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AB229150

Anti-KLHL13 antibody - N-terminal

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(1 Publication)

Rabbit Polyclonal KLHL13 antibody. N-terminal. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human KLHL13.

View Alternative Names

BKLHD2, KIAA1309, KLHL13, Kelch-like protein 13, BTB and kelch domain-containing protein 2

1 Images
Western blot - Anti-KLHL13 antibody - N-terminal (AB229150)
  • WB

Supplier Data

Western blot - Anti-KLHL13 antibody - N-terminal (AB229150)

7.5% SDS-PAGE gel.

All lanes:

Western blot - Anti-KLHL13 antibody - N-terminal (ab229150) at 1/1000 dilution

All lanes:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate at 30 µg

Predicted band size: 74 kDa,78 kDa

true

Key facts

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Human KLHL13. The exact immunogen used to generate this antibody is proprietary information.

Q9P2N7

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }
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Properties and storage information

Form
Liquid
Purification technique
Affinity purification Immunogen
Storage buffer
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine
Shipped at conditions
Blue Ice
Appropriate short-term storage duration
1-2 weeks
Appropriate short-term storage conditions
+4°C
Appropriate long-term storage conditions
-20°C
Aliquoting information
Upon delivery aliquot
Storage information
Avoid freeze / thaw cycle
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Supplementary information

This supplementary information is collated from multiple sources and compiled automatically.

KLHL13 also known as Kelch-like protein 13 participates in several mechanical processes within the cell. It has a mass of approximately 68 kDa. The protein operates as a member of the Kelch-like (KLHL) family which typically functions in ubiquitin-proteasome pathways. KLHL13 is widely expressed in numerous tissues including the brain heart and skeletal muscle indicating its role in diverse physiological functions.
Biological function summary

KLHL13 interacts with other proteins to form complexes that regulate cellular processes. It often acts as a substrate adaptor in the Cullin-RING E3 ubiquitin ligase complex. This complex targets specific proteins for degradation maintaining protein homeostasis within the cell. KLHL13 thereby influences various cellular occurrences such as signal transduction and cell cycle control by dictating protein turnover rates.

Pathways

KLHL13 impacts several critical biological pathways involved in cellular maintenance and signaling. Its activity is closely tied to the ubiquitin-proteasome pathway where it ensures the degradation of proteins that could alter cell function if accumulated. KLHL13 also shares functional relationships with other Kelch-like family members emphasizing its role in a network where different family proteins can have overlapping and distinct targets.

KLHL13's association with ubiquitin-proteasome pathways links it to neurological disorders such as Parkinson's disease. Abnormal protein degradation in these contexts can lead to protein aggregation and cellular dysfunction. It also relates to certain cancers where dysregulation of protein degradation pathways contributes to uncontrolled cell growth. In these cases KLHL13 interacts with proteins like p53 whose stability and degradation play significant roles in tumor suppression and progression.
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Product protocols

For this product, it's our understanding that no specific protocols are required. You can visit:
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Target data

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for mitotic progression and cytokinesis. The BCR(KLHL9-KLHL13) E3 ubiquitin ligase complex mediates the ubiquitination of AURKB and controls the dynamic behavior of AURKB on mitotic chromosomes and thereby coordinates faithful mitotic progression and completion of cytokinesis.
See full target information KLHL13
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Publications (1)

Recent publications for all applications. Explore the full list and refine your search

Oncology letters 18:4421-4428 PubMed31611951

2019

STAMBPL1 knockdown has antitumour effects on gastric cancer biological activities.

Applications

Unspecified application

Species

Unspecified reactive species

Da-Jun Yu,Jun Qian,Xin Jin,Jing Li,Chen-Xu Guo,Xi-Cheng Yue
View all publications
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