPK6P4-encoded functional peptide promotes glioblastoma vasculogenic mimicry development.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMengyang Zhang,Yubo Zhao,Xiaobai Liu,Xuelei Ruan,Ping Wang,Libo Liu,Di Wang,Weiwei Dong,Chunqing Yang,Yixue XuePubMed 37853052
- Translational oncology 30:1016352023Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A.Applications:Unspecified applicationReactive species:Unspecified reactive speciesZi-Hao Wang,Lin-Lin Ye,Xuan Xiang,Xiao-Shan Wei,Yi-Ran Niu,Wen-Bei Peng,Si-Yu Zhang,Pei Zhang,Qian-Qian Xue,Hao-Lei Wang,Yi-Heng Du,Yao Liu,Jia-Qi Ai,Qiong ZhouPubMed 36774884
- Viruses 13:2021Regulation of Krüppel-Like Factor 15 Expression by Herpes Simplex Virus Type 1 or Bovine Herpesvirus 1 Productive Infection.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFouad S El-Mayet,Kelly S Harrison,Clinton JonesPubMed 34203849
- Acta histochemica 121:253-2592019Curcumin represses adipogenic differentiation of human bone marrow mesenchymal stem cells via inhibiting kruppel-like factor 15 expression.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTao Wang et. al.PubMed 30611528
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human KLF15. Database link Q9UIH9
Reactivity data
Select an application| WB | ICC/IF | |
|---|---|---|
| Human | Tested | Tested |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1 µg/mL | Notes - |
ICC/IF
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 10 µg/mL | Notes - |
Associated Products
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Target data
Function
Transcriptional regulator that binds to the GA element of the CLCNKA promoter. Binds to the KCNIP2 promoter and regulates KCNIP2 circadian expression in the heart (By similarity). Is a repressor of CCN2 expression, involved in the control of cardiac fibrosis. It is also involved in the control of cardiac hypertrophy acting through the inhibition of MEF2A and GATA4 (By similarity). Involved in podocyte differentiation (By similarity). Inhibits MYOCD activity. Is a negative regulator of TP53 acetylation. Inhibits NF-kappa-B activation through repression of EP300-dependent RELA acetylation.
Alternative names
KKLF, KLF15, Krueppel-like factor 15, Kidney-enriched krueppel-like factor
Recommended products
Mouse Polyclonal KLF15 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF15.
Key facts
- Isotype
- IgG
- Host species
- Mouse
- Storage buffer
pH: 7.4
Constituents: 99% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human KLF15. Database link Q9UIH9
- Purification technique
- Affinity purification Protein A
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
KLF15 also known as Kruppel-like factor 15 works mechanically as a transcription factor. The KLF15 protein with a molecular mass of approximately 44 kDa functions by regulating the expression of genes involved in metabolism and cell differentiation. It is expressed in various tissues including the heart liver and skeletal muscle. This expression suggests that the KLF-15 protein plays a significant role in maintaining tissue-specific functions.
- Biological function summary
KLF15 influences several cellular processes by regulating gene expression. It is part of a transcription factor complex that modulates glucose metabolism lipid metabolism and muscle differentiation. The KLF-15 protein contributes to maintaining homeostasis by upregulating genes responsible for gluconeogenesis and lipid usage which is essential in adapting to fasting states. Additionally it impacts muscle cell differentiation by influencing the expression of specific myogenic factors.
- Pathways
KLF15 is significant in metabolic and myogenic pathways. It upregulates genes involved in the gluconeogenesis pathway and fatty acid oxidation collaborating with proteins such as PGC-1α. Additionally within myogenic pathways KLF-15 protein interacts with myogenic regulatory factors contributing to muscle differentiation. These interactions highlight its importance in metabolic and muscle function pathways and highlight its regulatory capacity across different biological processes.
- Associated diseases and disorders
KLF15 has important roles. Alterations in KLF-15 protein levels link to metabolic diseases such as diabetes and cardiac hypertrophy. In diabetes it affects glucose metabolism and insulin sensitivity with connections to proteins like FOXO1. In cardiac hypertrophy KLF-15 influences structural remodeling of the heart potentially interacting with hypertrophy-associated factors. This connection to diseases emphasizes its potential as a therapeutic target for related disorders.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-KLF15 antibody (ab167192)
All lanes: Western blot - Anti-KLF15 antibody (ab167192) at 1 µg/mL
Lane 1: Lysate of 293T cells transfected with KLF15 at 15 µL
Lane 2: Lysate of 293T cells (non-transfected) at 15 µL
SecondaryAll lanes: Goat anti-mouse HRP conjugated antibody at 1/2500 dilution
Predicted band size: 119 kDa, 33 kDa, 34 kDa, 36 kDa, 38 kDa, 39 kDa, 40 kDa, 42 kDa, 43 kDa, 44 kDa, 45 kDa, 47 kDa, 49 kDa, 77 kDa
Immunocytochemistry/ Immunofluorescence - Anti-KLF15 antibody (ab167192)
Immunofluorescent analysis of HepG2 cells labeling KLF15 with ab167192 at 10 ug/ml.
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