Anti-KLHL13 antibody - N-terminal

Supplementary info

This supplementary information is collated from multiple sources and compiled automatically.

Activity summary

KLHL13 also known as Kelch-like protein 13 participates in several mechanical processes within the cell. It has a mass of approximately 68 kDa. The protein operates as a member of the Kelch-like (KLHL) family which typically functions in ubiquitin-proteasome pathways. KLHL13 is widely expressed in numerous tissues including the brain heart and skeletal muscle indicating its role in diverse physiological functions.

Biological function summary

KLHL13 interacts with other proteins to form complexes that regulate cellular processes. It often acts as a substrate adaptor in the Cullin-RING E3 ubiquitin ligase complex. This complex targets specific proteins for degradation maintaining protein homeostasis within the cell. KLHL13 thereby influences various cellular occurrences such as signal transduction and cell cycle control by dictating protein turnover rates.

Pathways

KLHL13 impacts several critical biological pathways involved in cellular maintenance and signaling. Its activity is closely tied to the ubiquitin-proteasome pathway where it ensures the degradation of proteins that could alter cell function if accumulated. KLHL13 also shares functional relationships with other Kelch-like family members emphasizing its role in a network where different family proteins can have overlapping and distinct targets.

Associated diseases and disorders

KLHL13's association with ubiquitin-proteasome pathways links it to neurological disorders such as Parkinson's disease. Abnormal protein degradation in these contexts can lead to protein aggregation and cellular dysfunction. It also relates to certain cancers where dysregulation of protein degradation pathways contributes to uncontrolled cell growth. In these cases KLHL13 interacts with proteins like p53 whose stability and degradation play significant roles in tumor suppression and progression.