AB197690

Anti-KLF7 antibody

Name: Anti-KLF7 antibody (ab197690) | Abcam
Brand: Abcam Limited
SKU: AB197690
Price: 525 USD
Availability: InStock

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(21 Publications)

Rabbit Polyclonal KLF7 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 21 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF7.

View Alternative Names

UKLF, KLF7, Krueppel-like factor 7, Ubiquitous krueppel-like factor

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF7 antibody (AB197690)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF7 antibody (AB197690)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling KLF7 with ab197690 at 1/60 dilution.

Supplier Data

Western blot - Anti-KLF7 antibody (AB197690)

8% SDS-PAGE

All lanes:

Western blot - Anti-KLF7 antibody (ab197690) at 1/483 dilution

Lane 1:

Human colon cancer tissue lysate at 40 µg

Lane 2:

Mouse kidney tissue lysate at 40 µg

Lane 3:

Mouse testis tissue lysate at 40 µg

Lane 4:

Human fetal brain tissue lysate at 40 µg

Predicted band size: 33 kDa

false

Exposure time: 20s

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human KLF7.

O75840

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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Properties and storage information

Form

Liquid

Purification technique

Affinity purification Immunogen

Storage buffer

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

Shipped at conditions

Blue Ice

Appropriate short-term storage duration

1-2 weeks

Appropriate short-term storage conditions

+4°C

Appropriate long-term storage conditions

-20°C

Aliquoting information

Upon delivery aliquot

Storage information

Avoid freeze / thaw cycle

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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLF7 also known as Kruppel-like factor 7 is a transcription factor that plays an important role in cellular regulation. It carries a mass of approximately 45 kDa and is expressed in a variety of tissue types most notably in neural tissues. KLF7 is one of the KLF family proteins characterized by the presence of three C2H2 zinc fingers that facilitate DNA binding. It primarily regulates gene expression by binding to GC-rich regions of DNA influencing the transcription of specific target genes.

Biological function summary

KLF7 facilitates neuronal and adipocyte differentiation and development. Its involvement in these processes highlights its role in critical developmental phases. Although there is limited information about its involvement in multi-protein complexes its function as a transcription factor suggests that it likely interacts with other proteins involved in gene regulation. By modulating gene expression patterns KLF7 contributes to the establishment of cell identity and functionality.

Pathways

KLF7 is heavily engaged in the pathways of neural development and adipogenesis. It is intricately linked with the Notch signaling pathway where it influences the expression of genes involved in cell differentiation. Furthermore KLF7 interacts with other transcription factors such as KLF4 and KLF5 within these pathways collectively shaping cell fate decisions and development outcomes. This interconnectedness highlights KLF7's comprehensive influence over significant physiological processes.

KLF7 has been implicated in neurodegenerative diseases and obesity. In Alzheimer's disease for instance KLF7 expression changes are observed suggesting its potential role in disease progression. This link to Alzheimer's positions KLF7 alongside proteins like APP which are also affected in such conditions. Additionally in obesity alterations in KLF7 expression can affect adipogenesis making it closely associated with metabolic regulation and related disorders. The protein's involvement in these conditions makes it a potential target for therapeutic intervention.

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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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Target data

Transcriptional factor (PubMed : 16339272, PubMed : 9774444). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed : 28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed : 16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed : 16339272).

See full target information KLF7

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Publications (21)

Recent publications for all applications. Explore the full list and refine your search

Cell death & disease 16:354 PubMed40316546

2025

KLF7-regulated ITGA2 as a therapeutic target for inhibiting oral cancer stem cells.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Qi,Jiang Zhou,Pan Wang,Yunyan Li,Haoran Li,Yuwen Miao,XiaoQing Ma,Xiayan Luo,Zhiling Zhang,Yanling He,Wenyi Shen,Wenquan Zhao,Rutao Cui,Cang Li,Huiyong Zhu,Jiong Lyu

Acta biochimica et biophysica Sinica 57:1636-1646 PubMed40055913

2025

circ_0000389 inhibits intervertebral disc degeneration by targeting the miR-346/KLF7 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Chun Liu,Cheng Yu,Yang Duan,Jianjun Li,Xiang Chen,Wenning Xu,Sujun Qiu

Journal of cellular and molecular medicine 28:e70245 PubMed39648156

2024

KLF7 Promotes Hepatocellular Carcinoma Progression Through Regulating SLC1A5-Mediated Tryptophan Metabolism.

