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AB272605

Anti-KLHDC3 antibody

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(1 Publication)

Rabbit Polyclonal KLHDC3 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KLHDC3 aa 300 to C-terminus.

View Alternative Names

PEAS, KLHDC3, Kelch domain-containing protein 3, Testis intracellular mediator protein

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-KLHDC3 antibody (AB272605)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-KLHDC3 antibody (AB272605)

PFA fixed, Triton X-100 permeablized human cell line U-251 MG labeling KLHDC3 (green) using ab272605 at 2 ug/ml in ICC/IF analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLHDC3 antibody (AB272605)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-KLHDC3 antibody (AB272605)

Paraffin-embedded formalin-fixed Human cerebral tissue stained for KLHDC3 using ab272605 at 1/500 in immunohistochemical analysis.

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human KLHDC3 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9BQ90

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLHDC3 also known as Kelch Domain Containing 3 is a protein with a mass of approximately 30 kDa. It is characterized by the presence of a Kelch domain which enables protein-protein interactions. It is expressed in various tissues with notable presence in the brain and testes. This protein is part of the Kelch domain-containing family which often plays roles in scaffolding and organizing protein complexes within cells.
Biological function summary

KLHDC3 participates in cellular processes such as transcriptional regulation and cell cycle control. It is involved in forming protein complexes that modify transcriptional responses. These complexes interact with a variety of transcription factors impacting gene expression. KLHDC3 also regulates the stability and degradation of certain proteins by acting as an adapter for ubiquitination processes.

Pathways

KLHDC3 plays a role in critical pathways like the ubiquitin-proteasome system and the Wnt signaling pathway. It interacts with proteins involved in these pathways such as Beta-catenin influencing cellular growth and development. The ubiquitin-proteasome system is essential for protein turnover while Wnt signaling regulates gene transcription that affects embryogenesis and cell proliferation.

KLHDC3 has been linked to disorders like neurodegenerative diseases and certain cancers. Aberrant functioning of KLHDC3 or its related pathways can disrupt normal cellular processes leading to disease development. For example its interaction with Beta-catenin can influence pathways associated with tumor progression. Further research aims to understand how KLHDC3 modulations contribute to disease pathology and may guide therapeutic approaches.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Substrate-recognition component of a Cul2-RING (CRL2) E3 ubiquitin-protein ligase complex of the DesCEND (destruction via C-end degrons) pathway, which recognizes a C-degron located at the extreme C terminus of target proteins, leading to their ubiquitination and degradation (PubMed : 29775578, PubMed : 29779948). The C-degron recognized by the DesCEND pathway is usually a motif of less than ten residues and can be present in full-length proteins, truncated proteins or proteolytically cleaved forms (PubMed : 29775578, PubMed : 29779948). The CRL2(KLHDC3) complex specifically recognizes proteins with a glycine (Gly) at the C-terminus, leading to their ubiquitination and degradation : recognizes the C-terminal -Arg-(Xaa)n-Arg-Gly, -Arg-(Xaa)n-Lys-Gly, and -Arg-(Xaa)n-Gln-Gly degrons (PubMed : 29775578, PubMed : 29779948). The CRL2(KLHDC3) complex mediates ubiquitination and degradation of truncated SELENOV and SEPHS2 selenoproteins produced by failed UGA/Sec decoding, which end with a glycine (PubMed : 26138980). May be involved in meiotic recombination process (PubMed : 12606021).
See full target information KLHDC3
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Journal of Cancer 15:6434-6451 PubMed39513122

2024

: Expression Patterns, Clinical Correlates and New Target of Papillary Thyroid Carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Dechao Yin,Kun Wang,Junyu Zhao,Jinming Yao,Xiaofang Han,Bo Yan,Jianjun Dong,Lin Liao
View all publications
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Product promise

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