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AB241385

Anti-KLF6 antibody

1

(2 Reviews)

|

(8 Publications)

Rabbit Polyclonal KLF6 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 8 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KLF6 aa 150-250.

View Alternative Names

BCD1, COPEB, CPBP, ST12, KLF6, Krueppel-like factor 6, B-cell-derived protein 1, Core promoter element-binding protein, GC-rich sites-binding factor GBF, Proto-oncogene BCD1, Suppressor of tumorigenicity 12 protein, Transcription factor Zf9

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF6 antibody (AB241385)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF6 antibody (AB241385)

Formalin-fixed, paraffin-embedded human gallbladder tissue stained for KLF6 with ab241385 at 1/1000 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-KLF6 antibody (AB241385)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-KLF6 antibody (AB241385)

SK-MEL-30 cells stained for KLF6 using ab241385 at 4 μg/ml (green) in ICC/IF.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human KLF6 aa 150-250. The exact immunogen used to generate this antibody is proprietary information.

Q99612

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500 - 1/1000", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLF6 also known as Kruppel-like factor 6 is a transcription factor involved in regulating gene expression. It has a molecular weight of approximately 31 kDa. KLF6 distributes in various tissues including the liver lungs and kidneys where it influences cellular growth differentiation and apoptosis. Researchers often identify this factor by its notable zinc finger DNA-binding motif which facilitates its role in controlling target genes' transcription.
Biological function summary

KLF6 influences several cellular processes by acting as a transcriptional activator. It forms part of larger transcriptional complexes that modulate gene expression in response to specific cellular contexts. For instance KLF6 contributes to cell growth regulation by affecting genes involved in the cell cycle and apoptosis. Its function as a tumor suppressor has gained considerable interest for its involvement in cellular responses to damage and repair.

Pathways

KLF6 interacts with different cellular signaling routes to maintain homeostasis. It plays a significant role in the TGF-β signaling pathway which is important for maintaining cell stability and promoting apoptosis. Additionally it associates with the p53 pathway enhancing its ability to suppress tumor formation. Through these interactions KLF6 works alongside proteins such as SMAD3 and p53 to ensure proper regulation of cellular growth and repair.

KLF6 has associations with cancer and fibrotic diseases. Many studies link reduced or altered KLF6 expression to various human cancers such as prostate and colorectal cancers due to its tumor suppressor function. KLF6 also relates to cardiovascular diseases through its influence on genes associated with fibrosis and inflammation. In these contexts it interacts with other proteins like SMAD3 and TGF-β highlighting its role in disease progression and severity.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Transcriptional activator (By similarity). Binds a GC box motif. Could play a role in B-cell growth and development.
See full target information KLF6
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Publications (8)

Recent publications for all applications. Explore the full list and refine your search

Nature cancer : PubMed40999053

2025

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence.

Applications

Unspecified application

Species

Unspecified reactive species

Kaloyan M Tsanov,Francisco M Barriga,Yu-Jui Ho,Direna Alonso-Curbelo,Geulah Livshits,Sha Tian,Richard P Koche,Timour Baslan,Janelle Simon,Alexandra N Wuest,José Reyes,Jin Park,Wei Luan,John E Wilkinson,Umesh Bhanot,Jordana Ray-Kirton,Ignas Masilionis,Nevenka Dimitrova,Christine A Iacobuzio-Donahue,Ronan Chaligné,Dana Pe'er,Joan Massagué,Scott W Lowe

Journal of personalized medicine 14: PubMed38673008

2024

Alteration of the Expression and Functional Activities of Myosin II Isoforms in Enlarged Hyperplastic Prostates.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao Wang,Weixiang He,Hui Chen,Rui Yang,Hongmei Su,Michael E DiSanto,Xinhua Zhang

Journal of Cancer 14:163-173 PubMed36605481

2023

Hypoxia-induced miR-653 enhances colorectal cancer progression by targeting circSETD3/KLF6 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Qian Chen,Qingchun Deng,Yinglian Pan,Xiangwu Ding,Jing Liu

Cancer medicine 12:4968-4980 PubMed36056909

2022

Risk stratification and prognosis prediction based on inflammation-related gene signature in lung squamous carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenyu Zhai,Si Chen,Fangfang Duan,Junye Wang,Zerui Zhao,Yaobin Lin,Bingyu Rao,Yizhi Wang,Lie Zheng,Hao Long

Nature communications 13:4918 PubMed35995799

2022

Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Xue Xie,Nima N Naseri,Jasmine Fels,Parinati Kharel,Yoonmi Na,Diane Lane,Jacqueline Burré,Manu Sharma

Computational and mathematical methods in medicine 2022:3193553 PubMed35136416

2022

Krüppel-Like Factor 6 Downregulation Is Connected with a Poor Prognosis and Tumor Growth in Non-Small-Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Binbin Zeng,Jiaxin Lin,Xingdong Cai,Li Che,Wei Zeng,Shengming Liu

Genes & genomics 43:1307-1316 PubMed34524611

2021

MiR-200c-3p aggravates gastric cell carcinoma via KLF6.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Wang,Kaijuan Lu,Weibing Li,Zhigang Wang,Jing Ding,Zeyu Zhu,Zhipeng Li

Cancer management and research 12:5931-5943 PubMed32765094

2020

Paeonol Inhibits Cell Proliferation, Migration and Invasion and Induces Apoptosis in Hepatocellular Carcinoma by Regulating miR-21-5p/KLF6 Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Miaoguo Cai,Wei Shao,Huijun Yu,Ye Hong,Lili Shi
View all publications
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Product promise

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