Rabbit Polyclonal KLF7 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 17 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF7.
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- BMC cancer 23:4262023Caprylic Acid (FFA C8:0) promotes the progression of prostate cancer by up-regulating G protein-coupled receptor 84/ Krüppel-like factor 7.Applications:Unspecified applicationReactive species:Unspecified reactive speciesXue Li,Chenggang Yuan,Bingqi Yang,Huai Pang,Wei Li,Menghuan Li,Yihan Tang,Dingling Ma,Jianxin Xie,Jingzhou Wang,Jun ZhangPubMed 37170248
- Heliyon 9:e149312023Stress-inducible IL-6 is regulated by KLF7 in brown adipocytes.Applications:Unspecified applicationReactive species:Unspecified reactive speciesYihan Tang,Dingling Ma,Maodi Liang,Yanting Hou,Meixiu Zhang,Jingzhou Wang,Chenggang Yuan,Menghuan Li,Chaoyue Sun,Jianxin Xie,Cuizhe Wang,Jun ZhangPubMed 37025783
- Diabetology & metabolic syndrome 15:112023miR-132-3p and KLF7 as novel regulators of aortic stiffening-associated EndMT in type 2 diabetes mellitus.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMelanie S Hulshoff,Isabel N Schellinger,Xingbo Xu,Jolien Fledderus,Sandip K Rath,Fang Cheng Wong,Sabine Maamari,Josephina Haunschild,Guido Krenning,Uwe Raaz,Elisabeth M ZeisbergPubMed 36698180
- Breast cancer research : BCR 24:652022Krüppel-like factor 7 influences translation and pathways involved in ribosomal biogenesis in breast cancer.Applications:Unspecified applicationReactive species:Unspecified reactive speciesAnne-Marie Lüchtenborg,Patrick Metzger,Miguel Cosenza Contreras,Victor Oria,Martin L Biniossek,Franziska Lindner,Klemens Fröhlich,Ambrus Malyi,Thalia Erbes,Nicole Gensch,Jochen Maurer,Andreas Thomsen,Melanie Boerries,Oliver Schilling,Martin Werner,Peter BronsertPubMed 36192788
- Cellular and molecular biology (Noisy-le-Grand, France) 68:188-1932022Long non-coding RNA XIST negatively regulates thoracic aortic aneurysm cell proliferation by targeting the miR-193a-5p/KLF7 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesMing Zhu,Mengwei Tan,Fazhen Xu,Yuting Huang,Jiantian YangPubMed 36495497
- Cell cycle (Georgetown, Tex.) 21:1590-15982022Long noncoding RNA PVT1 regulates the proliferation and apoptosis of ARPE-19 cells via the miR-1301-3p/KLF7 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJianjin Guo,Yuan Chen,Jiajia Xu,Liqi Li,Wenjiao Dang,Feng Xiao,Wei Ren,Yikun Zhu,Qiujing Du,Qian Li,Xing LiPubMed 35451342
- Nutrition & diabetes 12:232022Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway.Applications:Unspecified applicationReactive species:Unspecified reactive speciesTongtong Qiu,Xin Yang,Jingzhou Wang,Chongge Pan,Xiaolong Chu,Jianyu Xiong,Jianxin Xie,Yongsheng Chang,Cuizhe Wang,Jun ZhangPubMed 35443706
- Gerontology 68:1291-13102022KLF7 Alleviates Atherosclerotic Lesions and Inhibits Glucose Metabolic Reprogramming in Macrophages by Regulating HDAC4/miR-148b-3p/NCOR1.Applications:Unspecified applicationReactive species:Unspecified reactive speciesFangyuan Chen,Juanli Li,Tao Zheng,Tao Chen,Zuyi YuanPubMed 35439761
- Journal of Cancer 12:6330-63432021Role of long intergenic non-protein coding RNA 00152 in pancreatic cancer glycolysis the manipulation of the microRNA-185-5p/Krüppel-like factor 7 axis.Applications:Unspecified applicationReactive species:Unspecified reactive speciesHaifeng Li,Hao Shen,Peng Xie,Zheng Zhang,Lishan Wang,Yang Yang,Zeqian Yu,Zhangjun Cheng,Jiahua ZhouPubMed 34659523
- BMC cancer 21:4562021GNA14 stimulation of KLF7 promotes malignant growth of endometrial cancer through upregulation of HAS2.Applications:Unspecified applicationReactive species:Unspecified reactive speciesJing Wang,Fei Teng,Hongxia Chai,Caixia Zhang,Xiaolei Liang,Yongxiu YangPubMed 33892667
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
Immunogen
- Recombinant Full Length Protein corresponding to Human KLF7. Database link O75840
Reactivity data
Select an application| WB | IHC-P | |
|---|---|---|
| Human | Tested | Tested |
| Mouse | Tested | Expected |
| Rat | Predicted | Predicted |
WB
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info 1/500.00000 - 1/2000.00000 | Notes - |
Species Human | Dilution info 1/500.00000 - 1/2000.00000 | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
IHC-P
TestedTested
| Species | Dilution info | Notes |
|---|---|---|
Species Human | Dilution info 1/50.00000 - 1/200.00000 | Notes - |
ExpectedExpected
| Species | Dilution info | Notes |
|---|---|---|
Species Mouse | Dilution info Use at an assay dependent concentration. | Notes - |
PredictedPredicted
| Species | Dilution info | Notes |
|---|---|---|
Species Rat | Dilution info - | Notes - |
Target data
Function
Transcriptional factor (PubMed:16339272, PubMed:9774444). Plays a critical role in neuronal morphogenesis and survival of sensory neurons (By similarity). Represses the corneal epithelium differentiation (PubMed:28916725). Acts also as a metabolic regulator, by modulating insulin sensitivity in pancreatic beta cells and skeletal muscle cells (PubMed:16339272). Inhibits transcriptional inducers of adipogenesis and has a repressive role in the expression of several adipokines, including leptin (PubMed:16339272).