Applications

Unspecified application

Species

Unspecified reactive species

Bao Chai,Anhong Zhang,Yang Liu,Xi Zhang,Pengzhou Kong,Zhuowei Zhang,Yarong Guo

BMC cancer 23:426 PubMed37170248

2023

Caprylic Acid (FFA C8:0) promotes the progression of prostate cancer by up-regulating G protein-coupled receptor 84/ Krüppel-like factor 7.

Applications

Unspecified application

Species

Unspecified reactive species

Xue Li,Chenggang Yuan,Bingqi Yang,Huai Pang,Wei Li,Menghuan Li,Yihan Tang,Dingling Ma,Jianxin Xie,Jingzhou Wang,Jun Zhang

Heliyon 9:e14931 PubMed37025783

2023

Stress-inducible IL-6 is regulated by KLF7 in brown adipocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Yihan Tang,Dingling Ma,Maodi Liang,Yanting Hou,Meixiu Zhang,Jingzhou Wang,Chenggang Yuan,Menghuan Li,Chaoyue Sun,Jianxin Xie,Cuizhe Wang,Jun Zhang

Diabetology & metabolic syndrome 15:11 PubMed36698180

2023

miR-132-3p and KLF7 as novel regulators of aortic stiffening-associated EndMT in type 2 diabetes mellitus.

Applications

Unspecified application

Species

Unspecified reactive species

Melanie S Hulshoff,Isabel N Schellinger,Xingbo Xu,Jolien Fledderus,Sandip K Rath,Fang Cheng Wong,Sabine Maamari,Josephina Haunschild,Guido Krenning,Uwe Raaz,Elisabeth M Zeisberg

Breast cancer research : BCR 24:65 PubMed36192788

2022

Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Anne-Marie Lüchtenborg,Patrick Metzger,Miguel Cosenza Contreras,Victor Oria,Martin L Biniossek,Franziska Lindner,Klemens Fröhlich,Ambrus Malyi,Thalia Erbes,Nicole Gensch,Jochen Maurer,Andreas Thomsen,Melanie Boerries,Oliver Schilling,Martin Werner,Peter Bronsert

Cellular and molecular biology (Noisy-le-Grand, France) 68:188-193 PubMed36495497

2022

Long non-coding RNA XIST negatively regulates thoracic aortic aneurysm cell proliferation by targeting the miR-193a-5p/KLF7 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Ming Zhu,Mengwei Tan,Fazhen Xu,Yuting Huang,Jiantian Yang

Cell cycle (Georgetown, Tex.) 21:1590-1598 PubMed35451342

2022

Long noncoding RNA PVT1 regulates the proliferation and apoptosis of ARPE-19 cells via the miR-1301-3p/KLF7 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Jianjin Guo,Yuan Chen,Jiajia Xu,Liqi Li,Wenjiao Dang,Feng Xiao,Wei Ren,Yikun Zhu,Qiujing Du,Qian Li,Xing Li

Nutrition & diabetes 12:23 PubMed35443706

2022

Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Tongtong Qiu,Xin Yang,Jingzhou Wang,Chongge Pan,Xiaolong Chu,Jianyu Xiong,Jianxin Xie,Yongsheng Chang,Cuizhe Wang,Jun Zhang

View all publications

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Product promise

We are committed to supporting your work with high-quality reagents, and we're here for you every step of the way. In the unlikely event that one of our products does not perform as expected, you're protected by our Product Promise.

For full details, please see our Terms & Conditions

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-KLF7 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF7 antibody (AB197690)

Western blot - Anti-KLF7 antibody (AB197690)

Key facts

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

Reactivity data

Properties and storage information

Form

Purification technique

Storage buffer

Shipped at conditions

Appropriate short-term storage duration

Appropriate short-term storage conditions

Appropriate long-term storage conditions

Aliquoting information

Storage information

Supplementary information

Biological function summary

Pathways

Product protocols

Target data

Publications (21)

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