Alternative names
UKLF, KLF7, Krueppel-like factor 7, Ubiquitous krueppel-like factor
Recommended products
Rabbit Polyclonal KLF7 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 17 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human KLF7.
Key facts
- Isotype
- IgG
- Host species
- Rabbit
- Storage buffer
pH: 7.4
Preservative: 0.05% Sodium azide
Constituents: 50% Glycerol (glycerin, glycerine), 49% PBS- Form
- Liquid
- Clonality
- Polyclonal
- Immunogen
- Recombinant Full Length Protein corresponding to Human KLF7. Database link O75840
- Purification technique
- Affinity purification Immunogen
- Concentration
Storage
- Shipped at conditions
- Blue Ice
- Appropriate short-term storage duration
- 1-2 weeks
- Appropriate short-term storage conditions
- +4°C
- Appropriate long-term storage conditions
- -20°C
- Aliquoting information
- Upon delivery aliquot
- Storage information
- Avoid freeze / thaw cycle
Notes
Abcam is leading the way to address reproducibility in scientific research with our highly validated recombinant monoclonal and recombinant multiclonal antibodies. Search & select one of Abcam's thousands of recombinant alternatives to eliminate batch-variability and unnecessary animal use.
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Abcam antibodies are extensively validated in a wide range of species and applications, so please check the reagent specifications meet your scientific needs before purchasing. If you have any questions or bespoke requirements, simply visit the Contact Us page to send us an inquiry or contact our Support Team ahead of purchase.
Supplementary info
- This supplementary information is collated from multiple sources and compiled automatically.
- Activity summary
KLF7 also known as Kruppel-like factor 7 is a transcription factor that plays an important role in cellular regulation. It carries a mass of approximately 45 kDa and is expressed in a variety of tissue types most notably in neural tissues. KLF7 is one of the KLF family proteins characterized by the presence of three C2H2 zinc fingers that facilitate DNA binding. It primarily regulates gene expression by binding to GC-rich regions of DNA influencing the transcription of specific target genes.
- Biological function summary
KLF7 facilitates neuronal and adipocyte differentiation and development. Its involvement in these processes highlights its role in critical developmental phases. Although there is limited information about its involvement in multi-protein complexes its function as a transcription factor suggests that it likely interacts with other proteins involved in gene regulation. By modulating gene expression patterns KLF7 contributes to the establishment of cell identity and functionality.
- Pathways
KLF7 is heavily engaged in the pathways of neural development and adipogenesis. It is intricately linked with the Notch signaling pathway where it influences the expression of genes involved in cell differentiation. Furthermore KLF7 interacts with other transcription factors such as KLF4 and KLF5 within these pathways collectively shaping cell fate decisions and development outcomes. This interconnectedness highlights KLF7's comprehensive influence over significant physiological processes.
- Associated diseases and disorders
KLF7 has been implicated in neurodegenerative diseases and obesity. In Alzheimer's disease for instance KLF7 expression changes are observed suggesting its potential role in disease progression. This link to Alzheimer's positions KLF7 alongside proteins like APP which are also affected in such conditions. Additionally in obesity alterations in KLF7 expression can affect adipogenesis making it closely associated with metabolic regulation and related disorders. The protein's involvement in these conditions makes it a potential target for therapeutic intervention.
Product promise
Tested
We have tested this species and application combination and it works. It is covered by our product promise.
Expected
We have not tested this specific species and application combination in-house, but expect it will work. It is covered by our product promise.
Predicted
This species and application combination has not been tested, but we predict it will work based on strong homology. However, this combination is not covered by our product promise.
Not recommended
We do not recommend this combination. It is not covered by our product promise.
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2 product images
Western blot - Anti-KLF7 antibody (ab197690)
8% SDS-PAGE
All lanes: Western blot - Anti-KLF7 antibody (ab197690) at 1/483 dilution
Lane 1: Human colon cancer tissue lysate at 40 µg
Lane 2: Mouse kidney tissue lysate at 40 µg
Lane 3: Mouse testis tissue lysate at 40 µg
Lane 4: Human fetal brain tissue lysate at 40 µg
Predicted band size: 33 kDa
Exposure time: 20s
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLF7 antibody (ab197690)
Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling KLF7 with ab197690 at 1/60 dilution.
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